Yumeng Zhang
Shenyang Pharmaceutical University
ExcretionPharmacodynamicsPharmacokineticsPhosphorylationSolubilityBioavailabilityChemistryApoptosisIn vivoCedrolInflammationOral administrationHeLaMetaboliteRheumatoid arthritisGinsengDammaraneHepatic fibrosisChromatographyStereochemistryMedicineCancer cellPharmacology
14Publications
4H-index
27Citations
Publications 12
Newest
#1Meng Ding (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Yumeng Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 4
Last. Yuqing Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 16
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Abstract Our previous study suggests a well-defined pharmacological activity of 20(R)-25-methoxyl-dammarane-3β,12β,20-triol (AD-1) and its metabolite 20(R)-dammarane-3β,12β,20,25-tetrol (AD-2). The current study aims to investigate the gender-related differences in pharmacokinetics, tissue distribution, and excretion of AD-1 and its metabolite in both male and female rats. A sensitive and rapid ultra-performance liquid chromatography tandem mass spectrometric (UPLC-MS/MS) method was developed fo...
3 CitationsSource
#1Meng Ding (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Lei Xu (Yanbian University)H-Index: 2
Last. Yuqing Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 1
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Abstract This research, for the first time, obtained and reported three novel Form I, Form II, and Form III of 20(R)-25-methoxyl-dammarane-3 β ,12 β ,20-triol polymorphs, which were distinguished by PXRD, IR, DSC, and SEM. This study firstly exploited a rapid and feasible UHPLC-ESI-MS/MS method to determine plasma levels of 20(R)-25-OCH 3 -PPD within 4.5 min. The composition of mobile phase was acetonitrile and 5 mM ammonium acetate water (85:15, v/v) at a flow rate of 0.2 mL/min on the BEH C 18...
2 CitationsSource