Giovanni Fellin
Quality of lifeInternal medicineRadiologyUrologySurgeryOncologyProstateFecal incontinenceHormonal therapyAbdominal surgeryProstate cancerPopulationToxicityRectal toxicityIn patientInterstitial brachytherapyNomogramArtificial neural networkRadiation therapyMedicine
69Publications
7H-index
315Citations
Publications 69
Newest
#1Mauro CarraraH-Index: 16
#2Eleonora MassariH-Index: 2
Last. Riccardo Valdagni (University of Milan)H-Index: 51
view all 16 authors...
Purpose This study was designed to apply artificial neural network (ANN) classification methods for the prediction of late fecal incontinence (LFI) after high-dose prostate cancer radiation therapy and to develop a ready-to-use graphical tool. Materials and Methods In this study, 598 men recruited in 2 national multicenter trials were analyzed. Information was recorded on comorbidity, previous abdominal surgery, use of drugs, and dose distribution. Fecal incontinence was prospectively evaluated ...
4 CitationsSource
#2Tiziana RancatiH-Index: 27
Last. Riccardo Valdagni (University of Milan)H-Index: 51
view all 16 authors...
Purpose To develop a modelling procedure for late rectal bleeding (LRB) that goes beyond maximum likelihood model fitting of data. Thus, to create a metamodel for grade 2–3 (G23) and grade 3 (G3) LRB starting from literature evidence and validate it on a large population. Methods Metamodelling allows to highlight specific features of the model itself. Characteristics that predictive models for LRB have in common are: the global harmony of radiobiological parameters (volume effect parameter, n, s...
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#1Alessandro Cicchetti (UNIPV: University of Pavia)H-Index: 7
#2Barbara AvuzziH-Index: 11
Last. Riccardo Valdagni (University of Milan)H-Index: 51
view all 13 authors...
Purpose This study aimed to validate a previously published predictive model for late fecal incontinence (FI) in a contemporary population of prostate cancer patients treated with radical radiation therapy. Methods and Materials The validation included patients treated with intensity-modulated radiation therapy (IMRT) (2010-2014). Prescribed dose range was 65-80 Gy, including conventional and moderate hypo-fractionated treatments. Rectal toxicity was scored using LENT/SOMA, a minimum 2-year foll...
8 CitationsSource
#2Tiziana RancatiH-Index: 27
Last. Riccardo ValdagniH-Index: 51
view all 16 authors...
Source
61Background: Predictive models for late rectal bleeding (LRB) after radiotherapy (RT) for prostate cancer were established by several studies, with good performance on development population (POP). Nonetheless, they were found to be unsatisfactory in their generalization to independent validation cohorts. Aim of the study is to build a metamodel for grade 2-3 (G23) and grade 3 (G3) LRB (LENT/SOMA) starting from literature evidence and to validate it on a new POP. Methods: The metamodel was cons...
1 CitationsSource
#2Tiziana RancatiH-Index: 27
Last. R. ValdagniH-Index: 4
view all 16 authors...
#1E. MassariH-Index: 1
#2Tiziana RancatiH-Index: 27
Last. M CarraraH-Index: 6
view all 11 authors...
1 CitationsSource
#2Barbara AvuzziH-Index: 11
Last. R. ValdagniH-Index: 4
view all 12 authors...
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116Background: To validating a predictive model for late fecal incontinence (FI) on a recent population (pop) of prostate cancer patients (pts) treated with radical radiotherapy. NTCP model was derived from literature. Methods: Pop included 267 pts treated with IMRT in 2010-2014. Prescribed dose was between 68 and 80 Gy with conventional and hypo-fractionated (HF, from 2.2 to 2.8 Gy) treatment. Rectal toxicity was scored using the LENT/SOMA. Follow-up (FU) was considered up to 2 years. We chose ...
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Objective:Low-dose-rate brachytherapy (LDR-BT) in localized prostate cancer is available since 15 years in Italy. We realized the first national multicentre and multidisciplinary data collection to evaluate LDR-BT practice, given as monotherapy, and outcome in terms of biochemical failure.Methods:Between May 1998 and December 2011, 2237 patients with early-stage prostate cancer from 11 Italian community and academic hospitals were treated with iodine-125 (125I) or palladium-103 LDR-BT as monothe...
11 CitationsSource