Meng Ding
Shenyang Pharmaceutical University
ExcretionCytotoxicityPharmacokineticsChemical synthesisBiological activityAmes testCancerSapogeninInternal medicineEndocrinologyNuclear chemistrySolubilityAdipose tissueBioavailabilityChemistryMetabolic pathwayAdverse effectTHP1 cell lineIn vivoCedrolGinsenosideAcetic acidBeagleOral administrationHeLaAcetonitrileMetaboliteCholesterolTriglycerideGenotoxicityGinsengMitomycin CLow-density lipoproteinDammaraneEthyl acetateUrineEthanolProstate cancerPancreatic cancerOvarian cancerAmmonium acetateMTT assayPanax notoginsengAcetoneDiallyl trisulfideCarrageenanTriolTriterpenoid saponinGarlic OilToxicityPlasma levelsUhplc ms msMicronucleusMicronucleus testObesityColumn chromatographyColorectal cancerBreast cancerBiochemistryStereochemistryMedicineCell cultureCancer cellPharmacology
8Publications
3H-index
24Citations
Publications 8
Newest
#1Wei Li (SPU: Shenyang Pharmaceutical University)H-Index: 1
#1Wei Li (SPU: Shenyang Pharmaceutical University)H-Index: 33
Last. Yuqing Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 1
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Abstract Background Ginsenosides have been widely used clinically for many years and were regarded as very safe. However, a few researches on the toxicities of these kinds of agents showed that some ginsenosides may have side-effect on the rats or dogs. So it is extremely necessary to further clarify the potential toxicity of ginsenosides. This study was carried out to investigate long-term toxicity and genotoxicity of 25-methoxydammarane-3, 12, 20-triol (25-OCH3-PPD), a new derivative of ginsen...
2 CitationsSource
#1Ziyi Wang (SPU: Shenyang Pharmaceutical University)H-Index: 2
#2Meng Ding (SPU: Shenyang Pharmaceutical University)H-Index: 3
Last. Yuqing Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 16
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: Panaxadiol is a dammarane-type ginsenoside having high ginseng content. The 3-hydroxy group of panaxadiol (PD) was modified by fatty acids and diacids. The modified panax glycol had enhanced anticancer activity. Twelve PD derivatives were evaluated and purified by chemical synthesis, column chromatography, co-synthesis, and identification. The human leukemia cells THP-1, HL-60, and human prostate cancer cell lines PC-3 were evaluated; PD derivatives were tested and evaluated in vitro by MTT as...
3 CitationsSource
#1Meng Ding (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Xude Wang (SPU: Shenyang Pharmaceutical University)H-Index: 5
Last. Yuqing Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 16
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Abstract 20(R)-25-methoxyl-dammarane-3 β ,12 β ,20-triol (AD-1, CN Patent: 201010107476.7) is a novel derivative of dammarane-type ginsenoside. AD-1 has been shown to inhibit cancer cell proliferation without significant host toxicity in vivo , and has excellent development potential as a new anti-cancer agent. This study was designed systematically to explore the metabolic pathway of ginseng sapogenins. The metabolism of drugs in the body is a complex biotransformation process where drugs are s...
4 CitationsSource
#1Yumeng Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Lei Xu (Yanbian University)H-Index: 2
Last. Yuqing Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 16
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Abstract Ethnopharmacological relevance Shenque is an acupoint located in the umbilicus and connected with the meridians. Thus, acupoint herbs applied at Shenque plays a pivotal role in the Chinese traditional medicine due to its sensitivity, permeability, and absorption. Many studies reported the use of Shenque point as a successful therapeutic approach. However, the effect of garlic oil (GO) applied at Shenque point to combat obesity is unmet. Consequently, we investigated the potential benefi...
4 CitationsSource
#1Jie-wen Wang (SPU: Shenyang Pharmaceutical University)H-Index: 2
#2Shan-Shan Chen (SPU: Shenyang Pharmaceutical University)H-Index: 4
Last. Yuqing Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 16
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Abstract Alternate forms of drug crystals display different physicochemical properties. These include stability, dissolution rate, bioavailability and solubility, which can affect pharmacokinetics and pharmacodynamics. It is therefore important to compare the crystal forms of cedrol to obtain optimal anti-inflammatory and analgesic effects. This study, for the first time, obtained and reports three novel forms (I-III) of cedrol polymorphs. The three forms of cedrol were recrystallized from seven...
6 CitationsSource
#1Meng Ding (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Yumeng Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 4
Last. Yuqing Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 16
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Abstract Our previous study suggests a well-defined pharmacological activity of 20(R)-25-methoxyl-dammarane-3β,12β,20-triol (AD-1) and its metabolite 20(R)-dammarane-3β,12β,20,25-tetrol (AD-2). The current study aims to investigate the gender-related differences in pharmacokinetics, tissue distribution, and excretion of AD-1 and its metabolite in both male and female rats. A sensitive and rapid ultra-performance liquid chromatography tandem mass spectrometric (UPLC-MS/MS) method was developed fo...
3 CitationsSource
#1Meng Ding (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Lei Xu (Yanbian University)H-Index: 2
Last. Yuqing Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 1
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Abstract This research, for the first time, obtained and reported three novel Form I, Form II, and Form III of 20(R)-25-methoxyl-dammarane-3 β ,12 β ,20-triol polymorphs, which were distinguished by PXRD, IR, DSC, and SEM. This study firstly exploited a rapid and feasible UHPLC-ESI-MS/MS method to determine plasma levels of 20(R)-25-OCH 3 -PPD within 4.5 min. The composition of mobile phase was acetonitrile and 5 mM ammonium acetate water (85:15, v/v) at a flow rate of 0.2 mL/min on the BEH C 18...
2 CitationsSource
#2Meng DingH-Index: 3
Last. Yuqing ZhaoH-Index: 16
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25-Methoxyl-dammarane-3β,12β,20-triol (25-OCH3-PPD), a dammarane-type triterpene sapogenin isolated from Panax notoginseng, has shown strong antitumor effects in various human cancer cell lines, including prostate cancer, lung cancer, breast cancer, gastric cancer, colorectal cancer, pancreatic cancer, and hepatic fibrosis. This review focuses on the progress of research into 25-OCH3-PPD and its derivatives in cancer therapy, including in vitro and in vivo activities, structure-activity relation...
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