Mahesh Kumar Jerald
Centre for Cellular and Molecular Biology
Internal medicineDownregulation and upregulationEndocrinologySIRT3Proinflammatory cytokineGene knockdownTumor necrosis factor alphaChemistryHesperidinOxidative stressInflammationGalanginLactate dehydrogenaseFisetinInflammatory bowel diseaseSteviosideCytokineAnti-inflammatoryUlcerative colitisLipid peroxidationMedicinePharmacology
11Publications
5H-index
105Citations
Publications 12
Newest
#1Satya Krishna Tirunavalli (AcSIR: Academy of Scientific and Innovative Research)
#2Karthik Gourishetti (Indian Institute of Chemical Technology)H-Index: 7
Last. Sai Balaji Andugulapati (AcSIR: Academy of Scientific and Innovative Research)
view all 9 authors...
BACKGROUND: Inflammation-mediated lung injury is a major cause of health problems in many countries and has been the leading cause of morbidity/mortality in intensive care units. In the current COVID-19 pandemic, the majority of the patients experienced serious pneumonia resulting from inflammation (Acute respiratory distress syndrome/ARDS). Pathogenic infections cause cytokine release syndrome (CRS) by hyperactivation of immune cells, which in turn release excessive cytokines causing ARDS. Curr...
Source
#1Rajendra SangarajuH-Index: 3
#2Sateesh AlavalaH-Index: 6
Last. Ramakrishna Sistla (AcSIR: Academy of Scientific and Innovative Research)H-Index: 1
view all 5 authors...
1 CitationsSource
#1Sateesh Alavala (Indian Institute of Chemical Technology)H-Index: 6
#2Nasiruddin Nalban (Indian Institute of Chemical Technology)H-Index: 3
Last. Ramakrishna Sistla (Indian Institute of Chemical Technology)H-Index: 32
view all 7 authors...
Adjuvant arthritis is a chronic, autoimmune and inflammatory disorder of the joints. The occurrence of disorder causes a severe damage to the connective tissue eventually leading to progressive physical disability and eventual death. The recent years of evidence suggests the anti-inflammatory properties of stevioside, a diterpene glycoside. However, the effect of stevioside against adjuvant arthritis, a chronic inflammatory disorder is not known. Hence, the present study was designed to study th...
5 CitationsSource
#1Nasiruddin Nalban (Indian Institute of Chemical Technology)H-Index: 3
#2Rajendra Sangaraju (Indian Institute of Chemical Technology)H-Index: 3
Last. Ramakrishna Sistla (Indian Institute of Chemical Technology)H-Index: 32
view all 6 authors...
Arbutin is a glycoside reported for its anti-oxidant, anti-inflammatory and anti-tumor properties. However, the cardioprotective effect of Arbutin is not well established. The study aims to understand the effect of arbutin on isoproterenol (ISO)-induced cardiac hypertrophy in mice. The animals were pretreated with Arbutin for a week and ISO was administered for 10 days and then sacrificed. Cardiac injury markers such as creatinine kinase and lactate dehydrogenase concentrations were measured in ...
8 CitationsSource
#1Sateesh Alavala (Indian Institute of Chemical Technology)H-Index: 6
#2Rajendra Sangaraju (Indian Institute of Chemical Technology)H-Index: 3
Last. Ramakrishna Sistla (Indian Institute of Chemical Technology)H-Index: 32
view all 7 authors...
Abstract: Inflammatory bowel disease is an umbrella-term used to describe a set of chronic inflammatory conditions that affect the gastro-intestinal tract. Since most of the inflammatory medications in current use have several undesirable side-effects, stevioside, a naturally occurring, high-intensity sweetener was assessed in our study for its anti-inflammatory properties by in-vitro and in-vivo experiments. Stevioside was observed to significantly inhibit the levels of LPS induced elevation of...
15 CitationsSource
#1Rajendra Sangaraju (Indian Institute of Chemical Technology)H-Index: 3
#2Nasiruddin Nalban (Indian Institute of Chemical Technology)H-Index: 3
Last. Ramakrishna Sistla (Indian Institute of Chemical Technology)H-Index: 32
view all 6 authors...
Objective and design Inflammatory bowel disease (IBD) is known to cause chronic inflammation in the digestive tract by the immune malfunction. Herein, we demonstrate the protective effect of galangin (GAL), a phytochemical, on LPS-induced inflammation in cultured mouse macrophages (RAW 264.7) and the treatment of DSS-induced ulcerative colitis in Balb/c mice. However, the anti-inflammatory effect of GAL in DSS-exposed experimental colitis has not been investigated.
14 CitationsSource
#1Hemanth Kumar Boyina (Jawaharlal Nehru Technological University, Hyderabad)H-Index: 1
#2Mahesh Kumar Jerald (CCMB: Centre for Cellular and Molecular Biology)H-Index: 5
Last. Prakash V. DiwanH-Index: 43
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Abstract Hyperhomocysteinemia is a genetic disorder charecterized by elevated levels of homocysteine in the blood (> 15 μM). This study was aimed to evaluate the neuroprotective role of fisetin and hesperidin on homocysteine induced chronicmild hyperhomocysteinemia in wistar rats. DL-homocysteine (0.03 μmoL/g/ b.w,s.c.twice a day) administration from 30th–62nd postpartum day in rats induced chronic mild hyperhomocysteinemia. Rats were then evaluated for cognitive dysfunction, oxidative/nitrative...
4 CitationsSource
#1Prakash V. DiwanH-Index: 43
Last. Mahesh Kumar JeraldH-Index: 5
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Source
#1Salma Mukhtar Mir (AcSIR: Academy of Scientific and Innovative Research)H-Index: 2
#2Bidya Dhar Sahu (Indian Institute of Chemical Technology)H-Index: 16
Last. Ramakrishna Sistla (Indian Institute of Chemical Technology)H-Index: 32
view all 8 authors...
Dietary supplementation of oats has been associated with reduced risk of cardiovascular disease, diabetes, and gastrointestinal disorders. The role of oat extract as prophylactic in treating acute liver injury is not thoroughly established. We, therefore, hypothesized that oat extract would exert protective effect against alcohol-induced acute liver injury in a mouse model. To test this hypothesis, male C57BL/6 mice were pretreated with phenolic-enriched ethyl acetate (EA) fraction of oats (prep...
5 CitationsSource
#1Santosh Karnewar (AcSIR: Academy of Scientific and Innovative Research)H-Index: 11
#2Praveen Kumar Neeli (AcSIR: Academy of Scientific and Innovative Research)H-Index: 3
Last. Srigiridhar Kotamraju (Indian Institute of Chemical Technology)H-Index: 31
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Abstract Endothelial senescence in conjunction with mitochondrial dysfunction orchestrates age-associated cardiovascular disorders. In this study we investigated the causal link between these two processes and studied the molecular mechanisms by which metformin acts to coordinate the delay of endothelial senescence via enhancing mitochondrial biogenesis/function. AMPK activators metformin and AICAR delayed endothelial senescence via SIRT1-mediated upregulation of DOT1L, leading to increased trim...
48 CitationsSource