Wei Liang
University of California, San Diego
Endothelial stem cellInnate immune systemPathologyCytotoxic T cellStromal cellChemistryApoptosisImmunologyTumor microenvironmentInflammationNeovascularizationSTAT3MetastasisMyeloidLymphBladder cancerAngiogenesisCancer researchCell growthMedicineBiologyImmune systemCell biologyCancer cell
19Publications
10H-index
673Citations
Publications 19
Newest
#1Wei LiangH-Index: 10
#2Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
Cells of the innate immune system are a major component of the tumor microenvironment. They play complex and multifaceted roles in the regulation of cancer initiation, growth, metastasis and responses to therapeutics. Innate immune cells like neutrophils and macrophages are recruited to cancerous tissues by chemotactic molecules released by cancer cells and cancer-associated stromal cells. Once they reach the tumor, they can be instructed by a network of proteins, nucleic acids and metabolites t...
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#1Zhong Cuiling (UCSD: University of California, San Diego)H-Index: 2
#2Pin Li (UCSD: University of California, San Diego)H-Index: 1
Last. Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
view all 10 authors...
Endothelial cell (EC) metabolism is thought to be one of the driving forces for angiogenesis. Here we report the identification of the hexosamine D-mannosamine (ManN) as an EC mitogen and survival factor for bovine and human microvascular EC, with an additivity with VEGF. ManN inhibits glycosylation in ECs and induces significant changes in N-glycan and O-glycan profiles. We further demonstrate that ManN and two N-glycosylation inhibitors stimulate EC proliferation via both JNK activation and th...
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#1Nicholas J. Protopsaltis (UCSD: University of California, San Diego)H-Index: 2
#2Wei Liang (UCSD: University of California, San Diego)H-Index: 10
Last. Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
view all 4 authors...
TH17 cells play important yet complex roles in cancer development and progression. We previously reported that TH17 cells and IL-17 mediate resistance to anti-VEGF therapy by inducing recruitment of immunosuppressive and proangiogenic myeloid cells to the tumor microenvironment. Here, we demonstrate that IL-22, a key effector cytokine expressed by TH17 cells, directly acts on endothelial cells to promote tumor angiogenesis. IL-22 induces endothelial cell proliferation, survival, and chemotaxis i...
9 CitationsSource
#1Wei Liang (UCSD: University of California, San Diego)H-Index: 10
#2Qin Li (UCSD: University of California, San Diego)H-Index: 6
Last. Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
view all 3 authors...
The tumor-promoting functions of neutrophils have been mainly attributed to induction of tumor angiogenesis or suppression of anticancer immunity. However, a direct impact of neutrophils on tumor cell growth and metastasis remains largely uncharacterized. Here, we coupled a proteomic approach with a functional screen to interrogate the secretome of tumor-associated neutrophils. Surprisingly, the iron-transporting protein transferrin was identified as the major mitogen for tumor cells secreted by...
23 CitationsSource
#1Sumanta K. Pal (City of Hope National Medical Center)H-Index: 60
#2Anh Pham (City of Hope National Medical Center)H-Index: 3
Last. Wei Liang (UCSD: University of California, San Diego)H-Index: 10
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Abstract Background Preclinical studies suggest that signal transducer and activator of transcription 3 (STAT3)-mediated recruitment of neutrophils to premetastatic tissue occurs prior to metastatic progression. Objective We sought to determine if neutrophilic infiltration in benign nodal tissue is associated with poor clinical outcome in patients with muscle-invasive bladder cancer. Design, setting, and participants Formalin-fixed, paraffin-embedded tissue was secured from 55 patients with musc...
2 CitationsSource
#1Wei Liang (UCSD: University of California, San Diego)H-Index: 10
#2Napoleone Ferrara (UCSD: University of California, San Diego)H-Index: 179
Chronic inflammation fosters cancer development and progression and also modulates tumor responses to anticancer therapies. Neutrophils are key effector cells in innate immunity and are known to play a critical role in various inflammatory disorders. However, the functions of neutrophils in cancer pathogenesis have been largely neglected until recently and still remain poorly characterized compared with other immune cells in the tumor microenvironment. We highlight recent findings on the mechani...
136 CitationsSource
#1Wang Zhang (Beckman Research Institute)H-Index: 12
#2Chunyan Zhang (Beckman Research Institute)H-Index: 21
Last. Hua Yu (Beckman Research Institute)H-Index: 68
view all 11 authors...
Increasing evidence suggests that premetastatic niches, consisting mainly of myeloid cells, provide microenvironment critical for cancer cell recruitment and survival to facilitate metastasis. While CD8+ T cells exert immunosurveillance in primary human tumors, whether they can exert similar effects on myeloid cells in the premetastatic environment is unknown. Here, we show that CD8+ T cells are capable of constraining premetastatic myeloid cell accumulation by inducing myeloid cell apoptosis in...
18 CitationsSource
#1Wei Wen (Beckman Research Institute)H-Index: 12
#2Wei Liang (Beckman Research Institute)H-Index: 10
Last. Richard Jove (Beckman Research Institute)H-Index: 38
view all 17 authors...
JAK/STAT3 is one of the major signaling pathways that is aberrantly activated in ovarian cancer and associated with tumor progression and poor prognosis in ovarian cancer patients. In this study, we evaluated the therapeutic potential of targeting JAK/STAT3 signaling in ovarian cancer using a peritoneal dissemination mouse model. We developed this mouse model by injecting a metastatic human ovarian cancer cell line, SKOV3-M-Luc, into the peritoneal cavity of immunodeficient mice. This model disp...
44 CitationsSource
#1Xianghui Fu (City of Hope National Medical Center)H-Index: 20
#2Zhipeng Meng (City of Hope National Medical Center)H-Index: 32
Last. Wendong Huang (City of Hope National Medical Center)H-Index: 52
view all 12 authors...
miR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis
77 CitationsSource
#1Wei Liang (City of Hope National Medical Center)H-Index: 10
#2Richard Jove (City of Hope National Medical Center)H-Index: 38
Last. Sumanta K. Pal (City of Hope National Medical Center)H-Index: 60
view all 8 authors...
e15522 Background: In preclinical models, NTPs appear to establish a pre-metastatic niche that fosters the invasion of metastases (Kowanetz et al. PNAS 2010). This observation still requires clinic...
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