Song-Lin Li
Nanjing University of Chinese Medicine
AnalytePharmacokineticsAnalytical chemistryMass spectrometryHigh-performance liquid chromatographyChemistryDecoctionRadixMetabolomicsGinsenosideGinsengFumigationChemical markerTandem mass spectrometryChromatographySulfurGut floraTraditional medicineMedicinePharmacology
98Publications
26H-index
2,407Citations
Publications 78
Newest
#1Shan-Shan ZhouH-Index: 10
#2Jing ZhouH-Index: 3
Last. Song-Lin LiH-Index: 26
view all 11 authors...
The therapeutic effects of water extract of ginseng (WEG) on exercise-induced fatigue (EF) have been reported in several previous studies, but the molecular mechanisms involved remain unexplored. In this study, the anti-EF effects of WEG were studied, and the potential mechanisms were discussed. We characterized the chemical components of WEG by ultra-high performance liquid chromatography-tandem triple quadrupole mass spectrometry (UHPLC-QqQ-MS/MS) and high performance liquid chromatography cou...
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#1Ying Yang (UM: University of Macau)H-Index: 2
#2Nan Hu (UM: University of Macau)H-Index: 7
Last. Ru Yan (UM: University of Macau)H-Index: 25
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Abstract Ethnopharmacological relevance Application of cyclosporine A (CsA) as a rescue treatment in acute severe ulcerative colitis (UC) is limited by its narrow therapeutic window and great interpatient variability. As a substrate of cytochrome P450 3A enzyme (CYP3A) and P-glycoprotein (P-gp), the oral pharmacokinetics of CsA is susceptible to disease status and concomitant medications. Combined treatment with ginseng, a famous medicinal herb frequently prescribed for ameliorating abnormal imm...
2 CitationsSource
#1Jin-Hao Zhu (Nanjing University of Chinese Medicine)
#1Jin-Hao Zhu (Nanjing University of Chinese Medicine)
Last. Song-Lin Li (Nanjing University of Chinese Medicine)H-Index: 26
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Ginseng is usually consumed as a dietary supplement for health care in the normal state or prescribed as a herbal medicine in pathologic conditions. Although metabolic studies of ginseng are commonly performed on healthy organisms, the metabolic characteristics in pathologic organisms remain unexplored. This study aimed to uncover the difference in intestinal metabolism of ginseng between normal and cyclophosphamide-induced immunosuppressed rats and further discuss the potential mechanisms invol...
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#1Cheng-Ying Wu (Nanjing University of Chinese Medicine)H-Index: 5
#2Jing Zhou (Peking Union Medical College)H-Index: 3
Last. Song-Lin Li (Nanjing University of Chinese Medicine)H-Index: 26
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In the present study, the hypoglycemic effects of glucomannan (AGM) and its enzyme-degraded products from Amorphophallus albus were investigated. Four degraded products were prepared through ultrafiltration of β-glucanase-degraded products of AGM. The hypoglycemic activities were evaluated in HFD-STZ-induced type 2 diabetes mellitus (T2DM) mice, and the diversity of gut bacteria was analyzed by 16S rRNA gene sequencing; the fecal short chain fatty acids (SCFAs) and endogenous metabolites were de...
1 CitationsSource
#1Fei Xu (Nanjing University of Chinese Medicine)
#2Ming Kong (Nanjing University of Chinese Medicine)H-Index: 11
Last. Song-Lin Li (Nanjing University of Chinese Medicine)H-Index: 26
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Abstract Sulfur fumigation and heating desulfurization are used together in the post-harvest processing of many medicinal herbs. However, little is known about the effects of sulfur fumigation on saccharide components, nor about the effects of heating desulfurization on all herbal constituents. In this study, metabolomics and glycomics were integrated to investigate the effects of these two processes on the chemistry of Codonopsis Radix (CR) as a pilot study. The results showed that both sulfur ...
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#1Shan-Shan Zhou (Hong Kong Baptist University)H-Index: 10
#2Kathy Ka-Wai Auyeung (Hong Kong Baptist University)H-Index: 17
Last. Song-Lin Li (Nanjing University of Chinese Medicine)H-Index: 26
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Abstract Background Ginseng has therapeutic potential for treating obesity and the associated gut microbiota dysbiosis. However, whether white ginseng and red ginseng, the two kinds of commonly used processed ginseng, possess different anti-obesity effects remains unknown. Purpose Anti-obesity effects of water extracts of white ginseng and red ginseng (WEWG and WERG) were compared, and the potential mechanisms were discussed. Methods Chemical profiles of WEWG and WERG were characterized by ultra...
11 CitationsSource
#1Chun-Feng QiaoH-Index: 27
#2Zhen-Dan HeH-Index: 15
Last. Pang-Chui ShawH-Index: 55
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In 2005 edition of the Chinese Pharmacopoeia, lobetyolin was used as a marker for TLC identification of Radix Codonopsis, whose source plants are Codonopsis pilosula, C. pilosula var. modesta and C. tangshen. Quantification of lobetyolin in 44 samples derived from eight species of Codonopsis and another four genera of the same family Campanulaceae revealed that lobetyolin is present in all Codonopsis species and in Campanumoea javanica, Platycodon grandiflorum and Lobelia chinensis. In fact, the...
20 CitationsSource
#1Hong Shen (Nanjing University of Chinese Medicine)H-Index: 14
#2Li Zhang (Nanjing University of Chinese Medicine)H-Index: 22
Last. Song-Lin Li (Nanjing University of Chinese Medicine)H-Index: 26
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Abstract Ethnopharmacological relevance Sulfur-fumigation has been developed to prevent insects and molds during post-harvest handling of Panax ginseng C.A. Mey (ginseng) in the near decades. Our previous study indicated sulfur-fumigation could transform ginsenosides, the active components of ginseng, into sulfur-containing derivatives (SFCDs), the artifacts with unknown toxicity. However, whether the biotransformation could be occurred and absorption characteristics between ginsenosides and SFC...
4 CitationsSource
#1Jin Di Xu (Nanjing University of Chinese Medicine)H-Index: 1
#1Jin-Di Xu (Nanjing University of Chinese Medicine)H-Index: 11
Last. Song-Lin Li (Nanjing University of Chinese Medicine)H-Index: 26
view all 11 authors...
Abstract High performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (HPLC-QTOF-MS) is widely used to qualitatively characterize the chemical profiles of herbal medicines, in which the generated adducts and fragments are crucial for confirming molecular ion (deprotonated/protonated ion) and deducing structure of detected components. However, how chromatographic and mass spectrometric (LC–MS) conditions/parameters affect the quantity and intensity of adducts an...
1 CitationsSource
#1Li Zhou (Nanjing University of Chinese Medicine)H-Index: 4
#2Jin-Di Xu (Hong Kong Baptist University)H-Index: 11
Last. Song-Lin Li (Nanjing University of Chinese Medicine)H-Index: 26
view all 10 authors...
Abstract In metabolomics studies, metabolic pathway recognition (MPR) is performed by software tools to screen out the significant pathways disturbed by diseases or reinstated by drugs. To achieve MPR, the significantly changed metabolites determined in different biospecimens ( e.g. plasma and urine) are analyzed either independently (metabolites from each biospecimen as a dataset) or integratively (metabolites from all biospecimens as a dataset). However, whether the choice of these two process...
2 CitationsSource