Robert G. E. Holgate
Scientific evidenceInternational Nonproprietary NameAntibodyEpitopeIn vitroImmunologyEx vivoIn silicoT cellHumanized antibodyCD52B cellIdentity (object-oriented programming)AlemtuzumabImmunogenicityScientific literatureDeimmunizationExpert groupMonoclonal antibodyDrug developmentComputational biologyMedicineBiologyImmune system
Publications 3
#1Tim JonesH-Index: 8
Last. Matthew BakerH-Index: 18
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An important step in drug development is the assignment of an International Nonproprietary Name (INN) by the World Health Organization (WHO) that provides healthcare professionals with a unique and universally available designated name to identify each pharmaceutical substance. Monoclonal antibody INNs comprise a –mab suffix preceded by a substem indicating the antibody type, e.g., chimeric (-xi-), humanized (-zu-), or human (-u-). The WHO publishes INN definitions that specify how new monoclona...
43 CitationsSource
#2Richard WeldonH-Index: 5
Last. Matthew BakerH-Index: 18
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Anti-CD52 therapy has been shown to be effective in the treatment of a number of B cell malignancies, hematopoietic disorders and autoimmune diseases (including rheumatoid arthritis and multiple sclerosis); however the current standard of treatment, the humanized monoclonal antibody alemtuzumab, is associated with the development of anti-drug antibodies in a high proportion of patients. In order to address this problem, we have identified a novel murine anti-CD52 antibody which has been humanize...
24 CitationsSource
: The development of anti-therapeutic antibody immune responses can limit efficacy and reduce the safety of antibody treatments. Despite significant advances to minimize such immune responses, these responses still occur, even against fully human antibodies. Thus, the ability to assess the immunogenic potential of a therapeutic antibody can provide significant benefits during the development cycle of a therapeutic protein, and may lead to the future development of therapeutic antibodies that pos...
31 Citations
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