Yimin Huang
Boston University
PlasmonBiological neural networkTemporal resolutionOpticsBiophysicsNanomaterialsUltrasoundMicroscopyNeuromodulation (medicine)NanoparticleThermal decompositionCatalysisRaman scatteringNanotechnologyUltrashort pulseMetal-organic frameworkPhotothermal therapyChemistryMaterials scienceOptical fiberIn vitroImage resolutionIn vivoStimulationPhotothermal effectBuckminsterfullereneNickel cationGas phaseRaman spectroscopyChemical engineeringNanomaterial-based catalystCommon emitterNanoporousOptoelectronicsBiomoleculeLaserLithiumPhotoacoustic imaging in biomedicineChemical imagingPorosityMicroscopeSonoporationAnodeScaffold
24Publications
10H-index
839Citations
Publications 20
Newest
#1Yimin Huang (BU: Boston University)H-Index: 10
#2Ying Jiang (BU: Boston University)H-Index: 4
Last. Chen Yang (BU: Boston University)H-Index: 69
view all 6 authors...
Toward non-genetic non-invasive neural modulation with a submillimeter precision, we report the development and application of photoacoustic nanotransducers (PAN) to neural stimulation in cultured primary neurons and in live brain. Our PAN, based on synthesized semiconducting polymer nanoparticles, efficiently generate localized ultrasound by a photoacoustic process upon absorption of nanosecond pulsed light in the NIR-II window. We showed that PAN binding on the neuron membrane through non-spec...
Source
#1Ying Jiang (BU: Boston University)H-Index: 4
#2Yimin Huang (BU: Boston University)H-Index: 10
Last. Lu Lan (BU: Boston University)H-Index: 12
view all 15 authors...
Summary Neuromodulation is an invaluable approach for the study of neural circuits and clinical treatment of neurological diseases. Here, we report semiconducting polymer nanoparticles based photoacoustic nanotransducers (PANs) for neural stimulation in vitro and in vivo. Our PANs strongly absorb the nanosecond pulsed laser in the near-infrared second window (NIR-II) and generate localized acoustic waves. PANs are shown to be surface modified and selectively bind onto neurons. PAN-mediated activ...
1 CitationsSource
#1Cheng Zong (BU: Boston University)H-Index: 18
#2Yurun Xie (DICP: Dalian Institute of Chemical Physics)H-Index: 1
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 6 authors...
Plasmon-enhanced coherent Raman scattering microscopy has reached single-molecule detection sensitivity. Due to the different driven fields, there are significant differences between a coherent Raman scattering process and its plasmon-enhanced derivative. The commonly accepted line shapes for coherent anti-Stokes Raman scattering and stimulated Raman scattering do not hold for the plasmon-enhanced condition. Here, we present a theoretical model that describes the spectral line shapes in plasmon-...
2 CitationsSource
#1Linli Shi (BU: Boston University)H-Index: 1
#2Ying Jiang (BU: Boston University)H-Index: 4
Last. Chen Yang (BU: Boston University)H-Index: 69
view all 7 authors...
Abstract Focused ultrasound has attracted great attention in minimally invasive therapeutic and mechanism studies. Frequency below 1 MHz is identified preferable for high-efficiency bio-modulation. However, the poor spatial confinement of several millimeters and large device diameter of ∼25 mm of typical sub-MHz ultrasound technology suffered from the diffraction limit, severely hindering its further applications. To address it, a fiber-based optoacoustic emitter (FOE) is developed, serving as a...
4 CitationsSource
#1Yimin Huang (BU: Boston University)H-Index: 10
#2Vincent Fitzpatrick (Tufts University)H-Index: 3
Last. Chen Yang (BU: Boston University)H-Index: 69
view all 8 authors...
Biomaterial scaffold designs are needed for self-organizing features related to tissue formation while also simplifying the fabrication processes involved. Toward this goal, silk protein-based self-folding scaffolds to support 3D cell culture, while providing directional guidance and promotion of cell growth and differentiation, are reported. A simple and robust one-step self-folding approach is developed using bilayers consisting of a hydrogel and silk film in aqueous solution. The 3D silk roll...
5 CitationsSource
#1Yimin Huang (BU: Boston University)H-Index: 10
#2Ying Jiang (BU: Boston University)H-Index: 4
Last. Chen Yang (BU: Boston University)H-Index: 69
view all 13 authors...
Neuromodulation is an invaluable approach for study of neural circuits and clinical treatment of neurological diseases. Here, we report semiconducting polymer nanoparticles based photoacoustic nanotransducers (PANs) for neural stimulation. Our PANs strongly absorb light in the near-infrared second window and generate localized acoustic waves. PANs can also be surface-modified to selectively bind onto neurons. PAN-mediated activation of primary neurons in vitro is achieved with ten 3-nanosecond l...
Source
Hemozoin, the heme detoxification end product in malaria parasites during their growth in the red blood cells (RBCs), serves as an important marker for diagnosis and treatment target of malaria disease. However, the current method for hemozoin-targeted drug screening mainly relies on in-vitro β-hematin inhibition assays, which may lead to false-positive events due to under-representation of the real hemozoin crystal. Quantitative in-situ imaging of hemozoin is highly desired for high-throughput ...
6 CitationsSource
#1Cheng Zong (BU: Boston University)H-Index: 18
#2Ranjith Premasiri (BU: Boston University)H-Index: 2
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 9 authors...
Stimulated Raman scattering (SRS) microscopy allows for high-speed label-free chemical imaging of biomedical systems. The imaging sensitivity of SRS microscopy is limited to ~10 mM for endogenous biomolecules. Electronic pre-resonant SRS allows detection of sub-micromolar chromophores. However, label-free SRS detection of single biomolecules having extremely small Raman cross-sections (~10−30 cm2 sr−1) remains unreachable. Here, we demonstrate plasmon-enhanced stimulated Raman scattering (PESRS)...
22 CitationsSource
#1Linli ShiH-Index: 1
#2Ying JiangH-Index: 4
Last. Chen YangH-Index: 69
view all 7 authors...
Focused ultrasound has attracted great attention in minimally invasive therapy, gene delivery, brain stimulation, etc. Frequency below 1 MHz has been identified preferable for high-efficacy drug delivery, gene transfection and neurostimulation due to minimized tissue heating and cell fragmentation. However, the poor spatial resolution of several millimeters and the large device diameter of ~25 mm of current sub-MHz ultrasound technology severely hinders its further applications for effective, pr...
#1Yeran BaiH-Index: 5
#2Delong Zhang (BU: Boston University)H-Index: 21
Last. Ji-Xin ChengH-Index: 83
view all 7 authors...
Infrared (IR) imaging has become a viable tool for visualizing various chemical bonds in a specimen. The performance, however, is limited in terms of spatial resolution and imaging speed. Here, instead of measuring the loss of the IR beam, we use a pulsed visible light for high-throughput, widefield sensing of the transient photothermal effect induced by absorption of single mid-IR pulses. To extract these transient signals, we built a virtual lock-in camera synchronized to the visible probe and...
31 CitationsSource