Y. Liang
University of California, San Diego
AlgorithmCancerInternal medicineRadiologyMagnetic resonance imagingImage registrationStandardized uptake valueCervical cancerChemoradiotherapyWhite blood cellAnal cancerBone marrowIntensity-modulated radiation therapyTotal Marrow IrradiationNuclear medicineVolumetric modulated arc therapyMedical imagingComputer scienceRadiation therapyMedicineDosimetry
23Publications
8H-index
706Citations
Publications 22
Newest
#1J. Pritz (UCSD: University of California, San Diego)H-Index: 4
#2Sachin Gulaya (UCSD: University of California, San Diego)H-Index: 6
Last. Graeme M. Bydder (UCSD: University of California, San Diego)H-Index: 92
view all 12 authors...
Purpose: To test the hypothesis that pelvic bone marrow fat fraction (FF) (i.e., quantity of fat relative to water) varies with glucose metabolism and radiation dose in patients undergoing pelvic radiotherapy. Methods: 34 patients with pelvic malignancies were enrolled from 2009‐2012 on prospective trials; 31 received concurrent chemotherapy. All patients underwent baseline 18F‐FDG‐PET and quantitative MRI with IDEAL‐IQ. 9 patients underwent PET/CT simulation, 15 PET/CT, and 10 PET‐only. 18 and ...
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#1Y. Liang (UCSD: University of California, San Diego)H-Index: 8
#2Gwe-Ya Kim (UCSD: University of California, San Diego)H-Index: 14
Last. Loren K. Mell (UCSD: University of California, San Diego)H-Index: 52
view all 5 authors...
The purpose of this study was to develop dosimetry verification procedures for volumetric-modulated arc therapy (VMAT)-based total marrow irradiation (TMI). The VMAT based TMI plans were generated for three patients: one child and two adults. The planning target volume (PTV) was defined as bony skeleton, from head to mid-femur, with a 3 mm margin. The plan strategy similar to published studies was adopted. The PTV was divided into head and neck, chest, and pelvic regions, with separate plans eac...
10 CitationsSource
#1Y. Liang (UCSD: University of California, San Diego)H-Index: 8
#2Mark Bydder (UCSD: University of California, San Diego)H-Index: 31
Last. Loren K. Mell (UCSD: University of California, San Diego)H-Index: 52
view all 13 authors...
Purpose To test the hypothesis that intensity modulated radiation therapy (IMRT) can reduce radiation dose to functional bone marrow (BM) in patients with pelvic malignancies (phase IA) and estimate the clinical feasibility and acute toxicity associated with this technique (phase IB). Methods and Materials We enrolled 31 subjects (19 with gynecologic cancer and 12 with anal cancer) in an institutional review board-approved prospective trial (6 in the pilot study, 10 in phase IA, and 15 in phase ...
75 CitationsSource
#1Brent S. Rose (UCSD: University of California, San Diego)H-Index: 19
#2Y. Liang (UCSD: University of California, San Diego)H-Index: 8
Last. Loren K. Mell (UCSD: University of California, San Diego)H-Index: 52
view all 7 authors...
Purpose To test the hypothesis that radiation dose to 18 F-fluorodeoxyglucose positron emission tomography ( 18 F-FDG-PET)-defined active bone marrow (BM ACT ) subregions is correlated with hematologic toxicity in cervical cancer patients treated with chemoradiotherapy. Methods and Materials The conditions of 26 women with cervical cancer who underwent 18 F-FDG-PET before treatment with concurrent cisplatin and intensity-modulated radiation therapy were analyzed. BM ACT was defined as the subreg...
67 CitationsSource
#1Y. Liang (UCSD: University of California, San Diego)H-Index: 8
#2Gwe-Ya Kim (UCSD: University of California, San Diego)H-Index: 14
Last. Todd Pawlicki (UCSD: University of California, San Diego)H-Index: 36
view all 6 authors...
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#1Y. Liang (UCSD: University of California, San Diego)H-Index: 8
#2Loren K. Mell (UCSD: University of California, San Diego)H-Index: 52
Last. G Kim (UCSD: University of California, San Diego)H-Index: 3
view all 3 authors...
Purpose: This study develops treatment planning and a comprehensive dosimetry verification procedure for volumetric modulated arc therapy(VMAT) based total marrow irradiation(TMI), a form of targeted total body irradiation(TBI). Methods: The simulation CT of 3 patients treated with TBI were used. Planning was done with Eclipse treatment planning system(Varian Medical Systems, CA). Planning volume(PTV) was defined as skeletal bone, rib, and sternum, with 3mm margin, from head to mid‐femur. In tot...
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#1Y. Liang (UCSD: University of California, San Diego)H-Index: 8
#2Mark Bydder (UCSD: University of California, San Diego)H-Index: 31
Last. Loren K. Mell (UCSD: University of California, San Diego)H-Index: 52
view all 10 authors...
1 CitationsSource
#1Y. Liang (UCSD: University of California, San Diego)H-Index: 8
#2Karen Messer (UCSD: University of California, San Diego)H-Index: 56
Last. Loren K. Mell (UCSD: University of California, San Diego)H-Index: 52
view all 8 authors...
Purpose To study the effects of increasing pelvic bone marrow (BM) radiation dose on acute hematologic toxicity in patients undergoing chemoradiotherapy, using a novel modeling approach to preserve the local spatial dose information. Methods and Materials The study included 37 cervical cancer patients treated with concurrent weekly cisplatin and pelvic radiation therapy. The white blood cell count nadir during treatment was used as the indicator for acute hematologic toxicity. Pelvic BM radiatio...
31 CitationsSource
#1William Y. Song (UCSD: University of California, San Diego)H-Index: 21
#2S Huh (UF: University of Florida)H-Index: 11
Last. Loren K. Mell (UCSD: University of California, San Diego)H-Index: 52
view all 8 authors...
The objective was to compare intensity-modulated radiation therapy (IMRT) with 3D conformal proton therapy (3DCPT) in the treatment of cervical cancer. In particular, each technique's ability to spare pelvic bone marrow (PBM) was of primary interest in this study. A total of six cervical cancer patients (3 postoperative and 3 intact) were planned and analyzed. All plans had uniform 1.0 cm CTV-PTV margin and satisfied the 95% PTV with 100% isodose (prescription dose = 45 Gy) coverage. Dose-volume...
25 CitationsSource
#1Y. Liang (UCSD: University of California, San Diego)H-Index: 8
Purpose: To quantify changes in pelvic bone marrow (BM) fat fraction (FF) during concurrent chemoradiotherapy for patients with pelvic malignancies.Method and Materials: The study includes 6 patients with stage I–III cervical cancer and 4 patients with stage II–III anal cancer. For cervical cancer patients, treatment consisted of IMRT, 45 Gy in 1.8 Gy daily fractions with concurrent weekly cisplatin, followed by intracavitary brachytherapy boost. For anal cancer patients, treatment consisted of ...
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