Kaitlyn Waters
University of Missouri
Protein subunitPhenotypeViral sheddingPhenotypic traitViral replicationViral pathogenesisMutantAdaptationVirologyReassortmentEnzymeHost tropismVirusTransmission (medicine)Canine influenzaInfluenza A virusHemagglutinin (influenza)PathogenesisPopulationReassortant VirusesRibonucleoprotein complexPotential riskInfluenza aTissue tropismTranscription (biology)Affect (psychology)Active siteInfluenza A virus subtype H5N1GeneticsPolymeraseBiology
5Publications
3H-index
11Citations
Publications 6
Newest
#1Kaitlyn WatersH-Index: 3
#2Cheng Gao (MU: University of Missouri)
Last. Xiu-Feng WanH-Index: 32
view all 7 authors...
Compatibility among the influenza A virus (IAV) ribonucleoprotein (RNP) genes affects viral replication efficiency and can limit the emergence of novel reassortants, including those with potential pandemic risks. In this study, we determined the polymerase activities of 2,451 RNP reassortants among three seasonal and eight enzootic IAVs by using a minigenome assay. Results showed that the 2009 H1N1 RNP are more compatible with the tested enzootic RNP than seasonal H3N2 RNP and that triple reasso...
Source
#1Kaitlyn Waters (MU: University of Missouri)H-Index: 3
#2Hamilton J Wan (MU: University of Missouri)H-Index: 2
Last. Xiu-Feng WanH-Index: 32
view all 7 authors...
Abstract PB1 functions as the catalytic subunit of influenza virus RNA polymerase complex and plays an essential role in viral RNA transcription and replication. To determine plasticity in the PB1 enzymatic site and map catalytically important residues, 658 mutants were constructed, each with one to seven mutations in the enzymatic site of PB1. The polymerase activities of these mutants were quantified using a minigenome assay, and polymerase activity-associated residues were identified using sp...
Source
#1Xiaojian Zhang (MU: University of Missouri)H-Index: 3
#2Fred L. Cunningham (APHIS: Animal and Plant Health Inspection Service)H-Index: 17
Last. Xiu-Feng WanH-Index: 32
view all 14 authors...
Wild aquatic birds maintain a large, genetically diverse pool of influenza A viruses (IAVs), which can be transmitted to lower mammals and, ultimately, humans. Through phenotypic analyses of viral replication efficiency, only a small set of avian IAVs were found to replicate well in epithelial cells of the swine upper respiratory tract, and these viruses were shown to infect and cause virus shedding in pigs. Such a phenotypic trait of the viral replication efficiency appears to emerge randomly a...
Source
#1Xiaojian Zhang (MU: University of Missouri)H-Index: 3
#2Frederick Cummingham (APHIS: Animal and Plant Health Inspection Service)H-Index: 1
Last. Xiu-Feng Wan (MSU: Mississippi State University)H-Index: 32
view all 14 authors...
Wild aquatic birds maintain a large genetically diverse pool of influenza A viruses (IAVs), which can be transmitted to lower mammals and ultimately humans. Through phenotypic analyses, only a small set of avian IAVs replicated well in the epithelial cells of swine upper respiratory tracts, and these viruses were shown to infect and cause virus shedding in pigs. Such a phenotypic trait appears to emerge randomly and are distributed among IAVs across multiple avian species, geographic and tempora...
Source
#1Hailiang SunH-Index: 11
#2Sherry Blackmon (MSU: Mississippi State University)H-Index: 6
Last. Xiu-Feng WanH-Index: 32
view all 16 authors...
Source
#1Hailiang Sun (MSU: Mississippi State University)H-Index: 11
#2Sherry Blackmon (MSU: Mississippi State University)H-Index: 6
Last. Xiu-Feng Wan (MSU: Mississippi State University)H-Index: 32
view all 16 authors...
ABSTRACT Two subtypes of influenza A virus (IAV), avian-origin canine influenza virus (CIV) H3N2 (CIV-H3N2) and equine-origin CIV H3N8 (CIV-H3N8), are enzootic in the canine population. Dogs have been demonstrated to seroconvert in response to diverse IAVs, and naturally occurring reassortants of CIV-H3N2 and the 2009 H1N1 pandemic virus (pdmH1N1) have been isolated. We conducted a thorough phenotypic evaluation of CIV-H3N2 in order to assess its threat to human health. Using ferret-generated an...
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