F Damm
Internal medicineEndocrinologyPeripheral blood mononuclear cellAlkaline phosphataseInterleukin 10ImmunologySystemic lupus erythematosusRheumatoid arthritisAutoimmune diseaseMonocyteMedicineInterleukin
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Inherited C1q deficiency is associated strongly with the development of systemic lupus erythematosus (SLE). The aim of our study was to evaluate the ability of monocytes from SLE patients without inherited C1q deficiency to up-regulate C1q-mRNA upon stimulation. Furthermore, we wanted to elucidate the physiological stimulus for up-regulation of C1q-mRNA. Peripheral blood mononuclear cell (PBMC)-derived monocytes from 10 SLE patients, 10 patients with rheumatoid arthritis (RA) and 10 healthy cont...
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