Céline Bourgier
Ghent University
CancerInternal medicineRadiologySurgeryPathologyOncologyMedical physicsRadiation treatment planningChemotherapyMastectomyWhole Breast IrradiationPartial Breast IrradiationGynecologyToxicityNuclear medicineRadiation therapyBreast cancerClinical trialMedicineGastroenterology
Publications 229
#1Céline Bourgier (French Institute of Health and Medical Research)H-Index: 27
#2Didier Cowen (AMU: Aix-Marseille University)H-Index: 1
Last. A. BenyoucefH-Index: 2
view all 29 authors...
PURPOSE To describe the quality assurance (QA) program and early toxicities in the phase III randomized trial BONBIS (NCT00907868) on the role of a localized radiation boost in ductal carcinoma in situ (DCIS). MATERIALS AND METHODS From November 2008 to July 2014, 2004 patients were randomized in arm A (only whole breast radiotherapy, WBRT) and arm B (WBRT + boost). The QA program involved 44 participant centers that performed the dummy run (DR). Compliance and uniformity of clinical target volu...
#1Cécile Charles (University of Bordeaux)
#2Ines Maria Vaz Duarte Luis (Université Paris-Saclay)H-Index: 5
Last. Linda Cambon (University of Bordeaux)H-Index: 10
view all 16 authors...
Resume Introduction Malgre sa frequence et sa penibilite, la fatigue reste insuffisamment prise en charge en oncologie. En l’absence de traitement medicamenteux efficace, les interventions non pharmacologiques occupent une place therapeutique essentielle. Elles sont toutefois mal connues des professionnels qui manquent de reperes pour orienter en confiance les patients. L’article vise a un meilleur reperage dans ce domaine a travers une synthese actualisee des niveaux de recommandations et de pr...
#1Nicola Rares Franco (Ghent University Hospital)H-Index: 1
#2Michela Carlotta Massi (Ghent University Hospital)H-Index: 2
Last. Tiziana RancatiH-Index: 27
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AIM To identify the effect of single nucleotide polymorphism (SNP) interactions on the risk of toxicity following radiotherapy (RT) for prostate cancer (PCa) and propose a new method for polygenic risk score incorporating SNP-SNP interactions (PRSi). MATERIALS AND METHODS Analysis included the REQUITE PCa cohort that received external beam RT and was followed for 2 years. Late toxicity endpoints were: rectal bleeding, urinary frequency, haematuria, nocturia, decreased urinary stream. Among 43 li...
#1Caroline Bascoul-Mollevi (University of Montpellier)H-Index: 24
#2Antoine Barbieri (French Institute of Health and Medical Research)H-Index: 3
Last. Amélie Anota (French Institute of Health and Medical Research)H-Index: 11
view all 13 authors...
Health-related quality of life (HRQoL) is assessed by self-administered questionnaires throughout the care process. Classically, two longitudinal statistical approaches were mainly used to study HRQoL: linear mixed models (LMM) or time-to-event models for time to deterioration/time until definitive deterioration (TTD/TUDD). Recently, an alternative strategy based on generalized linear mixed models for categorical data has also been proposed: the longitudinal partial credit model (LPCM). The obje...
#1Tim Rattay (University of Leicester)H-Index: 9
#2Petra Seibold (DKFZ: German Cancer Research Center)H-Index: 27
Last. Sheryl GreenH-Index: 18
view all 119 authors...
Background: Acute skin toxicity is a common and usually transient side-effect of breast radiotherapy although, if sufficiently severe, it can affect breast cosmesis, aftercare costs and the patient's quality-of-life. The aim of this study was to develop predictive models for acute skin toxicity using published risk factors and externally validate the models in patients recruited into the prospective multi-center REQUITE (validating pREdictive models and biomarkers of radiotherapy toxicity to red...
Last. Antonin Levy (Université Paris-Saclay)H-Index: 25
view all 10 authors...
Advances in physical, technological and biological fields have made radiation oncology a discipline in continual evolution. New current research areas could be implemented in the clinic in the near future. In this review in the form of several interviews, various promising themes for our specialty are described such as the gut microbiota, tumor organoids (or avatar), artificial intelligence, connected therapies, nanotechnologies and plasma laser. The individual prediction of the best therapeutic...
#1Y.M. Kirova (Curie Institute)H-Index: 10
#2Agnès TalletH-Index: 14
Last. Céline Bourgier (University of Montpellier)H-Index: 27
view all 6 authors...
Abstract Cancer and cardiovascular disease (CVD) are the leading cause of mortality worldwide, and breast cancer (BC) the most common malignancy affecting women worldwide. Radiotherapy is an important component of BC treatment and participates in CVD occurrence. It seems, therefore, crucial to gather both radiation oncology and cardiology medical fields to improve the follow-up quality of our BC patients. This review aims at updating our knowledge regarding cardiotoxicities risk factors, and con...
#2Céline Bourgier (University of Montpellier)H-Index: 27
view all 7 authors...
Synchronous metastatic breast cancer accounts for 5 to 6% of all breast cancers in Western countries, which corresponds to nearly 2500 new cases per year in France. Irradiation of the primary tumour in cases of metastatic disease at diagnosis was historically reserved for palliative indications. However, progress in systemic treatments, a better understanding of the biological basis of metastatic dissemination, the genesis of the concept of oligometastatic disease and ablative treatments directe...
#1William Jacot (University of Montpellier)H-Index: 29
#2Martine Mazel (University of Montpellier)H-Index: 9
Last. Catherine Alix-Panabières (University of Montpellier)H-Index: 43
view all 15 authors...
BACKGROUND Data regarding the prognostic value of programmed cell death ligand 1 (PD-L1) expression on circulating tumor cells (CTCs) are lacking. However, CTCs could represent an alternative approach to serial biopsies, allowing real-time monitoring of cancer phenotype. METHODS We evaluated, in a dedicated prospective clinical trial, the clinicopathological correlations and prognostic value of PD-L1(+)-CTCs in 72 patients with metastatic breast cancer (MBC). RESULTS Eighteen of 56 patients with...
#1Meritxell ArenasH-Index: 20
#2Ugur Selek (Koç University)H-Index: 23
Last. Cynthia Aristei (University of Perugia)H-Index: 24
view all 25 authors...
Abstract We report on the second Assisi Think Tank Meeting (ATTM) on breast cancer which was held under the auspices of the European Society for RadioTherapy & Oncology (ESTRO). In discussing in-depth current evidence and practice it was designed to identify grey areas in diverse forms of the disease. It aimed at addressing uncertainties and proposing future trials to improve patient care. Before the meeting, three key topics were selected: 1) primary systemic therapy, mastectomy, breast reconst...
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