Simona Panelli
University of Milan
GeneInternal medicineEcologyImmunologyRibosomal Intergenic Spacer analysisRaw milkKlebsiella pneumoniaeDysbiosisMycobiotaTypingFood scienceHigh Resolution MeltComputer scienceGut floraGeneticsComputational biologyMedicineMultilocus sequence typingBiologyImmune systemGastroenterology
35Publications
9H-index
192Citations
Publications 34
Newest
#1Matteo Perini (University of Milan)H-Index: 4
#2Aurora Piazza (UNIPV: University of Pavia)H-Index: 11
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Objectives Subspecies pathogen typing is a pivotal tool to detect the emergence of high-risk clones null in hospital settings and to limit their spreading among patients. Unfortunately, the most used subspecies typing methods (i.e. Pulsed-field Gel Electrophoresis - PFGE, Multi-Locus Sequence Typing - MLST and Whole Genome Sequencing - WGS) are too expensive and time consuming to be suitable for real-time surveillance. Here we present Hypervariable-Locus Melting Typing (HLMT), a novel subspecies...
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#1Annalisa Schiepatti (UNIPV: University of Pavia)H-Index: 8
#2Sara Bacchi (UNIPV: University of Pavia)H-Index: 2
Last. Rachele Ciccocioppo (University of Verona)H-Index: 30
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Abstract Background Duodenal dysbiosis has been suggested to possibly influence the clinical manifestations of coeliac disease (CD), both at onset and when symptoms persist despite a gluten-free diet (GFD). AIMS To evaluate the relationship between duodenal microbiota composition and: i) clinical phenotype of untreated CD (UCD); ii) presence and type of persistent symptoms despite a satisfactory serological and histological response to a strict GFD. Methods Duodenal microbiota was analyzed by 16...
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#1Lucia Cococcioni (University of Milan)H-Index: 3
#2Simona Panelli (University of Milan)H-Index: 9
Last. Francesco Comandatore (University of Milan)H-Index: 14
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Abstract Inflammatory Bowel Diseases (IBDs) are gastrointestinal disorders characterized by chronic, relapsing inflammation, with growing incidence worldwide over the last decades and distinctive features in the pediatric age. An increasing body of evidence indicates that gut microbiota plays a major role in inflammatory disorders, including IBDs. In this review we will discuss the most recent evidences on dysbiotic changes associated with gut inflammation, as well as environmental and genetic f...
1 CitationsSource
Last. Simona PanelliH-Index: 9
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#1Enza D'Auria (Boston Children's Hospital)H-Index: 16
#2Simona Panelli (University of Milan)H-Index: 9
Last. Gian Vincenzo Zuccotti (Boston Children's Hospital)H-Index: 55
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To assess the effect of a fermented rice-flour obtained from Lactobacillus paracasei CBA L74 in managing infants with moderate to severe atopic dermatitis. Infants with moderate to severe atopic dermatitis, aged 6-36 months, were randomly assigned to receive once-daily consumption of rice flour containing heat-killed probiotic Lactobacillus paracasei CBA L74 or placebo for 12 weeks as supplementary approach to topical treatment. Primary outcome was SCORAD index change from baseline to 12 weeks; ...
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#1Simona Panelli (University of Milan)H-Index: 9
#2Marta CorbellaH-Index: 8
Last. Patrizia CambieriH-Index: 5
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The establishment of gut microbiota is reportedly aberrant in newborns admitted to neonatal intensive care units (NICUs), with detrimental long-term health impacts. Here, we vertically tracked the developing gut bacterial communities of newborns hosted in an NICU during an outbreak sustained by ESBL Klebsiella pneumoniae and compared colonized and non-colonized patients. Most communities were highly variable from one sampling point to the next, and dominated by few taxa, often Proteobacteria and...
#1Alessandra GazzolaH-Index: 1
#2Simona PanelliH-Index: 9
Last. Patrizia CambieriH-Index: 5
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Clostridioides difficile infection (CDI) is the leading cause of antibiotic-associated diarrhea, especially in hospitalized elderly patients, representing a global public health concern. Clinical presentations vary from mild diarrhea to severe pseudomembranous colitis that may progress to toxic megacolon or intestinal perforation. Antibiotic therapy is recognized as a risk factor and exacerbates dysbiosis of the intestinal microbiota, whose role in CDI is increasingly acknowledged. A clinically ...
2 CitationsSource
#1Simona Panelli (University of Milan)H-Index: 9
#2Sara Epis (University of Milan)H-Index: 26
Last. Gian Vincenzo Zuccotti (University of Milan)H-Index: 55
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Abstract This review tackles the concept of the evolutionary mismatch, in relation with the reduction of the prevalence of the so-called “dirty old friends”. These formed the variegated community of parasites and microorganisms, either prokaryotic or eukaryotic, that, over long evolutionary times, co-evolved with humans and their ancestors, inhabiting their digestive tracts, and other body districts. This community of microbial symbionts and metazoan parasites is thought to have evolved a comple...
1 CitationsSource
#1Matteo Perini (University of Milan)H-Index: 4
#2Gherard Batisti Biffignandi (UNIPV: University of Pavia)H-Index: 3
Last. Francesco Comandatore (University of Milan)H-Index: 14
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MeltingPlot is an open source web tool for pathogen typing and epidemiological investigations using High Resolution Melting (HRM) data. The tool implements a graph-based algorithm designed to discriminate pathogen clones on the basis of HRM data, producing portable typing results. MeltingPlot also merges typing information with isolates and patients metadata to create graphical and tabular outputs useful in epidemiological studies. HRM technique allows pathogen typing in less than 5 hours with ~...
2 CitationsSource
#1Simona Panelli (University of Milan)H-Index: 9
#2Enrica Capelli (UNIPV: University of Pavia)H-Index: 16
Last. Rachele Ciccocioppo (University of Verona)H-Index: 30
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Background: Growing evidence suggests that an altered microbiota composition contributes to the pathogenesis and clinical features in celiac disease (CD). We performed a comparative analysis of the gut microbiota in adulthood CD to evaluate whether: (i) dysbiosis anticipates mucosal lesions, (ii) gluten-free diet restores eubiosis, (iii) refractory CD has a peculiar microbial signature, and (iv) salivary and fecal communities overlap the mucosal one. Methods: This is a cross-sectional study wher...
7 CitationsSource