Dongdong Li
Zhejiang University
DruggabilityProdrugMicelleCancerGene deliveryPhotothermal therapyChemistryTransdermalCombinatorial chemistryCell-penetrating peptideApocyninImmunotherapyEnhanced permeability and retention effectLesionTransplantationSurface coatingCancer researchVanadiumBovine serum albuminPharmacology
Publications 7
#1Dongdong Li (ZJU: Zhejiang University)H-Index: 4
#2Doudou Hu (ZJU: Zhejiang University)H-Index: 1
Last. Youqing Shen (ZJU: Zhejiang University)H-Index: 63
view all 9 authors...
Abstract Transdermal drug delivery exhibited encouraging prospects, especially through superficial drug administration routes. However, only a few limited lipophilic drug molecules could cross the skin barrier, those are with low molecular weight and rational Log P value. Microneedles (MNs) can overcome these limitations to deliver numerous drugs into the dermal layer by piercing the outermost skin layer of the body. In the case of superficial cancer treatments, topical drug administration faces...
3 CitationsSource
#1Doudou HuH-Index: 2
#2Dongdong LiH-Index: 4
Last. Youqing Shen (ZJU: Zhejiang University)H-Index: 63
view all 6 authors...
In the past few decades, various vanadium compounds have displayed potential in cancer treatment. However, fast clearness in the body and possible toxicity of vanadium compounds has hindered their further development. Vanadium-based nanomaterials not only overcome these limitations, but take advantage of the internal properties of vanadium in photics and magnetics, which enable them as a multimodal platform for cancer diagnosis and treatment. In this paper, we first introduced the basic biologic...
1 CitationsSource
#1Jingkai Wang (ZJU: Zhejiang University)H-Index: 11
#2Dongdong Li (ZJU: Zhejiang University)H-Index: 4
Last. Youqing Shen (ZJU: Zhejiang University)H-Index: 63
view all 16 authors...
Spinal cord injury (SCI) is a devastating disorder, leading to permanent motor and sensory deficit. Despite recent advances in neurosciences, the treatment efficacy on SCI patients remains unsatisfactory, mainly due to the poor accumulation, short retention, and lack of controlled release of therapeutics in lesion tissue. Herein, an injured spinal cord targeting prodrug polymer micelle is built. An esterase-responsive bond is used to link apocynin (APO) monomer, because of the enhanced esterase ...
3 CitationsSource
#1Ding Hu (ZJU: Zhejiang University)H-Index: 2
#2Hongxia Xu (ZJU: Zhejiang University)H-Index: 3
Last. Youqing Shen (ZJU: Zhejiang University)H-Index: 63
view all 8 authors...
Many metal–organic complexes showed potent anticancer efficacy, but their clinical applications were limited by the lack of administration route because of their poor solubility. To make metal–organic nanoparticles (MONPs) comprising metal complex drugs is a new formulation strategy for their administration. Herein, we developed a facile synthesis of an MONP composed of bovine serum albumin (BSA), Cu2+, and an anticancer agent, 5-nitro-8-hydroxyquinoline (NQ) with albumin as a nanoreactor. The r...
12 CitationsSource
#1Fan Xu (CAS: Chinese Academy of Sciences)H-Index: 5
#2Huihai Zhong (CAS: Chinese Academy of Sciences)H-Index: 4
Last. Yongzhuo Huang (CAS: Chinese Academy of Sciences)H-Index: 32
view all 10 authors...
Abstract Chemoresistance remains a formidable hurdle against cancer therapy. Seeking for novel therapy strategies is an urgent need for those who no longer benefit from chemotherapy. Chemoresistance is usually associated with the dysfunction of intrinsic apoptosis. Targeting extrinsic apoptosis via TRAIL signaling and the death receptors could be a potential solution to treat chemoresistant cancer. A highly biocompatible nano system for codelivery of the TRAIL DNA and the death receptor sensitiz...
22 CitationsSource
#1Dongdong Li (CAS: Chinese Academy of Sciences)H-Index: 4
#2Meng Zhang (CAS: Chinese Academy of Sciences)H-Index: 31
Last. Yongzhuo Huang (CAS: Chinese Academy of Sciences)H-Index: 32
view all 9 authors...
Abstract Nanotechnology-based photothermal therapy has attracted great attention in the past decade. Nevertheless, photothermal therapy has some inherent drawbacks, such as the uneven heat production and limited laser penetration, often leading to insufficient treatment outcomes. Here, we developed a combination strategy to improve cancer therapy. The biomimetic albumin-modified gold nanorods (AuNRs) were prepared with incorporation of paclitaxel (PTX). This therapeutic system was characterized ...
33 CitationsSource
#1Yingzhi ChenH-Index: 9
#2Meng Zhang (CAS: Chinese Academy of Sciences)H-Index: 56
Last. Yongzhuo HuangH-Index: 32
view all 8 authors...
: Malignant glioma is one of the most untreatable cancers because of the formidable blood-brain barrier (BBB), through which few therapeutics can penetrate and reach the tumors. Biologics have been booming in cancer therapy in the past two decades, but their application in brain tumor has long been ignored due to the impermeable nature of BBB against effective delivery of biologics. Indeed, it is a long unsolved problem for brain delivery of macromolecular drugs, which becomes the Holy Grail in ...
20 CitationsSource
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