Eleonore C.L. Bolle
Queensland University of Technology
Self-healing hydrogelsBiomedical engineeringFabricationKineticsCopolymerChemistryMaterials scienceCloud pointOxazolineHuman skinDermal fibroblastDrug deliveryPercutaneousMelt electrospinningChemical engineeringTissue engineeringPolymerPorosityMedicineScaffold
14Publications
2H-index
18Citations
Publications 14
Newest
#1Tim R. Dargaville (QUT: Queensland University of Technology)H-Index: 25
#2Damien G. Harkin (QUT: Queensland University of Technology)H-Index: 25
Last. Richard Hoogenboom (UGent: Ghent University)H-Index: 66
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A rapid photo-curing system based on poly(2-ethyl-2-oxazoline-co-2-allylamidopropyl-2-oxazoline) and its in vivo compatibility are presented. The base polymer was synthesized from the copolymerization of 2-ethyl-2-oxazoline (EtOx) and the methyl ester containing 2-methoxycarboxypropyl-2-oxazoline (C3MestOx) followed by amidation with allylamine to yield a highly water-soluble macromer. We showed that spherical hydrogels can be obtained by a simple water-in-oil gelation method using thiol-ene cou...
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Single-administration vaccine delivery systems are intended to improve the efficiency and efficacy of immunisation programs in both human and veterinary medicine. In this work, an osmotically triggered delayed delivery device was developed that was able to release a payload after a delay of approximately 21 days, in a consistent and reproducible manner. The device was constructed out of a flexible poly(e-caprolactone) photo-cured network fabricated into a hollow tubular shape, which expelled app...
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#1Jong Ryul Park (QUT: Queensland University of Technology)
#1Jong-Ryul Park (QUT: Queensland University of Technology)H-Index: 2
Last. Tim R. Dargaville (QUT: Queensland University of Technology)H-Index: 25
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Poly(2-alkyl-2-oxazoline) (PAOx) hydrogels are tailorable synthetic materials with demonstrated biomedical applications, thanks to their excellent biocompatibility and tunable properties. However, their use as injectable hydrogels is challenging as it requires invasive surgical procedures to insert the formed hydrogel into the body due to their nonsoluble 3D network structures. Herein, we introduce cyclooctyne and azide functional side chains to poly(2-oxazoline) copolymers to induce in situ gel...
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#1Eleonore C.L. Bolle (QUT: Queensland University of Technology)H-Index: 2
#2Deanna Nicdao (QUT: Queensland University of Technology)H-Index: 1
Last. Tim R. Dargaville (QUT: Queensland University of Technology)H-Index: 25
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Melt electrospinning writing (MEW) is a solvent-free fabrication method for making polymer fiber scaffolds with features which include large surface area, high porosity, and controlled deposition of the fibers. These scaffolds are ideal for tissue engineering applications. Here we describe how to produce scaffolds made from poly(e-caprolactone) using MEW and the seeding of primary human-derived dermal fibroblasts to create cell-scaffold constructs. The same methodology could be used with any num...
1 CitationsSource
#1Tao Liu (QUT: Queensland University of Technology)H-Index: 1
#2Eleonore C.L. Bolle (QUT: Queensland University of Technology)H-Index: 2
Last. Aurelien Forget (QUT: Queensland University of Technology)H-Index: 11
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1 CitationsSource
#1Jong-Ryul Park (QUT: Queensland University of Technology)H-Index: 2
#2Mariah Sarwat (QUT: Queensland University of Technology)H-Index: 1
Last. Tim R. Dargaville (QUT: Queensland University of Technology)H-Index: 25
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A dynamic thermo-responsive drug delivery concept using poly(2-oxazoline) copolymers conjugated with a hydrophobic drug is presented. The novel strategy entails the synthesis of copolymers comprising 2-n-propyl-2-oxazoline and 2-methoxycarbonylpropyl-2-oxazoline to which the drug, benazepril is conjugated via an ester linkage. The polymer without drug is non-toxic and has a cloud point temperature in aqueous conditions around 50 ○C meaning that it is soluble at body temperature. Yet, when conjug...
1 CitationsSource
#1Shuang Wang (QUT: Queensland University of Technology)H-Index: 1
#2Mariah Sarwat (QUT: Queensland University of Technology)H-Index: 1
Last. Tim R. Dargaville (QUT: Queensland University of Technology)H-Index: 25
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A method is reported for making hollow channels within hydrogels decorated with cell-adhesion peptides exclusively at the channel surface. Sacrificial fibers of different diameters are used to introduce channels within poly(ethylene glycol) hydrogels crosslinked with maleimide-thiol chemistry, which are backfilled with a cysteine-containing peptide solution which is conjugated to the lumen with good spatial efficiency. This allows for peptide patterning in only the areas of the hydrogel where th...
1 CitationsSource
#1Eleonore C.L. Bolle (QUT: Queensland University of Technology)H-Index: 2
#2Anthony D. Verderosa (QUT: Queensland University of Technology)H-Index: 4
Last. Makrina Totsika (QUT: Queensland University of Technology)H-Index: 35
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Percutaneous devices are a key technology in clinical practice, used to connect internal organs to external medical devices. Examples include prosthesis, catheters and electrical drivelines. Percutaneous devices breach the skin's natural barrier and create an entry point for pathogens, making device infections a widespread problem. Modification of the percutaneous implant surface to increase skin integration with the aim to reduce subsequent infection is attracting a great deal of attention. Whi...
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#1Eleonore C.L. Bolle (QUT: Queensland University of Technology)H-Index: 2
#2Nicole Bartnikowski (QUT: Queensland University of Technology)H-Index: 7
Last. Tim R. Dargaville (QUT: Queensland University of Technology)H-Index: 25
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The interface between synthetic percutaneous devices and skin is a common area for bacterial infection, which may ultimately result in failure of the device. Better integration of percutaneous devices with skin may help reduce infection rates due to the creation of a dermal seal. However, the mismatch in material and chemical properties of devices and skin presents a challenge for closing the dermal gap at the skin–device interface. Here, we have used a tissue engineering approach to tissue inte...
2 CitationsSource
#1Jong-Ryul Park (QUT: Queensland University of Technology)H-Index: 2
#2Joachim F. R. Van Guyse (UGent: Ghent University)H-Index: 6
Last. Tim R. Dargaville (QUT: Queensland University of Technology)H-Index: 25
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Abstract Four drug-conjugated poly(2-alkyl-2-oxazoline) (PAOx) networks with different hydrophobicity were synthesized via copolymerization of either 2-methyl-, 2-ethyl-, 2-propyl- or 2-butyl-2-oxazoline with the functional monomer, 2-dec-9-enyl-2-oxazoline. The incorporation of a labile ester linkage between the polymer and the drug benazepril allowed for sustained drug release over periods of months with the release rates strongly depending on the hydrophobicity of the polymer pendant groups. ...
8 CitationsSource