Bin Yu
Southern Medical University
EndocrinologySurgeryPathologyRandomized controlled trialBone remodelingChemistryMesenchymal stem cellIn vivoOsteoarthritisOsteoblastAnkleStaphylococcus aureusOsteomyelitisBone regenerationCalciumOrthopedic surgeryMedicineBiologyMeta-analysisCell biology
142Publications
18H-index
1,153Citations
Publications 154
Newest
#1Huajun Zheng (Southern Medical University)
#2Weicheng Zhai (Southern Medical University)
Last. Pingzhen Yang (Southern Medical University)H-Index: 6
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Vascular remodeling and restenosis are common complications after percutaneous coronary intervention. Excessive proliferation and migration of vascular smooth muscle cells (VSMCs) play important roles in intimal hyperplasia-induced vascular restenosis. NK2 Homeobox 3 (Nkx2-3), a critical member of Nkx family, is involved in tissue differentiation and organ development. However, the role of Nkx2-3 in VSMCs proliferation and migration remains unknown. In this study, we used carotid balloon injury ...
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#1Xiaonan Liu (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 3
#2Yu Chai (Southern Medical University)H-Index: 5
Last. Mei Wan (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 32
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Synthetic glucocorticoids (GCs), one of the most effective treatments for chronic inflammatory and autoimmune conditions in children, have adverse effects on the growing skeleton. GCs inhibit angiogenesis in growing bone, but the underlying mechanisms remain unclear. Here, we show that GC treatment in young mice induces vascular endothelial cell senescence in metaphysis of long bone, and that inhibition of endothelial cell senescence improves GC-impaired bone angiogenesis with coupled osteogenes...
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#1Jun Yang (Southern Medical University)H-Index: 73
#2Hanjun Qin (Southern Medical University)H-Index: 3
Last. Bin Yu (Southern Medical University)H-Index: 18
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Abstract Objective The antibacterial activity of copper (Cu)-alloy biomaterials has shown a great potential in clinical application. Here, we evaluated the osteogenesis and antibacterial effects of Ti6Al4V-6.5wt%Cu alloy in an in vivo model of infected bone defects and determine their responsible proteins and pathways using proteomics. Methods After bone defects were filled with Ti6Al4V and Ti6Al4V-6.5wt%Cu implants for 6 week, the tissue and bone samples around the implants were harvested for r...
1 CitationsSource
#1Peisheng Chen (Fujian Medical University)H-Index: 4
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BACKGROUND Osteomyelitis is a difficult problem for orthopedic surgeons due to its great harm and complicated treatment. In this study, we aim to make a bibliometric analysis of the literature related to osteomyelitis and explore the research status, hotspots and frontiers in this field in recent 10 years. METHODS Literature relating to osteomyelitis from 2010 to 2019 was retrieved from the database of Science Citation Index Expanded (SCIE) of Web of Science. CiteSpace was used to analyze countr...
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#1Yihuang Lin (Southern Medical University)H-Index: 1
#2Jianwen Su (Southern Medical University)H-Index: 2
Last. Bin Yu (Southern Medical University)H-Index: 18
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To investigate the molecular pathogenesis of bone with osteomyelitis, we developed implant-associated osteomyelitis (IAOM) models in mice. An orthopedic stainless pin was surgically placed in the right femoral mid-shaft of mice followed by an inoculation of S. aureus into the medullary cavity. Typical characteristics of IAOM, like periosteal reaction and intra-osseous abscess, occurred by day 14 post-infection. By day 28 post-infection, necrotic abscess, sequestrum formation and deformity of the...
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#1Lei Huang (Southern Medical University)H-Index: 2
#2Yong Heng Xie (Southern Medical University)
Last. Bin Yu (Southern Medical University)H-Index: 18
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Bone cements were prepared by mixing calcium sulfate and copper sulfate in various proportions. We examined physical and physicochemical properties of the copper doped calcium sulfates and the effe...
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#1Nan Jiang (Southern Medical University)H-Index: 5
#1Nan Jiang (Southern Medical University)H-Index: 11
Last. Bin Yu (Southern Medical University)H-Index: 18
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#1Daorong Xu (Southern Medical University)
#2Jikun Qian (Southern Medical University)H-Index: 1
Last. Bin Yu (Southern Medical University)H-Index: 18
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In the mammalian skeletal system, osteogenesis and angiogenesis are closely linked by type H vessels during bone regeneration and repair. Our previous studies confirmed the promotion of these processes by copper-containing metal (CCM) in vitro and in vivo. However, whether and how the coupling of angiogenesis and osteogenesis participates in the promotion of bone regeneration by CCM in vivo is unknown. In this study, M2a macrophages but not M2c macrophages were shown to be immunoregulated by CCM...
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#1Nan Jiang (Southern Medical University)H-Index: 11
#2Bin Yu (Southern Medical University)H-Index: 18
1 CitationsSource