Deyun Chen
Chinese PLA General Hospital
DNA repairCellular differentiationCellRegeneration (biology)ChemistrySkin repairMesenchymal stem cellImmunologyT cellImmunotherapyDecitabineWound healingAngiogenesisHair follicle morphogenesisChimeric antigen receptorCancer researchMedicineReprogrammingBiologyCell biology
Publications 14
#1Dongdong Ti (Chinese PLA General Hospital)H-Index: 16
#2Miaomiao Bai (Chinese PLA General Hospital)H-Index: 5
Last. Weidong Han (Chinese PLA General Hospital)H-Index: 50
view all 8 authors...
Impaired tumor-specific effector T cells contribute to tumor progression and unfavorable clinical outcomes. As a compensatory T cell-dependent cancer immunoediting strategy, adoptive T cell therapy (ACT) has achieved encouraging therapeutic results, and this strategy is now on the center stage of cancer treatment and research. ACT involves the ex vivo stimulation and expansion of tumor-infiltrating lymphocytes (TILs) with inherent tumor reactivity or T cells that have been genetically modified t...
1 CitationsSource
#1Yao WangH-Index: 24
#2Chuan TongH-Index: 19
Last. Weidong Han (Yahoo!)H-Index: 50
view all 16 authors...
Insufficient eradication capacity and dysfunction are common occurrences in T cells that characterize cancer immunotherapy failure. De novo DNA methylation promotes T cell exhaustion, whereas methylation inhibition enhances T cell rejuvenation in vivo. Decitabine, a DNA methyltransferase inhibitor approved for clinical use, may provide a means of modifying exhaustion-associated DNA methylation programmes. Herein, anti-tumour activities, cytokine production, and proliferation are enhanced in deci...
2 CitationsSource
#1Miaomiao BaiH-Index: 5
#2Dongdong TiH-Index: 16
Last. Weidong HanH-Index: 50
view all 9 authors...
The human body is a complex structure of cells, which are exposed to many types of stress. Cells must utilize various mechanisms to protect their DNA from damage caused by metabolic and external sources to maintain genomic integrity and homeostasis and to prevent the development of cancer. DNA damage inevitably occurs regardless of physiological or abnormal conditions. In response to DNA damage, signaling pathways are activated to repair the damaged DNA or to induce cell apoptosis. During the pr...
#1Xin YanH-Index: 1
#2Yongtian ZhaoH-Index: 1
Last. Weidong Han (NKU: Nankai University)H-Index: 50
view all 12 authors...
Background: Although the programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors have markedly changed the strategies of cancer treatment, most patients with advanced non-small cell lung cancer (NSCLC) do not respond to PD-1/PD-L1 monotherapy. Epigenetic drugs have been hypothesized to possess the potential to sensitize PD-1/PD-L1 inhibitors. Case Presentation: Three patients with advanced metastatic NSCLC failed to respond to first-line systemic therapy and had a low tumor mutati...
#1Yuan Jifang (Chinese PLA General Hospital)H-Index: 1
#2Qian Hou (Chinese PLA General Hospital)H-Index: 10
Last. Xiaobing Fu (Chinese PLA General Hospital)H-Index: 22
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Small molecules loaded into biological materials present a promising strategy for stimulating endogenous repair mechanisms for in situ skin regeneration. Lithium can modulate various biologic processes, promoting proliferation, angiogenesis, and decreasing inflammation. However, its role in skin repair is rarely reported. In this study, we loaded lithium chloride (LiCl) into the chitosan (CHI) hydrogel and develop a sterile and biocompatible sponge scaffold through freeze-drying. In-vitro assess...
5 CitationsSource
#1Deyun Chen (Chinese PLA General Hospital)H-Index: 8
#2Qian Hou (Chinese PLA General Hospital)H-Index: 10
Last. Xiaobing Fu (Chinese PLA General Hospital)H-Index: 22
view all 6 authors...
Skin regeneration is a vexing problem in the field of regenerative medicine. A bioactive molecule-based strategy has been frequently used in skin wound healing in recent years. Bioactive molecules are practical tools for regulating cellular processes and have been applied to control cellular differentiation, dedifferentiation, and reprogramming. In this review, we focus on recent progress in the use of bioactive molecules in skin regenerative medicine, by which desired cell types can be generate...
3 CitationsSource
#1Zhitao Gao (Chinese PLA General Hospital)H-Index: 1
#2Chuan Tong (Chinese PLA General Hospital)H-Index: 19
Last. Weidong Han (Chinese PLA General Hospital)H-Index: 50
view all 6 authors...
Abstract Chimeric antigen receptor T-cell (CAR T) therapy is a kind of effective cancer immunotherapy. However, designing CARs remains a challenge because many targetable antigens are shared by T cells and tumor cells. This shared expression of antigens can cause CAR T cell fratricide. CD38-targeting approaches (e.g., daratumumab) have been used in clinical therapy and have shown promising results. CD38 is a kind of surface glycoprotein present in a variety of cells, such as T lymphocytes and tu...
9 CitationsSource
#1Lingzhi Zhong (Chinese PLA General Hospital)H-Index: 3
#2Haojie Hao (Chinese PLA General Hospital)H-Index: 23
Last. Xiaobing Fu (Chinese PLA General Hospital)H-Index: 29
view all 10 authors...
BACKGROUND: Tissue contraction and the extracellular matrix deposition are part of the pathogenesis of hypertrophic scars. The transcriptional factor NFE2L2 inhibits fibroblast differentiation in idiopathic pulmonary fibrosis and promotes myofibroblast dedifferentiation. Our previous study showed that the transcription factor NFE2L2 was strongly induced on treatment with arsenic trioxide (ATO). OBJECTIVE: The present study sought to investigate the effect of ATO on myofibroblast formation to det...
9 CitationsSource
#1Hong Huang (NKU: Nankai University)H-Index: 2
#1Hong Huang (NKU: Nankai University)H-Index: 36
Last. Weidong Han (Chinese PLA General Hospital)H-Index: 50
view all 11 authors...
Volumetric muscle loss (VML) injury resulted from massive muscle defects and diseases for which there are still no effective therapeutic treatments. This study aimed to investigate the effects of rat adipose-derived mesenchymal stem cells (rASCs) and rASCs-conditioned medium- (CM-) based type I collagen hydrogel on macrophage (MP) transition, myogenesis, and vascularization in the rat VML model. Laser Doppler results demonstrated much higher blood flow in the rASC- and CM-based hydrogel groups. ...
11 CitationsSource
#1Liang Dong (Chinese PLA General Hospital)H-Index: 15
#2Haojie Hao (Chinese PLA General Hospital)H-Index: 23
Last. Weidong Han (Chinese PLA General Hospital)H-Index: 50
view all 11 authors...
Hair follicle morphogenesis and regeneration depend on intensive but well-orchestrated interactions between epithelial and mesenchymal components. Therefore, an alternative strategy to reproduce the process of epithelial–mesenchymal interaction in vitro could use a 3D system containing appropriate cell populations. The 3D air–liquid culture system for reproducibly generating hair follicles from dissociated epithelial and dermal papilla (DP) cells combined with a collagen–chitosan scaffold is des...
15 CitationsSource