Fang-yuan Wang
Fourth Military Medical University
Cardiac function curveEndothelial stem cellInternal medicineEndocrinologyMolecular biologyEndoplasmic reticulumProinflammatory cytokineChemistryApoptosisImmunologySuperoxide dismutaseOxidative stressDiabetic cardiomyopathyInflammationGlutathione peroxidaseMacrophageFibrosisViability assayOvariectomized ratCell adhesion
Publications 2
#1Fang-yuan WangH-Index: 2
#2Jian JiaH-Index: 1
Last. Jing MaH-Index: 1
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Abstract Objective To investigate the protective effect and underlying mechanism(s) of icariin (ICA) in preventing hydrogen peroxide (H2O2)-induced vascular endothelial cell injury via endoplasmic reticulum stress (ERS). Methods To study the effects of ICA on H2O2-induced damage, we used the cell counting kit-8 assay to detect cell viability and the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay to determine cell adhesion and apoptosis, respectively. Spectrophotometr...
8 CitationsSource
#1Chengming Jia (Fourth Military Medical University)H-Index: 2
#2Hui Chen (Fourth Military Medical University)H-Index: 2
Last. Jing Ma (Fourth Military Medical University)H-Index: 3
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: Diabetic cardiomyopathy is a common disease in postmenopausal women, in whom the estrogen deficiency aggravates the pathology. In this study, we have found that estrogen deficiency due to ovariectomy aggravates the inflammation in the hearts of diabetic mice, as depicted by excessive proinflammatory type 1 macrophages (M1) over anti-inflammatory type 2 macrophages (M2). Accordingly, an additional increase of reactive oxygen species, cell apoptosis, cardiac hypertrophy, and fibrosis was observe...
25 CitationsSource