Lan Yuan
Peking University
EndocrinologyCellChemistryApoptosisTransferrinOxidative stressOxysterolOsteoblastNeuronNeurotoxicityCalcificationTriolExtracellularProgrammed cell deathTransferrin receptorReactive oxygen speciesBiochemistryMAPK/ERK pathwayBiologyCell biology
16Publications
10H-index
406Citations
Publications 15
Newest
#1Xudong Feng (PKU: Peking University)H-Index: 12
#2Qing Xia (PKU: Peking University)H-Index: 16
Last. Kui Wang (PKU: Peking University)H-Index: 24
view all 6 authors...
Gadolinium (Gd) and its complexes are utilized widely in industrial and clinical diagnoses. As a rare earth metal ion, free gadolinium (Gd3+) in the human body poses neurotoxic risks during its in vivo release and retention. In the central nervous system, astrocytes play a pivotal role in processing toxic metal ions. The present study evaluates the effects of Gd on cellular calcium homeostasis, a common mechanism that causes cell death, and on unfolded protein responses (UPRs), a mechanism for c...
20 CitationsSource
#1Qing Xia (PKU: Peking University)H-Index: 16
#2Xudong Feng (PKU: Peking University)H-Index: 12
Last. Xiaoda Yang (PKU: Peking University)H-Index: 24
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Gadolinium (Gd3+) complexes are important contrast agents in medical magnetic resonance imaging (MRI) and of great potential value in brain research. In order to better understand the mechanisms of the action of Gd3+ on neurons in the complex central nervous system (CNS), the neurotoxic actions of GdCl3 have been investigated in both neuron monoculture and astrocyte-neuron co-culture systems. Measurements of lactate dehydrogenase release showed that GdCl3 causes significant cell death of monocul...
6 CitationsSource
#1Xudong Feng (PKU: Peking University)H-Index: 12
#2Qing Xia (PKU: Peking University)H-Index: 16
Last. Kui Wang (PKU: Peking University)H-Index: 24
view all 5 authors...
Gadolinium (Gd), a rare-earth lanthanides metal, is widely utilized for various industrial and medical purposes, particularly in brain magnetic resonance imaging. However, its potential effects on the impairment of the central nervous system remain uncertain, especially with regard to the mitochondria, the potential primary target in metal-induced neural injury. This study investigates the effects of gadolinium on mitochondrial energy metabolism, ROS accumulation, and cell death toward cortical ...
74 CitationsSource
#1Lan Yuan (PKU: Peking University)H-Index: 10
#2Ping Du (PKU: Peking University)H-Index: 1
Last. Xiao-Gai Yang (PKU: Peking University)H-Index: 11
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Our present study provided new evidence for diterbium transferrin (Tb2Tf) as a potential multi-photon-excited microscopy probe. It indicated that the Tb2Tf complex can be transported into human leukemia K562 cells via a process mediated by transferrin (Tf) receptors as an intact entity and with no obvious cellular toxicity. The supporting evidence includes the following. First, the transport kinetic behavior of Tb was compared with that of the Tf moiety. The Tb was determined by inductively coup...
5 CitationsSource
#1Xi Wang (PKU: Peking University)H-Index: 4
#2Lan Yuan (PKU: Peking University)H-Index: 10
Last. Kui Wang (PKU: Peking University)H-Index: 13
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Converging lines of evidence suggest that lanthanum tends to deposit in bone. The influence of lanthanum ion (La 3+ ) on osteoblast differentiation and the related mechanism are essential to understanding its effect on bone metabolism. In this study, La 3+ treatment enhanced in vitro osteoblast differentiation as evidenced by promoting alkaline phosphatase (ALP) activity, osteocalcin (OC) secretion, and matrix mineralization. The expressions of osteoblast-specific genes of Cbfa-1, osteopontin (O...
52 CitationsSource
#1Hongmei Liu (PKU: Peking University)H-Index: 3
#2Lan Yuan (PKU: Peking University)H-Index: 10
Last. Kui Wang (PKU: Peking University)H-Index: 24
view all 4 authors...
The cellular and molecular mechanisms that mediate vascular calcification remain poorly understood. In our previous study, oxysterol cholestane-3β, 5α, 6β-triol (Triol) was shown to promote vascular smooth muscle cells (VSMCs) calcification. In this study, by using direct coculture, non-contact transwell coculture, and culture with conditioned media, we investigated the roles of endothelial cells (ECs) and macrophages in the regulation of VSMCs calcification in the absence or presence of Triol. ...
6 CitationsSource
#1Jian Huang (PKU: Peking University)H-Index: 12
#2Lan Yuan (PKU: Peking University)H-Index: 10
Last. Kui Wang (PKU: Peking University)H-Index: 24
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Abstract Icariin, a principal flavonoid glycoside in Herba Epimedii , is hypothesized to possess beneficial effects on bone mass. Icariin is metabolized to icariside II and then to icaritin in vivo. In the present study, we investigated the in vitro effects of icariin, icariside II and icaritin on both osteoblasts and osteoclasts. After treatment with these compounds at concentrations 10 − 5 –10 − 8 mol/l, osteoblasts were examined for proliferation, alkaline phosphatase activity, osteocalcin se...
208 CitationsSource
#1Hongmei Liu (PKU: Peking University)H-Index: 3
#2Lan Yuan (PKU: Peking University)H-Index: 10
Last. Tian-Lan Zhang (PKU: Peking University)H-Index: 15
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Converging lines of evidence suggest that oxidized lipids, long recognized as a risk factor in atherogenesis, also contribute to osteoporosis, but the underlying mechanism is not understood in detail. The effect of atherogenesis related factors including oxysterols on the differentiation and survival of marrow stromal cells (MSCs) would be very important in understanding the link between atherosclerosis and osteoporosis. In the present study, the effect of oxysterol cholestane-3β,5α,6β-triol (Tr...
24 CitationsSource
#1Siwang Yu (PKU: Peking University)H-Index: 29
#2Lan Yuan (PKU: Peking University)H-Index: 10
Last. Zhong Ming Qian (PolyU: Hong Kong Polytechnic University)H-Index: 2
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Lanthanum ion (La3+) has been reported to affect proliferation or apoptosis of different cells. In the present study, La3+ was confirmed to promote both proliferation and apoptosis of NIH 3T3 cells at the same concentrations. La3+ was shown to promote proliferation by helping the cells to pass through the G1/S restriction point and enter S phase, however, the proliferating cells induced by incubation with La3+ eventually underwent apoptosis. The proliferation and apoptosis of NIH 3T3 cells induc...
21 CitationsSource
#1Hong-Bo Zhao (PKU: Peking University)H-Index: 1
#2Sai-Zhen WangH-Index: 1
Last. Zhi-Bin Lin (PKU: Peking University)H-Index: 15
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The effect of Ganoderma total sterol (GS) and its main components(GS1) on rat cortical neuronal cultures exposed to hypoxia/reoxygenation (H/R) was studied in vitro. GS (0.01,0.1,1 μg/ml) increased neuron viability following H/R. GS also significantly reduced malondialdehyde content and reactive oxygen species production and increased manganese superoxide dismutase (Mn-SOD) activity; furthermore, the translocation of nuclear factor-kappa B and the production of interleukin-1β and tumor necrosis ...
20 CitationsSource
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