Karen Miller
Cardiac function curveInternal medicineSurgeryCardiologyCoronary circulationBleedUmbilical cordCardiac catheterizationHeart failureVentricleStem-cell therapyHypoplastic left heart syndromeContext (language use)Heart diseaseCell basedPhases of clinical researchMedicineEjection fraction
Publications 3
#1Patrick W. O'Leary (Mayo Clinic)H-Index: 41
#2M. Yasir Qureshi (Mayo Clinic)H-Index: 5
Last. Angela R. MillerH-Index: 2
view all 15 authors...
Abstract null null Objective null To define the impact of tricuspid valve cone reconstruction (CR) on ventricular performance in Ebstein anomaly, both independently and after stem cell therapy. null null null Patients and Methods null The control group included 257 patients who had CR between June 2007 and December 2019. Ten subjects of a phase I stem cell therapy trial (May 2017 – March 2019) were compared with the controls to assess the echocardiographic impact on ventricular remodeling. null ...
Abstract Objectives Staged surgical palliation for hypoplastic left heart syndrome results in an increased workload on the right ventricle serving as the systemic ventricle. Concerns for cardiac dysfunction and long-term heart failure have generated interest in first-in-infant, cell-based therapies as an additional surgical treatment modality. Methods A phase 1 clinical trial was conducted to evaluate the safety and feasibility of direct intramyocardial injection of autologous umbilical cord blo...
#1Muhammad Yasir Qureshi (Mayo Clinic)H-Index: 12
#2Allison K. Cabalka (Mayo Clinic)H-Index: 31
Last. Karen MillerH-Index: 2
view all 19 authors...
Abstract Myocardial dysfunction after Fontan palliation for univentricular congenital heart disease is a challenging clinical problem. The medical treatment has a limited impact, with cardiac transplant being the ultimate management step. Cell-based therapies are evolving as a new treatment for heart failure. Phase 1 clinical trials using regenerative therapeutic strategies in congenital heart disease are ongoing. We report the first case of autologous bone marrow–derived mononuclear cell admini...
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