Cheng-Qin Liang
Guilin Medical University
TriterpenoidMonosaccharideCircular dichroismAntigenMolecular biologyOrganic chemistryChemistryGlycosideTwo-dimensional nuclear magnetic resonance spectroscopyIn vitroIn vivoVirusHBeAgCyclocaryaWestern blotRhodomyrtus tomentosaPaliurusHepatitis BHBsAgMyrtaceaeDuck hepatitis B virusBenzeneAntioxidantPhloroglucinolSyringic acidSilica gelDerivative (chemistry)ScrophulariaceaeDammaraneAntiviral drugTetraloneAntibacterial activityVerbascosideHepatitis B virusPhenylethanoidDPPHIridoid GlycosidesMicrosoriumStachys geobombycisLindernia ruellioidesInhibitory effectAntioxidant capacityIc50 valuesAnti hbva glucosidaseSpectroscopyChromatographyColumn chromatographyBacteriaTraditional medicineBotanyNuclear magnetic resonance spectroscopyHBxStereochemistryCell cultureBiologyPharmacology
8Publications
3H-index
20Citations
Publications 9
Newest
#1Qinghu Mo (GLMU: Guilin Medical University)H-Index: 1
#2Meng-Qi Yan (GLMU: Guilin Medical University)
Last. Cheng-Qin Liang (GLMU: Guilin Medical University)H-Index: 3
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Undescribed phloroglucinol derivatives, rhotomensones A-G, and a known derivative rhodomyrtosone B, were isolated from the leaves of Rhodomyrtus tomentosa. Rhotomensones A-D and G have unreported structural characteristics, in which rhotomensone A substitutes a benzene ring, rhotomensones B-D are bonded with a 2-methylbutanoyl group, and rhotomensone G has two fewer carbons. The structures of these compounds were determined by NMR spectroscopy, circular dichroism (CD) spectroscopy and X-ray crys...
1 CitationsSource
#1Qinghu Mo (GLMU: Guilin Medical University)H-Index: 1
#2Xian-Li Zhou (GLMU: Guilin Medical University)H-Index: 3
Last. Cheng-Qin Liang (GLMU: Guilin Medical University)H-Index: 3
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AbstractA new triterpenoid, 2α, 3β, 23α, 29-tetrahydroxyolean-11, 13 (18)-dien-28, 19β-olide, named as rhodotomoside A (1), together with six known triterpenoids (2–7), were isolated from the leave...
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#1Jun-Fei Mou (GLMU: Guilin Medical University)H-Index: 1
#2Xiao-Zhen Lin (Zhengzhou University)
Last. Xian-Li Zhou (GLMU: Guilin Medical University)H-Index: 3
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Although clinically approved hepatitis B virus (HBV) polymerase inhibitors (lamivudine-3TC, entecavir, etc.) serve as effective therapeutics, the virus can easily generate resistance to them. Therefore, the treatment of HBV infection remains a public health problem. Numerous studies have shown that natural products have prospective anti-HBV activity. The purpose of this study was to isolate and extract des(rhamnosyl) verbascoside from Lindernia ruellioides (Colsm.) Pennell and explore its anti-H...
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#1Xian-Li Zhou (GLMU: Guilin Medical University)H-Index: 3
#2Shan-Bin Li (GLMU: Guilin Medical University)
Last. Cheng-Qin Liang (GLMU: Guilin Medical University)H-Index: 3
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Abstract Thirteen undescribed dammarane triterpenoid saponins (cypaliurusides A–M), including eleven seco-dammarane type triterpenoids, were isolated from Cyclocarya paliurus. Each of these compounds has the unique feature of having a monosaccharide attached to C-11, rather than C-12, compared to the same type of saponins found in this plant. The structures of them were determined by comprehensive analysis of 1D, 2D NMR and HRESIMS data. Cypaliuruside J showed significant α-glucosidase inhibitor...
1 CitationsSource
#1Meng-Qi Yan (GLMU: Guilin Medical University)
#2Qin Luo (GLMU: Guilin Medical University)H-Index: 2
Last. Cheng-Qin Liang (GLMU: Guilin Medical University)H-Index: 3
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A new compound, 2-hydroxy-4-[3’,5’-dihydroxyhexyl]phenyl-β-D-glucopyranoside (1), together with five known compounds (2–6), were isolated from the leaves of Microsorium fortunei. Their structures were determined by spectroscopic techniques, especially 2D NMR and MS data analyses. All of these compounds are phenolic glycosides and were isolated from this plant for the first time. In addition, compound 1 showed moderate inhibitory activity against α-glucosidase with IC50 value at 0.111 ± 0.061 mg/...
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#1Huang Sixin (GLMU: Guilin Medical University)H-Index: 2
#2Jun-Fei Mou (GLMU: Guilin Medical University)H-Index: 1
Last. Cheng-Qin Liang (GLMU: Guilin Medical University)H-Index: 3
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Coumarins are widely present in a variety of plants and have a variety of pharmacological activities. In this study, we isolated a coumarin compound from Microsorium fortunei (Moore) Ching; the compound was identified as esculetin by hydrogen and carbon spectroscopy. Its anti-hepatitis B virus (HBV) activity was investigated in vitro and in vivo. In the human hepatocellular liver carcinoma 2.2.15 cell line (HepG2.2.15) transfected with HBV, esculetin effecting inhibited the expression of the HBV...
8 CitationsSource
#1Xian-Li Zhou (GLMU: Guilin Medical University)H-Index: 3
#2Huang Sixin (GLMU: Guilin Medical University)H-Index: 2
Last. Xu Chen (GLMU: Guilin Medical University)H-Index: 2
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AbstractA new derivative of syringic acid, stageobester A (1) and two iridoid glycosides which including a new one, stageoboside A (2), were isolated from the roots of Stachys geobombycis. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR and MS spectra. In addition, all the isolates were tested for their antioxidant capacity. Compounds 1 and 2 showed moderate antioxidant activities against DPPH radical, with IC50 values of 113.33 ± 1.53 and 40.33 ± ...
10 CitationsSource
#1Xian-Li Zhou (GLMU: Guilin Medical University)H-Index: 3
#2Qin Luo (GLMU: Guilin Medical University)H-Index: 2
Last. Xu Chen (GLMU: Guilin Medical University)H-Index: 2
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AbstractTwo new tetralone derivatives, named cyclopalosides A (1) and B (2), were isolated from the leaves of Cyclocarya paliurus by column chromatography on silica gel, reversed-phase C18 silica gel and preparative HPLC. Their chemical structures were established on the basis of extensive analyses of spectroscopic data. Their structural characteristic is tetralone glycoside with a caffeoyl unit. The antioxidant activities of compound 1 were evaluated by using hydroxyl, superoxide anion, and DPP...
1 CitationsSource
#1Jing-Chen Wei (GLMU: Guilin Medical University)H-Index: 1
#2Peng-Cheng Wang (GLMU: Guilin Medical University)H-Index: 2
Last. Xu Chen (GLMU: Guilin Medical University)H-Index: 2
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AbstractFive caffeoyl phenylethanoid glycosides, including two new ones linderruelliosides A (1) and B (2), were isolated from the leaves and stems of Lindernia ruellioides. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR and MS spectra. In addition, all these compounds were tested for their anti-HBV activity. Compounds 1, 3, and 4 showed anti-HBV activities, with IC50 values of 54.87, 30.74, and 69.02 μM for HBsAg and 26.70, 5.17, and 7.08 μM for ...
3 CitationsSource