M. Sadman Sakib
German Center for Neurodegenerative Diseases
CorticogenesisHippocampal formationVirologyNeuroscienceCognitionChemistryEpitopeModel organismProgenitor cellPathologicalMajor histocompatibility complexNeurodegenerationHeart failureImpaired memoryCognitive declineMemory impairmentEpigeneticsBiochemistryMedicineBiologyImmune systemCell biology
13Publications
6H-index
233Citations
Publications 12
Newest
#1Pauline Antonie Ulmke (GAU: University of Göttingen)H-Index: 2
#2M. Sadman Sakib (German Center for Neurodegenerative Diseases)H-Index: 6
Last. Tran Tuoc (GAU: University of Göttingen)H-Index: 16
view all 15 authors...
Summary Intermediate progenitor cells (IPCs) are neocortical neuronal precursors. Although IPCs play crucial roles in corticogenesis, their molecular features remain largely unknown. In this study, we aimed to characterize the molecular profile of IPCs. We isolated TBR2-positive (+) IPCs and TBR2-negative (−) cell populations in the developing mouse cortex. Comparative genome-wide gene expression analysis of TBR2+ IPCs versus TBR2− cells revealed differences in key factors involved in chromatid ...
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#1M. Sadman Sakib (German Center for Neurodegenerative Diseases)H-Index: 6
#2Godwin Sokpor (RUB: Ruhr University Bochum)H-Index: 1
Last. Tran Tuoc (RUB: Ruhr University Bochum)H-Index: 16
view all 5 authors...
Cell sorting can be used to purify cell populations for cell type-specific molecular probing. Fluorescence-activated cell sorting (FACS) coupled with high-throughput sequencing affords molecular signature identification for specific cell types. FACS has many challenges that limit comprehensive cell purification from the brain, leading to incomplete molecular characterization. Here, we present the intranuclear immunostaining-based FACS protocol with several modified steps, which allows optimized ...
2 CitationsSource
#1Rezaul Islam (German Center for Neurodegenerative Diseases)H-Index: 6
#2Dawid Lbik (GAU: University of Göttingen)H-Index: 3
Last. Andre Fischer (GAU: University of Göttingen)H-Index: 49
view all 15 authors...
In current clinical practice, care of diseased patients is often restricted to separated disciplines. However, such an organ-centered approach is not always suitable. For example, cognitive dysfunction is a severe burden in heart failure patients. Moreover, these patients have an increased risk for age-associated dementias. The underlying molecular mechanisms are presently unknown, and thus, corresponding therapeutic strategies to improve cognition in heart failure patients are missing. Using mi...
1 CitationsSource
#1Rezaul Islam (German Center for Neurodegenerative Diseases)H-Index: 6
#2Dawid Lbik (GAU: University of Göttingen)H-Index: 3
Last. Andre Fischer (GAU: University of Göttingen)H-Index: 49
view all 14 authors...
In current clinical practice care of diseased patients is often restricted to separated disciplines. However, such an organ-centered approach is not always suitable. For example, cognitive dysfunction is a severe burden in heart failure patients. Moreover, these patients have an increased risk for age-associated dementias. The underlying molecular mechanisms are presently unknown and thus corresponding therapeutic strategies to improve cognition in heart failure patients are missing. Using mice ...
Source
#1Inga Urban (MPG: Max Planck Society)H-Index: 3
#2Cemil Kerimoglu (German Center for Neurodegenerative Diseases)H-Index: 15
Last. Gregor Eichele (MPG: Max Planck Society)H-Index: 67
view all 10 authors...
Aberrant histone acetylation contributes to age-dependent cognitive decline and neurodegenerative diseases. We analyze the function of lysine acetyltransferase TIP60/KAT5 in neurons of the hippocampus using an inducible mouse model. TIP60-deficiency in the adult forebrain leads within days to extensive transcriptional dysfunction characterized by the presence of a neurodegeneration-related signature in CA1. Cell cycle- and immunity-related genes are upregulated while learning- and neuronal plast...
4 CitationsSource
#1David Baidoe-Ansah (German Center for Neurodegenerative Diseases)H-Index: 1
#2M. Sadman Sakib (German Center for Neurodegenerative Diseases)H-Index: 6
Last. Alexander Dityatev (Otto-von-Guericke University Magdeburg)H-Index: 62
view all 6 authors...
Neural extracellular matrix (ECM) is a complex molecular meshwork surrounding neurons and glial cells in the extracellular space. Structural and functional state of ECM in the brain is tightly regulated by various components of neural ECM such as hyaluronic acid, chondroitin sulfate proteoglycans, link proteins, tenascins, various matrix-modifying enzymes such as chondroitin sulfate synthases and carbohydrate sulfotransferase together with matrix-degrading enzymes. Age-dependent accumulation of ...
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#1Eugenio F. Fornasiero (GAU: University of Göttingen)H-Index: 14
#2Sunit Mandad (GAU: University of Göttingen)H-Index: 8
Last. Silvio O. Rizzoli (GAU: University of Göttingen)H-Index: 49
view all 24 authors...
The turnover of brain proteins is critical for organism survival, and its perturbations are linked to pathology. Nevertheless, protein lifetimes have been difficult to obtain in vivo. They are readily measured in vitro by feeding cells with isotopically labeled amino acids, followed by mass spectrometry analyses. In vivo proteins are generated from at least two sources: labeled amino acids from the diet, and non-labeled amino acids from the degradation of pre-existing proteins. This renders meas...
70 CitationsSource
#1Huong Nguyen (GAU: University of Göttingen)H-Index: 4
#2Cemil Kerimoglu (GAU: University of Göttingen)H-Index: 15
Last. Tran Tuoc (GAU: University of Göttingen)H-Index: 16
view all 14 authors...
Summary During early cortical development, neural stem cells (NSCs) divide symmetrically to expand the progenitor pool, whereas, in later stages, NSCs divide asymmetrically to self-renew and produce other cell types. The timely switch from such proliferative to differentiative division critically determines progenitor and neuron numbers. However, the mechanisms that limit proliferative division in late cortical development are not fully understood. Here, we show that the BAF (mSWI/SNF) complexes...
20 CitationsSource
#1Cemil KerimogluH-Index: 15
#2M. Sadman Sakib (German Center for Neurodegenerative Diseases)H-Index: 6
Last. Andre Fischer (German Center for Neurodegenerative Diseases)H-Index: 49
view all 14 authors...
Summary Kmt2a and Kmt2b are H3K4 methyltransferases of the Set1/Trithorax class. We have recently shown the importance of Kmt2b for learning and memory. Here, we report that Kmt2a is also important in memory formation. We compare the decrease in H3K4 methylation and de-regulation of gene expression in hippocampal neurons of mice with knockdown of either Kmt2a or Kmt2b. Kmt2a and Kmt2b control largely distinct genomic regions and different molecular pathways linked to neuronal plasticity. Finally...
42 CitationsSource
#1M. Sadman Sakib (DU: University of Dhaka)H-Index: 6
#2Md. Rezaul Islam (GAU: University of Göttingen)H-Index: 6
Last. A.H.M. Nurun Nabi (DU: University of Dhaka)H-Index: 17
view all 4 authors...
This study aims to design epitope-based peptides for the utility of vaccine development by targeting glycoprotein G and envelope protein F of Nipah virus (NiV) that, respectively, facilitate attachment and fusion of NiV with host cells. Using various databases and tools, immune parameters of conserved sequence(s) from G and F proteins of different isolates of NiV were tested to predict probable epitope(s). Binding analyses of the peptides with MHC class-I and class-II molecules, epitope conserva...
28 CitationsSource