Ignacio N. Retamal
University of Los Andes
CancerInternal medicinePathologyOncologyLatin AmericansMortality rateTissue microarrayImmunohistochemistryMyofibroblastGiSTImmunotherapyMethylglyoxalDiseaseMEDLINEAngiogenesisKRASMolecular classificationPeriodontal diseasePeriodontal tissueIncidence (epidemiology)Connective tissueViability assayDiabetes mellitusMedicineCohortBiologyGastroenterology
24Publications
6H-index
101Citations
Publications 21
Newest
#1Diego Prieto (University of Los Andes)H-Index: 2
#2Camila González (University of Los Andes)H-Index: 13
Last. Alejandra Chaparro (University of Los Andes)H-Index: 13
view all 11 authors...
Abstract Background To explore the soluble Neuropilin-1 (sNRP-1) concentrations in gingival crevicular fluid (GCF) and the periodontal clinical status of patients with Rheumatoid Arthritis (RA). Materials and methods We conducted an exploratory study with 40 study participants, 20 with RA, and 20 healthy controls. Clinical and periodontal data were recorded, and GCF samples were obtained. sNRP-1 levels in GCF were determined by ELISA assay. Descriptive statistics, Mann–Whitney U test, Unpaired t...
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#1Doris DuránH-Index: 2
#2Ignacio Retamal (San Sebastián University)
Last. María José MonsalvesH-Index: 5
view all 4 authors...
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#1Mauricio P. PintoH-Index: 11
Last. Marcelo GarridoH-Index: 21
view all 8 authors...
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#1Mauricio P. Pinto (UC: Pontifical Catholic University of Chile)H-Index: 11
#2Miguel Cordova-Delgado (UC: Pontifical Catholic University of Chile)H-Index: 6
Last. Marcelo Garrido (UC: Pontifical Catholic University of Chile)H-Index: 21
view all 18 authors...
Gastric cancer (GC) is a complex and heterogeneous disease. In recent decades, The Cancer Genome Atlas (TCGA) and the Asian Cancer Research Group (ACRG) defined GC molecular subtypes. Unfortunately, these systems require high-cost and complex techniques and consequently their impact in the clinic has remained limited. Additionally, most of these studies are based on European, Asian, or North American GC cohorts. Herein, we report a molecular classification of Chilean GC patients into five subtyp...
5 CitationsSource
#1Camila Foncea (UC: Pontifical Catholic University of Chile)H-Index: 2
#2Kristine von Bischhoffshausen (UC: Pontifical Catholic University of Chile)
Last. Alex Vargas (UC: Pontifical Catholic University of Chile)H-Index: 7
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Medication-related osteonecrosis of the jaw is a disease where there is necrotic bone exposed or that can be explored by means of a fistula in the maxillofacial region. It has been associated with the use Biphosphonates and denosumab for osteoporosis. Although its etiology is unclear, it may be related to a decrease in bone turnover produced by these drugs, rendering the bone more prone to generate cell necrosis during invasive dental procedures, especially in the posterior region of the jaw. Th...
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#2Matías Muñoz-Medel (UC: Pontifical Catholic University of Chile)H-Index: 2
Last. Marcelo Garrido (UC: Pontifical Catholic University of Chile)H-Index: 21
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PURPOSELike other malignancies, GI stromal tumors (GIST) are highly heterogeneous. This not only applies to histologic features and malignant potential, but also to geographic incidence rates. Seve...
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#1Ignacio N. Retamal (University of Los Andes)H-Index: 6
#1Ignacio N Retamal (University of Los Andes)H-Index: 1
Last. Patricio C. Smith (UC: Pontifical Catholic University of Chile)H-Index: 22
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OBJECTIVES: Myofibroblasts constitute a specific cell phenotype involved in connective tissue healing. Diabetes alters the wound healing response. However, it is not clear whether diabetes modifies the involvement of myofibroblasts in periodontal wounds. MATERIAL AND METHODS: Type I diabetes was induced in rats through streptozotocin injection and periodontal wounds were performed. Wound healing was evaluated histologically at 2, 5, 7 and 15 days by measuring epithelial migration, neutrophil inf...
3 CitationsSource
#1Miguel Cordova-Delgado (University of Chile)H-Index: 6
#2Mauricio P. Pinto (UC: Pontifical Catholic University of Chile)H-Index: 11
Last. Marcelo GarridoH-Index: 21
view all 37 authors...
Gastric cancer (GC) is a heterogeneous disease. This heterogeneity applies not only to morphological and phenotypic features but also to geographical variations in incidence and mortality rates. As Chile has one of the highest mortality rates within South America, we sought to define a molecular profile of Chilean GCs (ClinicalTrials.gov identifier: NCT03158571/(FORCE1)). Solid tumor samples and clinical data were obtained from 224 patients, with subsets analyzed by tissue microarray (TMA; n = 9...
13 CitationsSource
#1Mauricio P. Pinto (UC: Pontifical Catholic University of Chile)H-Index: 11
#2Ignacio N. Retamal (UC: Pontifical Catholic University of Chile)H-Index: 6
Last. Marcelo Garrido (UC: Pontifical Catholic University of Chile)H-Index: 21
view all 22 authors...
Background: Globally, gastric cancer (GC) ranks as the third cause of cancer related mortality. Like most malignancies, GC is characterized by its heterogeneity. In Chile, GC is the leading cause of cancer death claiming >3,000 deaths/year. Given its high heterogeneity an effective GC patient stratification may improve clinical outcomes. Here, we describe the results of the Chilean Gastric Cancer Task Force (GCTF) a descriptive cross sectional study (ClinicalTrials.gov identifier: NCT03158571, r...
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#1Mauricio P. Pinto (UC: Pontifical Catholic University of Chile)H-Index: 11
#2Matias Munoz Medel (UC: Pontifical Catholic University of Chile)H-Index: 2
Last. Marcelo Garrido (UC: Pontifical Catholic University of Chile)H-Index: 21
view all 25 authors...
Neuroendocrine tumors (NETs) are relatively rare and highly heterogeneous neoplasms. Despite this, recent studies from North America and Central Europe have suggested an increase in incidence. In Latin America, NET data are scarce and scattered with only a few studies reporting registries. Our goal was to establish a NET registry in Chile. Here, we report the establishment and our first 166 NET patients. We observed a slight preponderance of males, a median age at diagnosis of 53 years and a med...
7 CitationsSource