Geertje M. de Boer
Erasmus University Rotterdam
Self-efficacyInternal medicineSurgeryRandomized controlled trialPhysical therapyPediatricsMedical recordCohort studyImmunologyPlaceboAsthmaCOPDExacerbationDiseaseIntegrated carePopulationAsthma exacerbationsPatient Activation MeasureAnxietyMedicineCohort
Publications 18
#1Geertje M. de Boer (EUR: Erasmus University Rotterdam)H-Index: 5
Last. Rudi W. Hendriks (EUR: Erasmus University Rotterdam)H-Index: 55
view all 11 authors...
Abstract null null Introduction null Adult-onset asthma (AOA) is usually more severe compared to childhood onset asthma (CoA). Given the increasing evidence that AoA is associated with obesity, we investigated the relationship of other related metabolic comorbid conditions with AoA compared to CoA. null null null Study design and methods null This cross-sectional study compared the metabolic syndrome and lipid derived inflammatory markers in patients with AoA, CoA and age- and sex-matched contro...
#1Geertje M. de Boer (EUR: Erasmus University Rotterdam)H-Index: 5
#2Gert-Jan Braunstahl (Erasmus University Medical Center)H-Index: 25
Last. Bianca M Boxma-de KlerkH-Index: 1
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BACKGROUND Asthma exacerbations are frequently induced by respiratory tract infections (RTIs). Bacterial lysates have been described to possess immune-modulatory effects and reduce RTIs as well as asthma symptoms in children. However, whether bacterial lysates have similar effects in adult asthma patients is unknown. AIMS To reduce asthma exacerbations by add-on bacterial lysate therapy in adults with severe asthma and to characterize the clinical and immune-modulatory effects of this treatment....
#1Geertje M. de Boer (EUR: Erasmus University Rotterdam)H-Index: 5
#2Laura HouwelingH-Index: 2
Last. Gert-Jan Braunstahl (EUR: Erasmus University Rotterdam)H-Index: 25
view all 6 authors...
Population studies showed a decrease in psychological wellbeing during the COVID-19 pandemic. Asthma is associated with a negative effect on anxiety and depression, which might worsen during the COVID-19 lockdown. The aim of the study was to compare fear, anxiety and depression between asthma patients and patients wit hout asthma pre-COVID-19 and during COVID-19 pandemic.This study compares fear, anxiety and depression in asthma patients and controls between pre-COVID-19 and during COVID-19 lock...
Background: Adults with a high body mass index (BMI) have an increased risk of developing asthma. To explore the impact of increased lipids on the presence of asthma, this study investigated the relationship between lipid levels and inflammatory markers in patients with asthma and controls with obesity. Objective: We hypothesized that higher lipid levels are more prevalent in patients with obesity and asthma. Methods: In this explorative cohort study, 96 patients with asthma and 45 controls were...
#1Geertje M. de Boer (EUR: Erasmus University Rotterdam)H-Index: 5
#2Gert-Jan Braunstahl (EUR: Erasmus University Rotterdam)H-Index: 25
view all 4 authors...
INTRODUCTION Following the recent COVID-19 lockdown, a reduction in emergency healthcare visits was reported. Infectious diseases were less often diagnosed, while it was not clear if this was due to a decrease in prevalence or a decrease in emergency healthcare visits due to fear of COVID-19. METHODS This study comprises a follow-up from a recently finished randomised controlled trial, to gain insight into the prevalence of asthma exacerbation and fear of COVID-19 in patients with moderate-sever...
#1Esmee K. van der Ploeg (EUR: Erasmus University Rotterdam)H-Index: 4
#2Korneliusz Golebski (UvA: University of Amsterdam)H-Index: 13
Last. Suzanne M. Bal (UvA: University of Amsterdam)H-Index: 28
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Group 2 innate lymphoid cells (ILC2s) orchestrate protective type 2 immunity and have been implicated in various immune disorders. In the mouse, circulatory inflammatory ILC2s (iILC2s) were identified as a major source of type 2 cytokines. The human equivalent of the iILC2 subset remains unknown. Here, we identify a human inflammatory ILC2 population that resides in inflamed mucosal tissue and is specifically marked by surface CD45RO expression. CD45RO+ ILC2s are derived from resting CD45RA+ ILC...
#1Geertje M. de Boer (EUR: Erasmus University Rotterdam)H-Index: 5
#2Jakub Żółkiewicz (Medical University of Warsaw)H-Index: 3
Last. Gerdien A. Tramper-Stranders (EUR: Erasmus University Rotterdam)H-Index: 15
view all 8 authors...
Wheezing and asthma are a growing cause of morbidity in children and adults. Treatment is aimed at prevention of disease exacerbations and preservation of lung function. Respiratory viruses are involved in ∼40–60% of exacerbations. Bacterial lysates prevent recurrent respiratory tract infections and might reduce exacerbations. Moreover, immunomodulatory effects have been observed in human and animal studies. Here we aimed to assess the effects of bacterial lysate therapy on preschool wheezing ep...
#1Geertje M. de BoerH-Index: 5
#2Gert-Jan BraunstahlH-Index: 25
Last. Gerdien TramperH-Index: 1
view all 4 authors...
Decrease in asthma exacerbation prevalence during the Covid-19 lockdown in a moderate-severe asthma cohortTo the editor,Following the recent Covid-19 lockdown, in Canada a reduction in emergency healthcare visits was reported (1). Infectious diseases were less often diagnosed, probably due to social distancing and increased hygiene measures. However, also fear of acquiring Covid-19 infection at medical facilities might have led to a decrease in visits (1, 2).Recent studies indicated that control...
#1Heleen Vroman (EUR: Erasmus University Rotterdam)H-Index: 13
#2Irma Tindemans (EUR: Erasmus University Rotterdam)H-Index: 7
Last. Mirjam Kool (EUR: Erasmus University Rotterdam)H-Index: 34
view all 9 authors...
In the last decades it has become clear that dendritic cells (DCs) critically contribute to the development of T helper 2 (Th2)-mediated allergic diseases, such as asthma. Two main conventional DC (cDC) subsets, type 1 cDCs (cDC1s) and cDC2s, can be identified based on the expression of cell-surface molecules and transcription factors [1]. Using mouse models in which specific DC subsets are targeted or by adoptive transfer of DC subsets, it has been shown that upon activation in the airways cDC2...
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