Cheng Zong
Boston University
PlasmonAnalytical chemistryOpticsBiophysicsMicroscopyNanoparticleRaman scatteringNanotechnologyPhotothermal therapyChemistryMaterials scienceSurface-enhanced Raman spectroscopyStaphyloxanthinRaman spectroscopyMembraneOptoelectronicsAntibioticsElectrochemistryChemical imagingMicrobiologyAntibiotic resistance
50Publications
18H-index
1,599Citations
Publications 45
Newest
#1Yi Zhang (BU: Boston University)H-Index: 4
#2Haonan Zong (BU: Boston University)H-Index: 2
Last. Ji-Xin ChengH-Index: 83
view all 7 authors...
Mid-infrared photothermal microscopy is a new chemical imaging technology in which a visible beam senses the photothermal effect induced by a pulsed infrared laser. This technology provides infrared spectroscopic information at submicrometer spatial resolution and enables infrared spectroscopy and imaging of living cells and organisms. Yet, current mid-infrared photothermal imaging sensitivity suffers from a weak dependence of scattering on the temperature, and the image quality is vulnerable to...
1 CitationsSource
#1Haonan Lin (BU: Boston University)H-Index: 6
#2Hyeon Jeong Lee (ZJU: Zhejiang University)H-Index: 10
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 11 authors...
Label-free vibrational imaging by stimulated Raman scattering (SRS) provides unprecedented insight into real-time chemical distributions. Specifically, SRS in the fingerprint region (400–1800 cm−1) can resolve multiple chemicals in a complex bio-environment. However, due to the intrinsic weak Raman cross-sections and the lack of ultrafast spectral acquisition schemes with high spectral fidelity, SRS in the fingerprint region is not viable for studying living cells or large-scale tissue samples. ...
6 CitationsSource
#1Yi ZhangH-Index: 4
#2Haonan ZongH-Index: 2
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 7 authors...
Mid-infrared photothermal microscopy is a new chemical imaging technology in which a visible beam senses the photothermal effect induced by a pulsed infrared laser. This technology provides infrared spectroscopic information at sub-micron spatial resolution and enables infrared spectroscopy and imaging of living cells and organisms. Yet, current mid-infrared photothermal imaging sensitivity suffers from a weak dependance of scattering on temperature and the image quality is vulnerable to the spe...
#1Cheng Zong (BU: Boston University)H-Index: 18
#2Chi Zhang (BU: Boston University)
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 8 authors...
Traditional electrochemical measurements based on either current or potential responses only present the average contribution of an entire electrode's surface. Here, we present an electrochemical photothermal reflectance microscope (EPRM) in which a potential-dependent nonlinear photothermal signal is exploited to map an electrochemical process with sub-micron spatial resolution. By using EPRM, we are able to monitor the photothermal signal of a Pt electrode during the electrochemical reaction a...
2 CitationsSource
#1Cheng Zong (BU: Boston University)H-Index: 18
#2Yurun Xie (DICP: Dalian Institute of Chemical Physics)H-Index: 1
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 6 authors...
Plasmon-enhanced coherent Raman scattering microscopy has reached single-molecule detection sensitivity. Due to the different driven fields, there are significant differences between a coherent Raman scattering process and its plasmon-enhanced derivative. The commonly accepted line shapes for coherent anti-Stokes Raman scattering and stimulated Raman scattering do not hold for the plasmon-enhanced condition. Here, we present a theoretical model that describes the spectral line shapes in plasmon-...
2 CitationsSource
#1Pu-Ting Dong (BU: Boston University)H-Index: 6
#2Cheng Zong (BU: Boston University)H-Index: 18
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 9 authors...
Ergosterol-targeting amphotericin B (AmB) is the first line of defense for life-threatening fungal infections. Two models have been proposed to illustrate AmB assembly in the cell membrane; one is the classical ion channel model in which AmB vertically forms transmembrane tunnel and the other is a recently proposed sterol sponge model where AmB is laterally adsorbed onto the membrane surface. To address this controversy, we use polarization-sensitive stimulated Raman scattering from fingerprint ...
2 CitationsSource
#1Cheng Zong (Ha Tai: Xiamen University)H-Index: 18
#2Chan-juan Chen (Ha Tai: Xiamen University)H-Index: 1
Last. Bin Ren (Ha Tai: Xiamen University)H-Index: 80
view all 6 authors...
Surface-enhanced Raman spectroscopy (SERS) is a powerful tool to monitor various interfacial behaviors providing molecular level information with high spatial and temporal resolutions. However, it is a challenge to obtain SERS spectra with high quality for analytes having a weak binding affinity with plasmonic nanostructures due to the short dwell time of the analyte on the surface. Here, we employed dynamic SERS, an acquisition method consisting of the rapid acquisition of a series of consecuti...
2 CitationsSource
#1Hao He (Ha Tai: Xiamen University)H-Index: 2
#2Chun Lin (Ha Tai: Xiamen University)H-Index: 2
Last. Bin Ren (Ha Tai: Xiamen University)H-Index: 80
view all 8 authors...
1 CitationsSource
#1Meng Zhang (BU: Boston University)H-Index: 1
#2Weili Hong (BU: Boston University)H-Index: 4
Last. Ji-Xin ChengH-Index: 83
view all 9 authors...
Rapid antimicrobial susceptibility testing (AST) is urgently needed for treating infections with appropriate antibiotics and slowing down the emergence of antibiotic-resistant bacteria. Here, a phenotypic platform that rapidly produces AST results by femtosecond stimulated Raman scattering imaging of deuterium oxide (D2O) metabolism is reported. Metabolic incorporation of D2O into biomass in a single bacterium and the metabolic response to antibiotics are probed in as short as 10 min after cultu...
14 CitationsSource
#1Cheng Zong (BU: Boston University)H-Index: 18
#2Ji-Xin ChengH-Index: 83
2 CitationsSource