Sebastian Schotten
University of Mainz
Survival analysisLikert scaleCancerInternal medicineRadiologyUrologySurgeryPathologyMagnetic resonance imagingUnivariate analysisResectionConcordanceRetrospective cohort studyPhysical therapySubgroup analysisRadiological weaponPredictive value of testsCohort studyPsychological interventionAneurysmSarcopeniaLiver cancerRenal arteryThoracic aortaCeliac arteryLiver diseaseVeinCirrhosisInfiltration (medical)May–Thurner syndromeHepatocellular carcinomaMagnetic resonance angiographyAscending aortaSorafenibProsthesisAblationClaudicationPortal veinChronic liver diseaseSelective internal radiation therapyLiver transplantationAortaSurgical oncologyCancer stagingSplenic arterySubspecialtyAngiographyDescending aortaInsulin-like growth factorLymphadenectomyThrombosisAcute aortic syndromeEnthusiasmLeft portal veinIntrahepatic CholangiocarcinomaAorta descendensAorta ascendensCarbohydrate antigenVascular PatencyVascular MedicineGynecologyScoring systemArea under the roc curveInternal validationLiver functionVascular biologyBlood vessel prosthesisReferral centerClinical routineMedical journalIn patientPoor prognosisSimulation trainingIncreased riskExternal validationPatient survivalOpen surgeryMedian survivalAdvanced stageMissed diagnosisAttractivenessBrier scoreMultivariate analysisIncidence (epidemiology)Predictive modellingCurriculumProportional hazards modelRisk factorArtificial neural networkMedical educationRadiation therapyInterventional radiologyIschemiaGeneral surgeryClinical significanceLog-rank testMedicineCohortComplicationGastroenterology
25Publications
6H-index
182Citations
Publications 25
Newest
#1Aline Mähringer-Kunz (University of Mainz)H-Index: 5
#2Franziska I Meyer (University of Cologne)
Last. Sebastian Schotten (University of Mainz)H-Index: 6
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BACKGROUND There is strong evidence that portal vein tumor thrombosis (PVTT) is associated with poor survival in patients with hepatocellular carcinoma (HCC). However, data regarding the clinical significance of hepatic vein tumor thrombosis (HVTT) is rare, particularly in Western patients. OBJECTIVE To determine the HVTT prevalence in a Western patient population and its impact on survival. METHODS We included 1310 patients with HCC treated in our tertiary referral center between January 2005 a...
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#2Verena Steinle (University Hospital Heidelberg)H-Index: 1
Last. Arndt WeinmannH-Index: 29
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Background Portal vein tumor thrombosis (PVTT) is a frequent complication of hepatocellular carcinoma (HCC), which leads to classification as advanced stage disease (regardless of the degree of PVTT) according to the Barcelona Clinic Liver Cancer Classification. For such patients, systemic therapy is the standard of care. However, in clinical reality, many patients with PVTT undergo different treatments, such as resection, transarterial chemoembolization (TACE), selective internal radiation ther...
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#2Sebastian SchottenH-Index: 6
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#1Fabian Stoehr (University of Mainz)
#2Sebastian Schotten (University of Mainz)H-Index: 6
Last. Daniel Pinto dos SantosH-Index: 12
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OBJECTIVES: Interventional radiology (IR) is a growing field but is underrepresented in most medical school curricula. We tested whether endovascular simulator training improves medical students' attitudes towards IR. MATERIALS AND METHODS: We conducted this prospective study at two university medical centers; overall, 305 fourth-year medical students completed a 90-min IR course. The class consisted of theoretical and practical parts involving endovascular simulators. Students completed questio...
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#1Aline Mähringer-Kunz (University of Mainz)H-Index: 5
#2Franziska Wagner (University of Mainz)H-Index: 1
Last. Roman Kloeckner (University of Mainz)H-Index: 14
view all 11 authors...
BACKGROUND AND AIMS: Deciding when to repeat and when to stop transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC) can be difficult even for experienced investigators. Our aim was to develop a survival prediction model for such patients undergoing TACE using novel machine learning algorithms and to compare it to conventional prediction scores, ART, ABCR and SNACOR. METHODS: For this retrospective analysis, 282 patients who underwent TACE for HCC at our tertiary ...
11 CitationsSource
#1Felix Hahn (University of Mainz)H-Index: 6
#2Lukas Müller (University of Mainz)H-Index: 4
Last. Roman Kloeckner (University of Mainz)H-Index: 14
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Background External validation of prognostic risk models is essential before they are implemented in clinical practice. This study evaluated the recently developed MEGNA score for survival prediction after resection of intrahepatic cholangiocarcinoma (ICC), with a focus on the direct comparison of its prognostic value to that of the current International Union Against Cancer (UICC)/American Joint Committee on Cancer (AJCC) Cancer staging system. Material and methods Between 1997 and 2018, 417 co...
2 CitationsSource
#1Felix Hahn (University of Mainz)H-Index: 6
#2Lukas Müller (University of Mainz)H-Index: 4
Last. Roman Kloeckner (University of Mainz)H-Index: 14
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BACKGROUND & AIMS: Sarcopenia has emerged as a prognostic parameter in numerous cancer entities. Current research favours its role as a determining factor for overall survival (OS) in patients with intrahepatic cholangiocarcinoma (ICC); however, it is unclear whether sarcopenia is a truly independent survival predictor if combined with established prognostic factors. METHODS: Between 1997-2018, 417 patients with histopathologically confirmed ICC were referred to our centre, of whom 293 were incl...
9 CitationsSource
#1Roman Kloeckner (University of Mainz)H-Index: 14
#2F Wagner (University of Mainz)
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Source
#1Aline Mähringer-Kunz (University of Mainz)H-Index: 5
#2V. Steinle (University of Mainz)H-Index: 2
Last. Roman Kloeckner (University of Mainz)H-Index: 14
view all 12 authors...
BACKGROUND & AIMS: Portal vein tumour thrombosis (PVTT) has a significant impact on the prognosis of patients with hepatocellular carcinoma (HCC). The degree of PVTT varies from sub-/segmental invasion to complete occlusion of the main trunk. Aim of this study was to evaluate whether the degree of PVTT correlates with prognosis. METHODS: A total of 1317 patients with HCC treated at our tertiary referral centre between January 2005 and December 2016 were included. PVTT was diagnosed by contrast-e...
16 CitationsSource
#1Yvonne Huber (University of Mainz)H-Index: 10
#2Franziska Bierling (University of Mainz)H-Index: 1
Last. Julia Weinmann-Menke (University of Mainz)H-Index: 9
view all 13 authors...
In hepatocellular carcinoma (HCC), the third leading cause of cancer-related mortality worldwide, the Child-Turcotte-Pugh score (CTP) is one of the most established tools to assess hepatic reserve and determine survival. Serum levels of insulin-like growth factor-1 (IGF-1) are decreased in patients with chronic liver disease or HCC. A modified score combining circulating IGF-1 with the CTP score (IGF-CTP) was recently proposed. IGF-CTP scoring was evaluated in 216 patients diagnosed with HCC bet...
6 CitationsSource