Alexey A. Shadrin
Oslo University Hospital
GeneStatisticsGenome-wide association studyPhenotypeSNPBrain morphometrySingle-nucleotide polymorphismPsychologyMultivariate statisticsHeritabilityNeuroscienceGenetic associationFalse discovery rateBipolar disorderSchizophrenia (object-oriented programming)DiseaseLinkage disequilibriumGeneticsGenetic correlationComputational biologyMedicineSchizophreniaEvolutionary biologyBiologyGenetic architecture
Publications 55
#1Weiqiu Cheng (Oslo University Hospital)H-Index: 1
#2Oleksandr Frei (Oslo University Hospital)H-Index: 19
Last. Guy Hindley ('KCL': King's College London)H-Index: 4
view all 0 authors...
Importance null Schizophrenia is a complex heritable disorder associated with many genetic variants, each with a small effect. While cortical differences between patients with schizophrenia and healthy controls are consistently reported, the underlying molecular mechanisms remain elusive. null Objective null To investigate the extent of shared genetic architecture between schizophrenia and brain cortical surface area (SA) and thickness (TH) and to identify shared genomic loci. null Design, setti...
#1Torbjørn Elvsåshagen (Oslo University Hospital)H-Index: 20
#2Alexey A. Shadrin (Oslo University Hospital)H-Index: 12
Last. Tobias Kaufmann (Oslo University Hospital)H-Index: 35
view all 10 authors...
The thalamus is a vital communication hub in the center of the brain and consists of distinct nuclei critical for consciousness and higher-order cortical functions. Structural and functional thalamic alterations are involved in the pathogenesis of common brain disorders, yet the genetic architecture of the thalamus remains largely unknown. Here, using brain scans and genotype data from 30,114 individuals, we identify 55 lead single nucleotide polymorphisms (SNPs) within 42 genetic loci and 391 g...
#1Dennis van der MeerH-Index: 20
#2Alexey A. ShadrinH-Index: 12
Last. Tobias KaufmannH-Index: 35
view all 17 authors...
#1R. J. LoughnanH-Index: 4
#2Alexey A. ShadrinH-Index: 12
Last. Anders M. DaleH-Index: 2
view all 12 authors...
Genome-Wide Association studies have typically been limited to single phenotypes, given that high dimensional phenotypes incur a large multiple comparisons burden: ~1 million tests across the genome times the number of phenotypes. Recent work demonstrates that a Multivariate Omnibus Statistic Test (MOSTest) is well powered to discover genomic effects distributed across multiple phenotypes. Applied to cortical brain MRI morphology measures, MOSTest has resulted in a drastic improvement in power t...
#1Dominic Holland (UCSD: University of California, San Diego)H-Index: 49
#2Oleksandr Frei (University of Oslo)H-Index: 19
Last. Anders M. Dale (UCSF: University of California, San Francisco)H-Index: 2
view all 8 authors...
We propose an extended Gaussian mixture model for the distribution of causal effects of common single nucleotide polymorphisms (SNPs) for human complex phenotypes that depends on linkage disequilibrium (LD) and heterozygosity (H), while also allowing for independent components for small and large effects. Using a precise methodology showing how genome-wide association studies (GWASs) summary statistics (z-scores) arise through LD with underlying causal SNPs, we applied the model to GWAS of multi...
#1Ivan I. Maximov (Bergen University College)H-Index: 17
#2Dennis van der Meer (UM: Maastricht University)H-Index: 20
Last. Lars T. Westlye (University of Oslo)H-Index: 74
view all 8 authors...
Deriving reliable information about the structural and functional architecture of the brain in vivo is critical for the clinical and basic neurosciences. In the new era of large population-based datasets, when multiple brain imaging modalities and contrasts are combined in order to reveal latent brain structural patterns and associations with genetic, demographic and clinical information, automated and stringent quality control (QC) procedures are important. Diffusion magnetic resonance imaging ...
2 CitationsSource
#1Olav B. Smeland (Oslo University Hospital)H-Index: 22
#2Alexey A. Shadrin (Oslo University Hospital)H-Index: 12
Last. Ole A. Andreassen (Oslo University Hospital)H-Index: 123
view all 22 authors...
Abstract Background Parkinson’s disease (PD) and schizophrenia (SCZ) are heritable brain disorders that both involve dysregulation of the dopaminergic system. Epidemiological studies have reported potential comorbidity between the disorders, and movement disturbances are common in SCZ patients before treatment with antipsychotic drugs. Despite this, little is known about shared genetic etiology between the disorders. Methods We analyzed recent large genome-wide associations studies (GWAS) on SCZ...
2 CitationsSource
#1Alexey A. Shadrin (Oslo University Hospital)H-Index: 12
#2Sören Mucha (CAU: University of Kiel)H-Index: 10
Last. Manu Sharma (University of Tübingen)H-Index: 56
view all 36 authors...
Background Multiple system atrophy (MSA) is a rare neurodegenerative disease characterized by intracellular accumulations of α-synuclein and nerve cell loss in striatonigral and olivopontocerebellar structures. Epidemiological and clinical studies have reported potential involvement of autoimmune mechanisms in MSA pathogenesis. However, genetic etiology of this interaction remains unknown. We aimed to investigate genetic overlap between MSA and 7 autoimmune diseases and to identify shared geneti...
#1Shahram Bahrami (Oslo University Hospital)H-Index: 9
#2Alexey A. Shadrin (Oslo University Hospital)H-Index: 12
Last. Ole A. Andreassen (UCSD: University of California, San Diego)H-Index: 123
view all 15 authors...
Genome-wide association studies (GWAS) have identified several common genetic variants influencing major depression and general cognitive abilities, but little is known about whether the two share any of their genetic aetiology. Here we investigate shared genomic architectures between major depression (MD) and general intelligence (INT) with the MiXeR statistical tool and their overlapping susceptibility loci with conjunctional false discovery rate (conjFDR), which evaluate the level of overlap ...
#1Dennis van der Meer (University of Oslo)H-Index: 20
#1van der Meer (University of Oslo)H-Index: 1
Last. DaleH-Index: 1
view all 17 authors...
The folding of the human cerebral cortex is a highly genetically regulated process that allows for a much larger surface area to fit into the cranial vault and optimizes functional organization. Sulcal depth is a robust, yet understudied measure of localized folding, previously associated with a range of neurodevelopmental disorders. Here, we report the first genome-wide association study of sulcal depth. Through the Multivariate Omnibus Statistical Test (MOSTest) applied to vertex-wise measures...
1 CitationsSource