Qi Wang
Guangzhou University of Chinese Medicine
Internal medicineEndocrinologyRandomized controlled trialChemistryApoptosisImmunologyIn vivoNeuroprotectionOxidative stressPiperaquineSystems pharmacologyMorris water navigation taskCancer researchMedicineProtein kinase BPI3K/AKT/mTOR pathwayBiologyMeta-analysisCell biologyPharmacology
219Publications
22H-index
2,025Citations
Publications 217
Newest
#1Dan-Hua He (Guangzhou University of Chinese Medicine)H-Index: 2
#2Yu-Fei Chen (Guangzhou University of Chinese Medicine)
Last. Yongqiang Liu (Guangzhou University of Chinese Medicine)H-Index: 5
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Skp2 is overexpressed in multiple cancers and plays a critical role in tumor development through ubiquitin/proteasome-dependent degradation of its substrate proteins. Drugs targeting Skp2 have exhibited promising anticancer activity. Here, we identified a plant-derived Skp2 inhibitor, betulinic acid (BA), via high-throughput structure-based virtual screening of a phytochemical library. BA significantly inhibited the proliferation and migration of non-small cell lung cancer (NSCLC) through target...
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#1Shuoyi Jiang (Guangzhou Medical University)
#2Xiao-ge Wang (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Xinliang MaoH-Index: 29
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Chronic myelogenous leukemia (CML) is a clonal malignancy of hematopoietic stem cells featured with the fusion protein kinase BCR-ABL. To elicit the mechanism underlying BCR-ABL stability, we perform a screen against a panel of deubiquitinating enzymes (DUBs) and find that the ubiquitin-specific protease 7 (USP7) drastically stabilizes the BCR-ABL fusion protein. Further studies show that USP7 interacts with BCR-ABL and blocks its polyubiquitination and degradation. Moreover, USP7 knockdown trig...
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Aberrant activation of the Hedgehog (Hh) pathway is implicated in the pathogenesis and development of multiple cancers, especially Hh-driven medulloblastoma (MB). Smoothened (SMO) is a promising therapeutic target of the Hh pathway in clinical cancer treatment. However, SMO mutations frequently occur, which leads to drug resistance and tumor relapse. Novel inhibitors that target both the wild-type and mutant SMO are in high demand. In this study, we identified a novel Hh pathway inhibitor, pseud...
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#1Yunxia LuoH-Index: 4
#2Hansen Chen (Li Ka Shing Faculty of Medicine, University of Hong Kong)H-Index: 14
Last. Jiangang ShenH-Index: 47
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Danggui-Shayao-San (DSS) is a famous Traditional Chinese Medicine formula that used for treating pain disorders and maintaining neurological health. Recent studies indicate that DSS has neuroprotective effects against ischemic brain damage but its underlining mechanisms remain unclear. Herein, we investigated the neuroprotective mechanisms of DSS for treating ischemic stroke. Adult male Sprague-Dawley (S.D.) rats were subjected to 2 h of middle cerebral artery occlusion (MCAO) plus 22 h of reper...
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#1Xiaotian JiH-Index: 1
#2Yousheng MoH-Index: 7
view all 9 authors...
Metal-organic frameworks (MOFs) as promising materials have been widely used in drug delivery, disease diagnosis and therapy; however, their effects on the reproductive system remain unknown, which hinders their further clinical applications. Here we show that repeated subcutaneous injections of copper MOFs (HKUST-1) induce higher toxicity into the male reproductive system relative to the female reproductive system, with disrupted seminiferous tubule histology, sperm generation disorder, irrever...
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#2Ying Zhang (Guangzhou University of Chinese Medicine)
Last. Qi WangH-Index: 22
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Intracerebral hemorrhage (ICH) is a subtype of stroke characterized by high mortality and disability rates. To date, the exact etiology of ICH-induced brain injury is still unclear. Moreover, there is no effective treatment to delay or prevent disease progression currently. Increasing evidence suggests that ferroptosis plays a dominant role in the pathogenesis of ICH injury. Baicalin is a main active ingredient of Chinese herbal medicine Scutellaria baicalensis. It has been reported to exhibit n...
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#1Wanling Zhao (Guangzhou University of Chinese Medicine)H-Index: 1
#2Jinqiong Deng (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Sijun Liu (Guangzhou University of Chinese Medicine)H-Index: 1
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Metal–organic frameworks (MOFs), which are also referred to as coordination polymers, have been widely used in adsorption separation and catalysis, especially in the field of physical chemistry in ...
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#1Sha XiongH-Index: 5
#2Jingshan LuoH-Index: 3
Last. Tongkai Chen (Guangzhou University of Chinese Medicine)H-Index: 12
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There has been an exponential increase in the rate of incidence of Parkinson's disease (PD) with aging in the global population. PD, the second most common neurodegenerative disorder, results from damaged dopamine neurons in the substantia nigra pars compacta (SNpc), along with the deposition of abnormal α-synuclein (α-Syn), and the progressive degeneration of neurons in striatal regions. Despite extensive investigations to understand the pathophysiology of PD to develop effective therapies to r...
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#1Meiling Zhou (SYSU: Sun Yat-sen University)
Last. Hong Zhang (Guangzhou University of Chinese Medicine)
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Ageing population is a tough task worldwide, and the aggravating trend of ageing population in China brings enormous pressure to healthcare system. Chinese acupuncture has shown definite anti-ageing effect as arthralgia relief, movement improvement, energy increase and immunity enhancement; however, the mechanisms underlying are far away from illumination. Increasing literature has highlighted the role of alterations in mitochondrial function as a potential central regulator in ageing biology; m...
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Last. Dianjing Guo (CUHK: The Chinese University of Hong Kong)H-Index: 1
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Glandular trichome (GT) is the dominant site for artemisinin production in Artemisia annua. Several critical genes involved in artemisinin biosynthesis are specifically expressed in GT. However, the molecular mechanism of differential gene expression between GT and other tissue types remains elusive. Chromatin accessibility, defined as the degree to which nuclear molecules are able to interact with chromatin DNA, reflects gene expression capacity to a certain extent. Here, we investigated and co...
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