Stefanie Thust
UCL Institute of Neurology
Fluid-attenuated inversion recoveryIntraclass correlationPercentileRadiologyMagnetic resonance imagingConcordanceMedical physicsGlioblastomaGliomaProgressive diseaseNeuroradiologyDifferential diagnosisNuclear medicineSaturation transferChemical exchangeGenotypingCancer researchGadoliniumEffective diffusion coefficientMedicineArea under the curve
22Publications
7H-index
231Citations
Publications 20
Newest
#1Arian Lasocki (Peter MacCallum Cancer Centre)H-Index: 11
#2Mustafa AnjariH-Index: 7
Last. Stefanie Thust (UCL Institute of Neurology)H-Index: 7
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Molecular parameters have become integral to glioma diagnosis. Much of radiogenomics research has focused on the use of advanced MRI techniques, but conventional MRI sequences remain the mainstay of clinical assessments. The aim of this research was to synthesize the current published data on the accuracy of standard clinical MRI for diffuse glioma genotyping, specifically targeting IDH and 1p19q status. A systematic search was performed in September 2019 using PubMed and the Cochrane Library, i...
2 CitationsSource
#1S.C. Thust (UCL Institute of Neurology)
#1Stefanie Thust (UCL Institute of Neurology)H-Index: 7
Last. Hans Rolf Jäger (UCL Institute of Neurology)H-Index: 47
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BACKGROUND AND PURPOSE Studies consistently report lower ADC values in isocitrate dehydrogenase (IDH) wild-type gliomas than in IDH mutant tumors, but their methods and thresholds vary. This research aimed to compare volumetric and regional ADC measurement techniques for glioma genotyping, with a focus on IDH status prediction. MATERIALS AND METHODS Treatment-naive World Health Organization grade II and III gliomas were analyzed by 3 neuroradiologist readers blinded to tissue results. ADC minimu...
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Background To assess anatomical and quantitative diffusion-weighted MR imaging features in a recently classified lethal neoplasm, H3 K27M histone-mutant diffuse midline glioma [World Health Organization (WHO) IV]. Methods Fifteen untreated gliomas in teenagers and adults (median age 19, range, 14-64) with confirmed H3 K27M histone-mutant genotype were analysed at a national referral centre. Morphological characteristics including tumour epicentre(s), T2/FLAIR and Gadolinium enhancement patterns,...
2 CitationsSource
#1John MaynardH-Index: 3
#1John MaynardH-Index: 1
Last. Stefanie ThustH-Index: 7
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Background A readily implemented MRI biomarker for glioma genotyping is currently lacking. Purpose To evaluate clinically available MRI parameters for predicting isocitrate dehydrogenase (IDH) status in patients with glioma. Materials and Methods In this retrospective study of patients studied from July 2008 to February 2019, untreated World Health Organization (WHO) grade II/III gliomas were analyzed by three neuroradiologists blinded to tissue results. Apparent diffusion coefficient (ADC) mini...
10 CitationsSource
#1Mairéad G McNamaraH-Index: 26
#2S BrandnerH-Index: 6
Last. Stefanie ThustH-Index: 7
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#1Sachi Okuchi (UCL: University College London)H-Index: 1
#1Sachi OkuchiH-Index: 3
Last. Stefanie C. ThustH-Index: 1
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Chemical exchange saturation transfer can be further developed as a biomarker for metabolically active brain tumors, evidenced by correlations to tissue findings, including proliferative indexes; f...
1 CitationsSource
#1Mairéad G McNamaraH-Index: 26
#2S BrandnerH-Index: 6
Last. Stefanie ThustH-Index: 7
view all 3 authors...
#1Mina Kim (UCL: University College London)H-Index: 3
#2F Torrealdea (UCLH: University College Hospital)H-Index: 1
Last. Xavier GolayH-Index: 60
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Background: The aim of this study was to translate dynamic glucose enhancement (DGE) body magnetic resonance imaging (MRI) based on the glucose chemical exchange saturation transfer (glucoCEST) signal to a 3 T clinical field strength. Methods: An infusion protocol for intravenous (i.v.) glucose was optimised using a hyperglycaemic clamp to maximise the chances of detecting exchange-sensitive MRI signal. Numerical simulations were performed to define the optimum parameters for glucoCEST measureme...
8 CitationsSource
#1Sachi Okuchi (UCL: University College London)H-Index: 3
#1Sachi Okuchi (UCL: University College London)H-Index: 1
Last. Sotirios Bisdas (UCL: University College London)H-Index: 40
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Background T1‐weighted dynamic contrast‐enhanced (DCE) perfusion magnetic resonance imaging (MRI) has been broadly utilized in the evaluation of brain tumors. We aimed at assessing the diagnostic accuracy of DCE‐MRI in discriminating between low‐grade gliomas (LGGs) and high‐grade gliomas (HGGs), between tumor recurrence and treatment‐related changes, and between primary central nervous system lymphomas (PCNSLs) and HGGs. Methods We performed this study based on the Preferred Reporting Items for...
6 CitationsSource
#1Harpreet Hyare (UCL Institute of Neurology)H-Index: 3
#1Harpreet Hyare (UCL Institute of Neurology)H-Index: 6
Last. Jeremy Rees (UCL Institute of Neurology)H-Index: 31
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Abstract Background and purpose There is increasing evidence that many IDH wildtype (IDHwt) astrocytomas have a poor prognosis and although MR features have been identified, there remains diagnostic uncertainty in the clinic. We have therefore conducted a comprehensive analysis of conventional MR features of IDHwt astrocytomas and performed a Bayesian logistic regression model to identify critical radiological and basic clinical features that can predict IDH mutation status. Materials and method...
6 CitationsSource