Meng Zhang
Jilin University
GeneMessenger RNAAdipogenesismicroRNAGene expressionTranscriptomeAdipose tissuePeroxisome proliferator-activated receptorDNA methylationN6-MethyladenosineAdipocyteIntramuscular fatFusariumMethylationEpigeneticsCladeProteomicsPolymerase chain reactionSelective sweepGeneticsCompeting endogenous RNALong non-coding RNASignal transductionRNACandidate geneReprogrammingBiologyEmbryogenesisDNA microarrayCell biology
39Publications
9H-index
213Citations
Publications 23
Newest
#1Yanhui Zhai (JLU: Jilin University)H-Index: 5
#2Meng Zhang (JLU: Jilin University)H-Index: 9
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
view all 9 authors...
Pre-implantation embryos undergo genome-wide DNA demethylation, however certain regions, like imprinted loci remain methylated. However, the mechanisms ensuring demethylation resistance by TRIM28 in epigenetic reprogramming remain poorly understood. Here, TRIM28 was knocked down in oocytes, and its effects on porcine somatic cell nuclear transfer (SCNT) embryo development was examined. Our results showed that SCNT embryos constructed from Trim28 knockdown oocytes had significantly lower cleavage...
Source
#1Meng Zhang (JLU: Jilin University)H-Index: 9
#2Yanhui Zhai (JLU: Jilin University)H-Index: 5
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
view all 5 authors...
Source
#1Meng ZhangH-Index: 9
#2Sheng ZhangH-Index: 9
Last. Ziyi LiH-Index: 14
view all 8 authors...
Source
#1Meng Zhang (JLU: Jilin University)H-Index: 9
#2Han Y (JLU: Jilin University)H-Index: 1
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
view all 7 authors...
Tissue-specific fat deposition is regulated by a series of complex regulatory mechanisms. Reports indicate that epigenetic regulators, such as circular RNAs (circRNAs), are crucial in diseases progression, animal development, metabolism, and adipogenesis. In this study, to assess the functional roles of circRNAs in adipogenesis and tissue-specific fat deposition, we comprehensively analyzed the Ribo-Zero RNA-Seq and miRNAs data during chicken intramuscular and abdominal adipogenic differentiatio...
3 CitationsSource
#1Meng Zhang (JLU: Jilin University)H-Index: 9
#2Yanhui Zhai (JLU: Jilin University)H-Index: 5
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
view all 5 authors...
N6-methyladenosine (m6A) is one of the most abundant internal mRNA modifications, and it affects multiple biological processes related to eukaryotic mRNA. The majority of m6A sites are located in stop codons and 3'UTR regions of mRNAs. m6A regulates RNA metabolism, including alternative splicing (AS), alternative polyadenylation (APA), mRNA export, decay, stabilization, and translation. The m6A metabolic pathway is regulated by a series of m6A writers, erasers and readers. Recent studies indicat...
5 CitationsSource
#1Donghua Li (Henan Agricultural University)H-Index: 9
#2Guirong Sun (Henan Agricultural University)H-Index: 17
Last. Xiangtao Kang (Henan Agricultural University)H-Index: 15
view all 16 authors...
Domesticated chickens have a wide variety of phenotypes, in contrast with their wild progenitors. Unlike other chicken breeds, Xichuan black-bone chickens have blue-shelled eggs, and black meat, beaks, skin, bones, and legs. The breeding history and the economically important traits of this breed have not yet been explored at the genomic level. We therefore used whole genome resequencing to analyze the breeding history of the Xichuan black-bone chickens and to identify genes responsible for its ...
3 CitationsSource
view all 16 authors...
Source
#1Meng Zhang (Henan Agricultural University)H-Index: 9
#2Donghua Li (Henan Agricultural University)H-Index: 9
Last. Guirong Sun (Henan Agricultural University)H-Index: 17
view all 12 authors...
Intramuscular fat (IMF), which regulated by genetics, nutrition and environment is an important factor that influencing meat quality. Up to now, the epigenetic regulation mechanism underlying poultry IMF deposition remains poorly understood. Here, we focused on the DNA methylation, which usually regulate genes in transcription level. To look into the essential role of DNA methylation on the IMF deposition, chicken intramuscular preadipocytes were isolated and cultured in vitro, and a model of in...
2 CitationsSource
#1Meng Zhang (Henan Agricultural University)H-Index: 9
#2Xiangfei Ma (Henan Agricultural University)H-Index: 4
Last. Guirong Sun (Henan Agricultural University)H-Index: 17
view all 14 authors...
Adipose tissue-specific distribution and deposition speed are the main factors affecting the slaughter performance and meat quality in poultry. Previous studies suggested that different adipose tissues owned various biochemical characteristics and gene expression patterns. To investigate the functional role of long noncoding RNAs (lncRNAs) during chicken intramuscular and abdominal adipogenesis, we performed transcriptome analysis by Ribo-Zero RNA-Seq technology. A total of 11247 lncRNAs were ob...
2 CitationsSource
#1Jia Liu (Henan Agricultural University)H-Index: 7
#2Shichao Lu (Henan Agricultural University)H-Index: 1
Last. Qing X. Li (U.H.: University of Hawaii at Manoa)H-Index: 41
view all 11 authors...
Fungal pathogens cause serious crop diseases and decrease crop yields and quality. Polyacetylene alcohols are plant secondary metabolites and bioactive against various pathogenic fungi. They are, however, difficult to synthesize. In the present study, an efficient and highly enantioselective method (> 98% ee) was established and employed to achieve the natural C18 polyacetylenes (S, E)-octadeca-1,9-dien-4,6-diyn-3-ol 1, (3R, 10R, E)-octadeca-1,8-dien-4,6-diyne-3,10-diol 2 and their analogs. The ...
Source