Damian Tolan
Leeds Teaching Hospitals NHS Trust
Internal medicineRadiologySurgeryMagnetic resonance imagingUltrasoundIntensive care medicineProspective cohort studyRadiological weaponMedical physicsFistulaColonoscopyDiseaseCrohn's diseaseMEDLINENeuroradiologyGuidelineRectumPopulationNuclear medicineComputer scienceInterventional radiologyColorectal cancerComputed tomographyGeneral surgeryMedicineCohortGastroenterology
78Publications
18H-index
1,957Citations
Publications 80
Newest
#1G.R. Iball (LGI: Leeds General Infirmary)
#2Damian TolanH-Index: 18
Last. P. Woolfall (University Hospital of North Tees)
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AIM To audit scanning technique and patient doses for computed tomography (CT) colonography (CTC) examinations in a large UK region and to identify opportunities for quality improvement. MATERIALS AND METHODS Scanning technique and patient dose data were gathered for both contrast-enhanced and unenhanced CTC examinations from 33 imaging protocols across 27 scanners. Measurements of patient weight and effective diameter were also obtained. Imaging protocols were compared to identify technique dif...
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#1G Wilcox (Leeds Teaching Hospitals NHS Trust)
#2John C. Taylor (University of Leeds)H-Index: 21
Last. Damian Tolan (Leeds Teaching Hospitals NHS Trust)H-Index: 18
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#1Stephen J Chapman (University of Leeds)H-Index: 17
Last. David Jayne (University of Leeds)H-Index: 25
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Introduction null Ileus is a common and distressing condition characterised by gut dysfunction after surgery. While a number of interventions have aimed to curtail its impact on patients and healthcare systems, ileus is still an unmet challenge. Electrical stimulation of the vagus nerve is a promising new treatment due to its role in modulating the neuro-immune axis through a novel anti-inflammatory reflex. The protocol for a feasibility study of non-invasive vagus nerve stimulation (nVNS), and ...
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#1Gemma Ruth Armstrong (University of Leeds)
#2Mohammed Ibrahim Khot (University of Leeds)
Last. David Jayne (University of Leeds)H-Index: 25
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Background: Curative resection of colon cancer requires accurate intraoperative identification of tumour margins and lymph node (LN) burden. The c-Met protein is important for cell differentiation and migration and is overexpressed in many gastrointestinal cancers. We explored EMI-137, a novel c-Met targeting fluorescent probe, for application in fluorescence-guided colon surgery, in HT-29 colorectal cancer (CRC) cell line and an in vivo murine model. This informed a first-in-man clinical trial ...
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#1Nicholas E Burr (Leeds Teaching Hospitals NHS Trust)H-Index: 14
#2Andrew Plumb (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 19
Last. Damian Tolan (Leeds Teaching Hospitals NHS Trust)H-Index: 18
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We read with interest the recent article by Cash et al comparing colon capsule (CCE) and CT colonography (CTC) with optical colonoscopy (OC) for detecting colonic polyps and colorectal cancer (CRC) in a screening population.1 The study reports low CTC detection rates for ≥6 mm and ≥10 mm polyps of only 8.6% and 6.3%, respectively. These were much lower than the detection rates seen for CCE and OC. These results contradict larger trials, where the performance of CTC and OC tests are similar. The ...
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#1David Jayne (University of Leeds)H-Index: 25
#2John H. Scholefield (University of Nottingham)H-Index: 61
Last. Laura Magill (University of Birmingham)H-Index: 13
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OBJECTIVE To undertake a randomized comparison of the Biodesign Surgisis anal fistula plug against surgeon's preference in treating cryptoglandular transsphincteric fistula-in-ano. SUMMARY BACKGROUND DATA The efficacy of the Biodesign Surgisis anal fistula plug in healing anal fistulae is uncertain. METHODS Participants were randomized to the fistula plug with surgeon's preference (advancement flap, cutting seton, fistulotomy, Ligation of the Intersphincteric Fistula Tract procedure). The primar...
8 CitationsSource
#1J. R. Burke (St James's University Hospital)H-Index: 1
#2P.J. Brown (Leeds Teaching Hospitals NHS Trust)H-Index: 2
Last. P. SagarH-Index: 1
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BACKGROUND The growth pattern of colorectal cancer is seldom investigated. This cohort study aimed to explore tumour growth rate in colorectal cancers managed non-surgically or deemed not resectable, and to determine its implication for prognosis. METHODS Consecutive patients with colonic or rectal adenocarcinoma were identified through the colorectal multidisciplinary team database at Leeds Teaching Hospitals NHS Trust over a 2-year interval. Patients who received no treatment (surgery, stentin...
3 CitationsSource
#1Hema Sekhar (University of Manchester)H-Index: 2
#2Rohit KochharH-Index: 8
Last. Andrew G Renehan (University of Manchester)H-Index: 66
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The primary aim was to test the hypothesis that deriving pre-treatment 3D magnetic resonance tumour volume (mrTV) quantification improves performance characteristics for the prediction of loco-regional failure compared with standard maximal tumour diameter (1D) assessment in patients with squamous cell carcinoma of the anus undergoing chemoradiotherapy. We performed an early evaluation case-control study at two UK centres (2007–2014) in 39 patients with loco-regional failure (cases), and 41 pati...
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#1Damian TolanH-Index: 18
#2Rachel HylandH-Index: 1
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#1Damian TolanH-Index: 18
#2Rachel HylandH-Index: 1
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