Xin Zhou
Sichuan University
AmeloblastRegenerative medicineSelf-healing hydrogelsDownregulation and upregulationAmine gas treatingMetabolomePathologymicroRNARemineralisationCellular differentiationDental alveolusEnamel paintComposite materialPulp cappingCell fate determinationBone remodelingRegeneration (biology)KinaseChemistryPulp (tooth)DNA methylationMaterials scienceMetabolic pathwayMesenchymal stem cellAmelogenesisDentistryThree prime untranslated regionSLC4A4Dental follicleRUNX2Permanent teethVascular endothelial growth factorPeriapical periodontitisBiocompatibilityDental pulp stem cellsCementumEpiregulinApical foramenOsteoblastPeriodontiumBiomaterialRegenerative endodonticsPulp necrosisDentinPulpitisChitosanRoot canalEndodonticsPeriodontitisCraniofacialStem cellPermanent toothEnamel mineralizationMetabolic ProcessPrimary ToothDentinal TubulePAMAM dendrimerApexificationRoot canal anatomyDemineralized dentinEpigeneticsPeriodontal fiberChemical engineeringp38 mitogen-activated protein kinasesBiochemistryCementoblastMAPK/ERK pathwayHistoneBone resorptionMedicineBiologyCell biologyProtein kinase AIon transporter
10Publications
6H-index
98Citations
Publications 10
Newest
#1Dixin Cui (Sichuan University)H-Index: 5
#2Sihan Yu (Sichuan University)
Last. Mian Wan (Sichuan University)H-Index: 9
view all 8 authors...
Dental caries and trauma always lead to pulp necrosis and subsequent root development arrest of young permanent teeth. The traditional treatment, apexification, with absence of further root formation, results in abnormal root morphology and compromises long-term prognosis. Regeneration endodontics procedures (REPs) have been developed and considered as an alternative strategy for management of immature permanent teeth with pulpal necrosis, including cell-free REPs and cell-based REPs. Cell-free ...
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#1Dan Zhou (Sichuan University)
#2Lu Gan (Sichuan University)H-Index: 1
Last. Wei Du (Sichuan University)H-Index: 8
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Epigenetic regulation, mainly involving DNA methylation, histone modification, and noncoding RNAs, affects gene expression without modifying the primary DNA sequence and modulates cell fate. Mesenchymal stem cells derived from dental pulp, also called dental pulp stem cells (DPSCs), exhibit multipotent differentiation capacity and can promote various biological processes, including odontogenesis, osteogenesis, angiogenesis, myogenesis, and chondrogenesis. Over the past decades, increased attenti...
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#1Yi Yu (Sichuan University)H-Index: 2
#2Xin Zhou (Sichuan University)H-Index: 6
Last. Liwei Zheng (Sichuan University)H-Index: 17
view all 3 authors...
Primary tooth root canal therapy is a treatment performed on primary teeth diagnosed with pulpitis or periapical periodontitis. This procedure requires perfect instrumentation, disinfection, and filling of root canals to eliminate infection, control inflammation, relieve pain, prevent pathological effects on inherited permanent tooth, and prolong primary tooth preservation. This paper reviews the research history on primary tooth root canal treatment and summarizes the progress on primary tooth ...
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#1Si Wu (Sichuan University)H-Index: 3
#2Yachuan Zhou (Sichuan University)H-Index: 9
Last. Liwei Zheng (Sichuan University)H-Index: 17
view all 10 authors...
The pulpotomy with pulp capping is aimed at retaining vital pulp with reparative dentin formation. Vascular endothelial growth factor (VEGF) plays a crucial role in dentin regeneration; however, its constant administrations in the human body is still problematic. Chitosan was widely studied as an effective carrier to deliver bioactive molecules in regenerative medicine. In this study, we conducted a chitosan/β-glycerophosphate (CS/β-GP) hydrogel as a VEGF-sustained release system and explored it...
8 CitationsSource
#1Dixin Cui (Sichuan University)H-Index: 5
#2Jiani Xiao (Sichuan University)H-Index: 1
Last. Liwei Zheng (Sichuan University)H-Index: 17
view all 12 authors...
OBJECTIVES: The odontoblastic differentiation of dental pulp stem cells (DPSCs) contributes to tertiary dentin formation. Our previous study indicated that epiregulin (EREG) enhanced odontogenesis potential of dental pulp. Here, we explored the effects of EREG during DPSC odontoblastic differentiation. METHODS: The changes in EREG were detected during tertiary dentin formation. DPSCs were treated with recombinant human EREG (rhEREG), EREG receptor inhibitor gefitinib and short hairpin RNAs. The ...
9 CitationsSource
#1Tao Zhou (Sichuan University)H-Index: 3
#2Jinhai Pan (Sichuan University)H-Index: 1
Last. Xin Zhou (Sichuan University)H-Index: 6
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Dental follicle cells (DFCs) are a group of mesenchymal progenitor cells surrounding the tooth germ, responsible for cementum, periodontal ligament, and alveolar bone formation in tooth development. Cascades of signaling pathways and transcriptional factors in DFCs are involved in directing tooth eruption and tooth root morphogenesis. Substantial researches have been made to decipher multiple aspects of DFCs, including multilineage differentiation, senescence, and immunomodulatory ability. DFCs ...
20 CitationsSource
#1Ruoshi Xu (Sichuan University)H-Index: 6
#2Daimo Guo (Sichuan University)H-Index: 1
Last. Liwei Zheng (Sichuan University)H-Index: 17
view all 10 authors...
Bone remodelling keeps going through the lifespan of human by bone formation and bone resorption. In the craniofacial region, mandibles act as the main force for biting and chewing, and also become susceptible to a common bone-loss disease, namely, apical periodontitis, once infected dental pulp is not treated timely, during which bone resorption occurs from the apical foramen to the apical bone area. Although conventional root canal treatment (RCT) can remove the most of the infection, chronica...
4 CitationsSource
#1Si Wu (Sichuan University)H-Index: 3
#2Jun Zhang (Sichuan University)H-Index: 3
Last. Yachuan Zhou (Sichuan University)H-Index: 9
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Beyond energy production, nutrient metabolism plays a crucial role in stem cell lineage determination. Changes in metabolism based on nutrient availability and dietary habits impact stem cell identity. Evidence suggests a strong link between metabolism and epigenetic mechanisms occurring during embryonic development and later life of offspring. Metabolism regulates epigenetic mechanisms such as modifications of DNA, histones, and microRNAs. In turn, these epigenetic mechanisms regulate metabolic...
8 CitationsSource
#1Yi Fan (Sichuan University)H-Index: 6
#2Yachuan Zhou (Sichuan University)H-Index: 9
Last. Liwei Zheng (Sichuan University)H-Index: 17
view all 12 authors...
Enamel mineralization is accompanied by the release of protons into the extracellular matrix, which is buffered to regulate the pH value in the local microenvironment. The present study aimed to investigate the role of microRNA 224 (miR-224) as a regulator of SLC4A4 and CFTR, encoding the key buffering ion transporters, in modulating enamel mineralization. miR-224 was significantly downregulated as ameloblasts differentiated, in parallel with upregulation of SLC4A4 and CFTR. Overexpression of mi...
14 CitationsSource
#1Kunneng LiangH-Index: 15
#2He YuanH-Index: 8
Last. Jiyao LiH-Index: 33
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The remineralization of demineralized dentin with biomimetic templates is of great interest in the fields of material science and stomatology. Amine-terminated PAMAM dendrimer (PAMAM-NH2), which possesses a highly ordered architecture and many calcium coordination sites, may be a desirable template for inducing dentin remineralization. In this study, the remineralization effect of the third generation PAMAM-NH2 (G3-PAMAM-NH2) on demineralized dentin is investigated. Demineralized dentin samples ...
31 CitationsSource