Peiyan Shan
Shandong University
Fusion proteinInternal medicineNeurosurgeryNeuropsychologySleep disorderMolecular biologyCerebral blood flowCardiologyNeurologyNeuroscienceApoptosisTranscranial DopplerNeuroprotectionPittsburgh Sleep Quality IndexNeuroglobinApathyEpworth Sleepiness ScaleDiseaseHypoxia (medical)DementiaCerebrospinal fluidNeuroradiologyMTT assayClinical Dementia RatingPulsatility indexCognitive declineVascular pathologySeverity of illnessImmunostainingAlzheimer's diseaseViability assayNeuroimagingMedicineCerebral autoregulationBiologyCell biology
4Publications
4H-index
34Citations
Publications 13
Newest
#1Shuangwu Liu (SDU: Shandong University)H-Index: 3
#2Qingguo Ren (SDU: Shandong University)
Last. Chuanzhu Yan (SDU: Shandong University)H-Index: 17
view all 25 authors...
To investigate atrophy patterns in hypothalamic subunits at different stages of ALS and examine correlations between hypothalamic subunit volume and clinical information. We used the King’s clinical staging system to divide 91 consecutive ALS patients into the different disease stages. We investigated patterns of hypothalamic atrophy using a recently published automated segmentation method in ALS patients and in 97 healthy controls. We recorded all subjects’ demographic and clinical information....
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#1Shuangwu Liu (SDU: Shandong University)H-Index: 3
#8Suyu Zhong (SDU: Shandong University)H-Index: 13
Neuroimaging studies of hippocampal volumes in patients with amyotrophic lateral sclerosis (ALS) have reported inconsistent results. Our aims were to demonstrate that such discrepancies are largely due to atrophy of different regions of the hippocampus that emerge in different disease stages of ALS and to explore the existence of co-pathology in ALS patients. We used the well-validated King's clinical staging system for ALS to classify patients into different disease stages. We investigated in v...
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#7Peiyan Shan (SDU: Shandong University)H-Index: 4
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#1Shuo Feng (SDU: Shandong University)
#2Xinjing Zhao (SDU: Shandong University)H-Index: 3
Last. Peiyan Shan (SDU: Shandong University)H-Index: 4
view all 11 authors...
Objective: We aimed to characterize the epidemiological and clinical characteristics of sporadic Creutzfeldt-Jakob disease (sCJD) in eastern China in this retrospective study. Methods: This study enrolled 67 patients with sCJD hospitalized in a grade-A tertiary hospital in eastern China from January 2010 to January 2020. Demographic data, clinical symptoms, brain magnetic resonance imaging (MRI), electroencephalogram (EEG), cerebrospinal fluid (CSF) 14-3-3 protein test, polymerase chain reaction...
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#7Peiyan Shan (SDU: Shandong University)H-Index: 4
Abstract Background: Migraine is the most common acute primary headache in children and adolescents. In 2014, topiramate became the first preventive drug for migraine approved by the Food and Drug Administration (FDA) in adolescents. This meta-analysis was aimed to evaluate the efficacy and safety of topiramate for the prevention of pediatric migraine. Methods: We searched the PubMed, EMBASE, Cochrane Library and Chinese National Knowledge Infrastructure (CNKI) databases up to June 2019 for elig...
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#2Shuangwu Liu (Peking Union Medical College Hospital)H-Index: 3
Alzheimer disease (AD) is the most common neurodegenerative brain disease that causes cognitive impairment in the elderly. Behavioral and psychological symptoms of dementia (BPSD), also known as neuropsychiatric symptoms, represent a heterogeneous group of non-cognitive symptoms and behaviors for AD patients. Sleep disorder is one closely-related psychiatric symptom of AD. In this cross-section study, we aimed to investigate the characteristics of sleep status and BPSD among AD patients in Easte...
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#3Peiyan Shan (SDU: Shandong University)H-Index: 4
Abstract In this study, we aimed to investigate the role of dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A), which is one of the most important regulators of Alzheimer's disease development, in islet β cell dysfunction and apoptosis. We found significantly increased expression of DYRK1A in both the hippocampus and pancreatic islets of APPswe/PS1ΔE9 transgenic mice than in wild-type littermates. Furthermore, we observed that the overexpression of DYRK1A greatly aggravat...
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#5Peiyan Shan (SDU: Shandong University)H-Index: 4
Subacute combined degeneration (SCD) is a relatively rare myelopathy mainly caused by vitamin B12 deficiency. There are many causes contributing to vitamin B12 deficiency. Autoimmune gastritis might lead to severe vitamin B12 malabsorption and in its advanced stage pernicious anemia (PA) may occur. Besides, long-term hypergastrinemia arising from achlorhydria in autoimmune gastritis is associated with neuroendocrine tumors (NETs). Patients diagnosed with SCD coexistent with PA and NET are seldom...
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#1Guoyu Zhou (SDU: Shandong University)H-Index: 2
#2Xinjing Zhao (SDU: Shandong University)H-Index: 3
Last. Lin Ma (SDU: Shandong University)H-Index: 6
view all 8 authors...
BACKGROUND: Vasculature changes have been observed in Alzheimer's disease (AD). AD-related vascular pathology might impair cerebral autoregulation (CA). OBJECTIVE: This study was designed to evaluate CA of AD patients by using transcranial doppler (TCD). METHODS: A total of 61 participants were included in the study, including 31 AD patients and 30 controls. The trend curves of cerebral blood flow velocities (CBFV), pulsatility index, and resistance index were obtained using TCD during supine-to...
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#1Yan Lin (SDU: Shandong University)H-Index: 2
#2Peiyan Shan (SDU: Shandong University)H-Index: 4
Last. Lin Ma (SDU: Shandong University)H-Index: 6
view all 5 authors...
Subjective cognitive decline (SCD), characterized by a very early and subtle cognitive decline prior to the appearance of objective cognitive impairment, is considered to be the preclinical manifestation of Alzheimer’s disease (AD). Given the lack of significant abnormalities in standardized neuropsychological assessments for individuals with SCD, biochemical and neuroimaging biomarkers may be important indicators of the preclinical stage of AD. The application of various biomarkers derived from...
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