Yue Yu
Nanchang University
PolysaccharideCD3MonosaccharideCell wallOrganismFunction (biology)Molecular biologySulfationAntibodyProinflammatory cytokineCD8Tumor necrosis factor alphaKinaseChemistrySplenocyteIn vitroImmunologySuperoxide dismutaseIsolation (microbiology)ArabinoseOxidative stressSystemic inflammationCyclocaryaFlora (microbiology)MetaboliteAntioxidantGalactoseInflammatory bowel diseaseUronic acidGlutathione peroxidaseDioscoreaCarbohydrateImmunityVignaXylosePathogenesisDPPHMouse SpleenEpithelial DamageStarchy foodEnergy sourceHuman healthImmune homeostasisComplex ecosystemDisease occurrenceAntitumor activityHost immunityFood scienceSecretionp38 mitogen-activated protein kinasesNitric oxideBacteriaGut floraBiochemistryCarcinogenesisTraditional medicineMolecular massSignal transductionInterleukinBiologyImmune systemMicrobiologyMechanism (biology)Protein kinase APharmacologyMucilage
10Publications
6H-index
477Citations
Publications 10
Newest
#4Yue Yu (NCU: Nanchang University)H-Index: 6
Source
#1Qianqian Song (NCU: Nanchang University)H-Index: 8
#2Yikun Wang (NCU: Nanchang University)H-Index: 1
Last. Jianhua Xie (NCU: Nanchang University)H-Index: 35
view all 8 authors...
As a complex ecosystem of the human body, the intestinal flora maintains a dynamic balance with the host and plays an irreplaceable role in life activities such as nutritional metabolism and host immunity. The intestinal flora interacts with polysaccharides, the intestinal flora digests non-digestible polysaccharides, and polysaccharides can be used as an important energy source for intestinal microorganisms. Disturbance of the gut microbiota (GM) leads to the occurrence of diseases, polysacchar...
6 CitationsSource
#1Rong Huang (NCU: Nanchang University)H-Index: 2
#2Mingyue Shen (NCU: Nanchang University)H-Index: 29
Last. Jianhua Xie (NCU: Nanchang University)H-Index: 35
view all 5 authors...
Abstract A sulfated Chinese yam polysaccharide (S-CYP) was obtained from non-starch Chinese yam polysaccharide (CYP) by chlorosulfonic acid-pyridine (CSA-Pyr) method. The physicochemical characteristics and immunological activity of S-CYP were evaluated in this study. Results showed that sulfated modification changed the physicochemical properties of Chinese yam polysaccharide. Body weights and thymus index of the mice in polysaccharides group were increased compared with the cyclophosphamide (C...
3 CitationsSource
#1Rong Huang (NCU: Nanchang University)H-Index: 2
#2Jianhua Xie (NCU: Nanchang University)H-Index: 35
Last. Mingyue Shen (NCU: Nanchang University)H-Index: 29
view all 4 authors...
Abstract Yam (Dioscorea spp.), known as an edible and medicinal tuber crop in China, has been used historically for the treatment of diabetes, diarrhea, asthma, and other ailments in traditional Chinese medicine. Moreover, it has been consumed as starchy food for thousands of years in China. Modern phytochemistry and pharmacological experiments have been proved that non-starch polysaccharide is one of the main bioactive substances of yam. Many studies have been focused on the isolation and ident...
12 CitationsSource
#1Lixin Huang (NCU: Nanchang University)H-Index: 7
#2Mingyue Shen (NCU: Nanchang University)H-Index: 29
Last. Jianhua Xie (NCU: Nanchang University)H-Index: 35
view all 7 authors...
Abstract In this study, the immune responses of Mesona chinensis Benth polysaccharides (MP) in vitro and in vivo were investigated. Results showed that MP presented immunomodulatory activities on macrophages and T lymphocytes in vitro. Compared with the cyclophosphamide (Cy)-induced immunosuppressive mice, the body weights, spleen indexes (3.45 to 4.91) and thymus indexes (0.78 to 1.04) of the mice treated with MP were increased, and the peripheral blood levels were recovered. MP treatment also ...
6 CitationsSource
#1Yue Yu (NCU: Nanchang University)H-Index: 6
#2Qianqian Song (NCU: Nanchang University)H-Index: 8
Last. Jianhua Xie (NCU: Nanchang University)H-Index: 35
view all 7 authors...
Abstract Two sulfated polysaccharides SCP3 and SCP5 with degree of substitution (DS) 0.45 and 0.13 were obtained by modifying the Cyclocarya paliurus polysaccharide (CP) with chlorosulfonic acid-pyridine method. Results demonstrated that the physicochemical properties, molar ratios of monosaccharide composition, molecular weights, and in vitro immunomodulatory activity were changed after being sulfated. Splenocytes proliferation assay showed that both CP and sulfated polysaccharides have immunom...
11 CitationsSource
#1Qianqian Song (NCU: Nanchang University)H-Index: 8
#2Lian Jiang (NCU: Nanchang University)H-Index: 11
Last. Jianhua Xie (NCU: Nanchang University)H-Index: 35
view all 8 authors...
Abstract A water-soluble polysaccharide (MBP-1) was isolated from Mung bean (Vigna radiate L.) and its physicochemical characterization, functional properties, and antioxidant activity was investigated. Chemical analysis revealed that the contents of carbohydrate, uronic acid, and protein were 33.05 ± 0.10%, 25.83 ± 0.04%, and 3.17 ± 0.36%, respectively. The molecular weight (Mw) of MBP-1 was 146.22 kDa and it was consist of arabinose (Ara), glucose (Glc), xylose (Xyl), galactose (Gal), and gala...
8 CitationsSource
#1Liqiao Liu (NCU: Nanchang University)H-Index: 2
#2Mingzhu Li (NCU: Nanchang University)H-Index: 1
Last. Jianhua Xie (NCU: Nanchang University)H-Index: 35
view all 7 authors...
Abstract Natural polysaccharides, the abundant dietary components, show potent antitumor bioactivity in treatment and chemoprevention. Compared with traditional tumor therapy, natural polysaccharides are characterized by the low toxicity and immuno-regulation function. Recent researches have indicated that the anti-tumor of polysaccharides was partly attributable to modification in the composition of gut microbiota when polysaccharides were digested. Indeed, microbial dysbiosis or alteration of ...
52 CitationsSource
#1Yue Yu (NCU: Nanchang University)H-Index: 6
#2Mingyue Shen (NCU: Nanchang University)H-Index: 29
Last. Jianhua Xie (NCU: Nanchang University)H-Index: 35
view all 4 authors...
Abstract Pharmacotherapy using natural substances can be currently regarded as a very promising future alternative to conventional therapy. As biological macromolecules, polysaccharide together with protein and polynucleotide, are extremely important biomacromoleules which play important roles in the growth and development of living organism. Polysaccharide is important component of higher plants, membrane of the animal cell and the cell wall of microbes. It is also closely related to the physio...
320 CitationsSource
#1Yue Yu (NCU: Nanchang University)H-Index: 6
#1Yue Yu (NCU: Nanchang University)H-Index: 1
Last. Jianhua Xie (NCU: Nanchang University)H-Index: 35
view all 6 authors...
Abstract In this study, a sulfated polysaccharide (S-CP 1-8 ) was obtained from Cyclocarya paliurus by chlorosulfonic acid-pyridine method. S-CP 1-8 was chemical characterized and cultured with macrophage RAW264.7 cells to evaluate its immunomodulatory activity. Preliminary physicochemical analysis identified arabinose (Ara), galactose (Gal) and glucose (Glc) were the major monosaccharides of S-CP 1-8 , with average Molecular weight ( Mw ) of 970 kDa and contained sulfate with degree of substitu...
76 CitationsSource