Yun Zhou
Tongji University
Internal medicineUrologyDownregulation and upregulationOsteocalcinEndocrinologyBone remodelingKinaseChemistryIn vitroOsteoporosisBone mineralInflammasomeOsteoblastIcariinMAPK/ERK pathwayMedicineBiologyCell biologyProtein kinase APharmacology
11Publications
4H-index
151Citations
Publications 13
Newest
#1Ying Xue (Tongji University)H-Index: 1
#2Ran Li (Tongji University)H-Index: 2
Last. Yun Zhou (Tongji University)H-Index: 4
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BACKGROUND Sleeve gastrectomy (SG) is a profoundly effective operation for severe obese patients, but is closely associated with bone mass loss. Previous studies have reported changes of various serum factors which may be associated with bone mass loss after SG. However, those results are contradictory. In this study, we assessed the effects of SG on bone mass, microstructure of femurs, and changes in bone turnover markers (BTMs), serum adipokines, inflammatory factors and gastrointestinal hormo...
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#1Ying Xue (Tongji University)H-Index: 1
#2Ran Li (Tongji University)H-Index: 2
Last. Ling Li (Tongji University)H-Index: 2
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Gouty arthritis is a common inflammatory disease characterized by monosodium urate (MSU) crystal induced nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome activation with up-regulated caspase-1 protease and IL-1β in macrophages. Cucurbitacin B (CuB) is a tetracyclic triterpene that possesses a potential anti-inflammatory activity. However, the immunomodulatory and anti-inflammatory effects of CuB on gout have not been well c...
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#1Ling Li (Tongji University)H-Index: 2
#2Kelei Qian (Tongji University)
Last. Xinyu Hong (Tongji University)
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Diabetic nephropathy (DN) is a complication of diabetes that induces the development of end-stage renal disease (ESRD). The pathogenesis of DN is reported to be closely related to the activation of the NOD-like receptor 3 (NLRP3) inflammasome in renal glomerular endothelial cells. Omarigliptin is a novel dipeptidyl peptidase-4 (DPP-4) inhibitor developed for the management of type II diabetes, it has been recently reported to possess a significant anti-inflammatory property. This study aims to e...
1 CitationsSource
#1Xiao-yan Wu (Tongji University)H-Index: 1
#2Dunmin SheH-Index: 2
Last. Ying Xue (Tongji University)H-Index: 1
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Diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) are the two most common hyperglycemic emergencies (HEs) associated with diabetes mellitus. Individuals with HEs can present with combined features of DKA and HHS. The objective of this study is to assess the clinical characteristics, therapeutic outcomes, and associated predisposing factors of type 2 diabetic patients with isolated or combined HEs in China. We performed a retrospective analysis of 158 patients with type 2 dia...
3 CitationsSource
#1Qi Zhu (Tongji University)H-Index: 3
#2Chang Shan (Tongji University)H-Index: 1
Last. Yun Zhou (Tongji University)H-Index: 4
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Background: This study aimed to assess gene expression changes associated with hypoxia pathway on bone marrow stem cells (BMSCs) and explore effects of bone mass index (BMI) on hypoxia pathway of osteoporosis (OP) patients. Methods: Human BMSCs were isolated from bone marrow. Subjects were divided into healthy control group and OP group which was further divided into BMI Results: The genes downregulated in OP patients were involved in hypoxia pathway. Furthermore, those genes were even downregul...
4 CitationsSource
Objective The aim of this study was to explore the effect of low density lipoprotein(LDL) on the proliferation and differentiation of MC3T3-E1 osteoblasts, as well as the expression of low density lipoprotein receptor-related protein 5(LRP5) and dickkopf-1(DKK1) mRNA of MC3T3-E1 osteoblasts. The possible mechanisms of the treatment of atorvastatin on LDL expression in MC3T3-E1 osteoblasts were also investigated. Methods Proliferation, osteocalcin expression, LRP5, and expression of DKK1 mRNA of ...
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Objective: To investigate the clinical value of calcium load test in the differentiation of various types of hyperparathyroidism (HPT). Methods: A total of 56 healthy subjects (Control) and 68 patients with different types of HPT hyperparathyroidism were recruited into this study. Results: In primary HPT (PHPT) group, the inhibition rate of PTH (PTH-IR) was significantly smaller than those in Control, SHPT1 and CuHPT group (all P = 0.000). There was no significant difference in the PTH-IR among ...
3 Citations
Objective: Intermittent hypoxia was introduced to mimic obstructive sleep apnea-hypopnea syndrome (OSAHS) in rats. Then, bone mass, bone strength and bone turnover were evaluated, and the influence of genistein on bone mass reduction was investigated in these rats. Methods: OSAHS animal model was established via chronic intermittent hypoxia, and genistein (2.5 mg/kg/day) was used to treat OSAHS rats. The bone mineral density (BMD), bone Histomorphometric indicators, bone biomechanics and express...
18 Citations
#1Lige Song (Tongji University)H-Index: 10
#2Jiashen Zhao (Tongji University)H-Index: 1
Last. Yun Zhou (Tongji University)H-Index: 4
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Icariin, the main active flavonoid glucoside isolated from Herba epimedii (HEF), is an anabolic agent in bone that has been reported to prevent bone loss in ovariectomized rats and postmenopausal women. However, the molecular mechanism for this anabolic action of Icariin remain largely unknown. Here, we found that Icariin could promote MC3T3-E1 osteoblastic cell proliferation and reduce cell apoptosis, associated with increased mRNA levels of positive regulators of cell cycle gene Cyclin E and p...
119 CitationsSource
#1Miao Xuan (Tongji University)H-Index: 5
#2Jun Yang (Tongji University)H-Index: 1
Last. Yonglan Wang (Tongji University)H-Index: 1
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Objective An open study was carried out to evaluate the effect of 2 year of zoledronic acid and tibolone treatment on bone mineral density(BMD),bone remodeling markers,and the risk of fracture in women with postmenopausal osteoporosis(PMOP).Methods In total,567 PMOP women,whose ages ranged 55-64 years,were randomized to 3 groups.185 patients received infusion zoledronic acid 5 mg/year,190 patients received oral tibolone 2.5 mg/d and the rest received oral caltrate and calcitriol (control group,n...
1 CitationsSource