R. Daniel Rudic
Georgia Regents University
Circadian rhythmInternal medicineEndocrinologyNeuroscienceChemistryEndotheliumVascular diseaseEnosVascular smooth muscleNADPH oxidaseSuperoxideEndothelial dysfunctionNitric Oxide Synthase Type IIIAngiotensin IICircadian clockReactive oxygen speciesMedicineBlood pressureBiologyCell biology
Publications 36
#1Qimei Han (Georgia Regents University)
#2Zyare J Orr (Georgia Regents University)
Last. R. Daniel Rudic (Georgia Regents University)H-Index: 19
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#1Ramon C. Hermida (University of Texas at Austin)H-Index: 74
#2Michael H. Smolensky (University of Texas at Austin)H-Index: 35
Last. Xiaoyun ZhaoH-Index: 1
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Current hypertension guidelines fail to provide a recommendation on when-to-treat, thus disregarding relevant circadian rhythms that regulate blood pressure (BP) level and 24 h patterning and medic...
9 CitationsSource
#1David Fulton (Georgia Regents University)H-Index: 72
#2Xueyi Li (Georgia Regents University)H-Index: 6
Last. Scott A. Barman (Georgia Regents University)H-Index: 21
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Abstract Significance: Pulmonary arterial hypertension (PAH) is a progressive disease arising from the narrowing of pulmonary arteries (PAs) resulting in high pulmonary arterial blood pressure and ...
5 CitationsSource
Atherosclerosis is a leading cause of death despite the improvements in lipid and blood pressure control. The circadian clock, a molecular network of genes and proteins that controls 24-hour timing...
#1Yusi Wang (Georgia Regents University)H-Index: 12
#2Paramita Pati (Georgia Regents University)H-Index: 5
Last. David Fulton (Georgia Regents University)H-Index: 72
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The circadian clock is a transcriptional network that functions to regulate the expression of genes important in the anticipation of changes in cellular and organ function. Recent studies have revealed that the recognition of pathogens and subsequent initiation of inflammatory responses are strongly regulated by a macrophage-intrinsic circadian clock. We hypothesized that the circadian pattern of gene expression might be influenced by inflammatory stimuli and that loss of circadian function in i...
25 CitationsSource
#1Paramita Pati (UK: University of Kentucky)H-Index: 5
#2David J.R. Fulton (UK: University of Kentucky)H-Index: 1
Last. R. Daniel Rudic (UK: University of Kentucky)H-Index: 19
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Blood pressure exhibits a robust circadian rhythm in health. In hypertension, sleep apnea, and even shift work, this balanced rhythm is perturbed via elevations in night-time blood pressure, inflicting silent damage to the vasculature and body organs. Herein, we examined the influence of circadian dysfunction during experimental hypertension in mice. Using radiotelemetry to measure ambulatory blood pressure and activity, the effects of angiotensin II administration were studied in wild-type (WT)...
21 CitationsSource
#1Xia Shang (Georgia Regents University)H-Index: 1
#2Paramita PatiH-Index: 5
Last. R. Daniel RudicH-Index: 19
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The circadian clock is rhythmically expressed in blood vessels, but the interaction between the circadian clock and disturbed blood flow remains unclear. We examined the relationships between BMAL1 and CLOCK and 2 regulators of endothelial function, AKT1 and endothelial nitric oxide synthase (eNOS), in vascular regions of altered blood flow. We found that the aortic arch from WT mice exhibited reduced sensitivity to acetylcholine (Ach)-mediated relaxation relative to the thoracic aorta. In Clock...
11 CitationsSource
#1R. Daniel Rudic (Georgia Regents University)H-Index: 19
Circadian rhythms play an important role in the cardiovascular system, affecting normal physiology and pathology. While circadian rhythms in blood pressure have long been known, the emergence of our understanding of the tissue pervasiveness and ubiquity of circadian clocks has elucidated additional roles of clocks in the cardiovascular system with regard to physiology, signaling, and disease. The key conduit of the circulatory system, the blood vessels, has their own vascular clocks as do all cr...
#1R. Daniel Rudic (Georgia Regents University)H-Index: 19
#1Ciprian B. Anea (Georgia Regents University)H-Index: 7
#2Maoxiang Zhang (Georgia Regents University)H-Index: 2
Last. R. Daniel Rudic (Georgia Regents University)H-Index: 19
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Recent studies have shown that circadian clock disruption is associated with pathological remodeling in the arterial structure and vascular stiffness. Moreover, chronic circadian disruption is associated with dysfunction in endothelial responses and signaling. Reactive oxygen species have emerged as key regulators in vascular pathology. Previously, we have demonstrated that circadian clock dysfunction exacerbates superoxide production through eNOS uncoupling. To date, the impact of circadian clo...
22 CitationsSource