P.C. de Jong
MCF-7Internal medicineEndocrinologyCellGene expressionEndogenyEnzymeChemistryIn vivoHormone receptorGREB1AromataseNaringeninEstrogenGenisteinApigeninBiochanin AUterusFadrozoleParabenChrysinCosmeticsEndometriumSteroidEstrogen receptor bindingTherapeutic EstrogenAryl hydrocarbon receptorCytochrome P450BiochemistryHormoneEstrogen receptorBiologyMicrosomePharmacology
5Publications
4H-index
148Citations
Publications 5
Newest
#1A.D. van den Brand (UU: Utrecht University)H-Index: 2
#2E. RubinsteinH-Index: 2
Last. Mbm van Duursen (VU: VU University Amsterdam)H-Index: 1
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Abstract Unopposed estrogenic action in the uterus can lead to the development of endometrial cancer in both humans and rats. Aryl hydrocarbon receptor (AHR) activation gives rise to anti-estrogenic actions and may consequently reduce the development of endometrial cancer. In this study, the anti-estrogenic potential of the AHR ligands 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and DELAQ, a metabolite of the pharmaceutical laquinimod, was assessed in in primary human and rat endometrial epitheli...
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#1A.D. van den Brand (UU: Utrecht University)H-Index: 2
#2E. RubinsteinH-Index: 2
Last. M.B.M. van Duursen (VU: VU University Amsterdam)H-Index: 2
view all 5 authors...
Abstract Human and rat reproductive systems differ significantly with respect to hormonal cyclicity and endometrial cell behavior. However, species-differences in endometrial cell responses upon hormonal stimulation and exposure to potentially toxic compounds are poorly characterized. In this study, human and rat endometrial hormonal responses were assessed in vitro using a 3D co-culture model of primary human and rat endometrial cells. The models were exposed to the aryl hydrocarbon receptor (A...
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#1J.A. van Meeuwen (UU: Utrecht University)H-Index: 6
#2O. van Son (UU: Utrecht University)H-Index: 1
Last. M. van den Berg (UU: Utrecht University)H-Index: 37
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There is concern widely on the increase in human exposure to exogenous (anti)estrogenic compounds. Typical are certain ingredients in cosmetic consumer products such as musks, phthalates and parabens. Monitoring a variety of human samples revealed that these ingredients, including the ones that generally are considered to undergo rapid metabolism, are present at low levels. In this in vitro research individual compounds and combinations of parabens and endogenous estradiol (E{sub 2}) were invest...
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#1J.A. van Meeuwen (UU: Utrecht University)H-Index: 6
#2S. M. Nijmeijer (UU: Utrecht University)H-Index: 20
Last. M. van den Berg (UU: Utrecht University)H-Index: 37
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Interference of exogenous chemicals with the aromatase enzyme can be useful as a tool to identify chemicals that could act either chemopreventive for hormone-dependent cancer or adverse endocrine disruptive. Aromatase is the key enzyme in the biosynthesis of steroids, as it converts androgens to estrogens. Certain flavonoids, plant derived chemicals, are known catalytic aromatase inhibitors. Various systems are in use to test aromatase inhibitory properties of compounds. Commonly used are micros...
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#1J.A. van Meeuwen (UU: Utrecht University)H-Index: 6
#2Nicoline M. Korthagen (UU: Utrecht University)H-Index: 14
Last. M. van den Berg (UU: Utrecht University)H-Index: 37
view all 5 authors...
Abstract In the public opinion, phytochemicals (PCs) present in the human diet are often considered beneficial (e.g. by preventing breast cancer). Two possible mechanisms that could modulate tumor growth are via interaction with the estrogen receptor (ER) and inhibition of aromatase (CYP19). Multiple in vitro studies confirmed that these compounds act estrogenic, thus potentially induce tumor growth, as well as aromatase inhibitory, thus potentially reduce tumor growth. It is thought that in the...
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