Hang Lin
Chinese Academy of Sciences
Self-healing hydrogelsAnalytical chemistryBiomedical engineeringLuminescenceRegeneration (biology)NanocrystalChemistryExtracellular matrixMaterials scienceMesenchymal stem cellOsteoarthritisCartilageStem cellBone morphogenetic protein 2ChondrogenesisTissue engineeringMedicineBone healingScaffoldCell biology
112Publications
36H-index
3,495Citations
Publications 115
Newest
#1Li Cheng (CAS: Chinese Academy of Sciences)
#2Yao Cheng (CAS: Chinese Academy of Sciences)H-Index: 26
Last. Yuansheng Wang (CAS: Chinese Academy of Sciences)H-Index: 68
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Abstract Taking advantage of multi-photon absorption, the semiconductor quantum dots show great potential in the field of bio-logical fluorescence imaging. In this paper, PbS/CdS core-shell quantum dots with the band alignment adjustable from type-I to quasi-type II are prepared through the cation exchange method. The core-shell quantum dots exhibit bright broad-band visible/near-infrared upconversion emission upon the excitation of 1064 nm pulse laser, and the core-shell QDs hold a decay lifeti...
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#1Shisheng Lin (CAS: Chinese Academy of Sciences)H-Index: 4
#2Hang Lin (CAS: Chinese Academy of Sciences)H-Index: 36
Last. Yuansheng Wang (CAS: Chinese Academy of Sciences)H-Index: 68
view all 9 authors...
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#1Jamie K. Moy (University of Pittsburgh)H-Index: 13
#2Zhong Li (University of Pittsburgh)H-Index: 25
Last. Michael S. Gold (University of Pittsburgh)H-Index: 53
view all 12 authors...
The development of safe and effective methods for the treatment of osteoarthritis(OA)-associated pain is a critical need. Recently, our team successfully modeled OA-like pathology in an in vitro multi-component joint-on-a-chip (microJoint), which integrates engineered osteochondral complex, synovium, adipose tissue and given their crucial role in joint pain, macrophages. In the present project, we introduce the sensory neurons into the established microJoint to generate the neu-microJoint, enabl...
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#1Qi GaoH-Index: 5
#2Claire RheeH-Index: 2
Last. Stuart B. GoodmanH-Index: 93
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Wear debris generated from the bearing surfaces of joint arthroplasties leads to acute and chronic inflammation, which is strongly associated with implant failure. Macrophages derived from monocytes recruited to the local tissues have a significant impact on bone healing and regeneration. Macrophages can adopt various functional phenotypes. While M1 macrophages are pro-inflammatory, M2 macrophages express factors important for tissue repair. Here, we established a 3D co-culture system to investi...
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#1Ning Wang (University of Pittsburgh)
#2Yuchen He (University of Pittsburgh)H-Index: 1
Last. Hang Lin (University of Pittsburgh)H-Index: 36
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Significant cellular senescence has been observed in cartilage harvested from patients with osteoarthritis (OA). In this study, we aim to develop a senescence-relevant OA cartilage model for developing disease-modifying OA drugs (DMOADs). Specifically, human bone marrow-derived mesenchymal stromal cells (MSCs) were expanded in vitro up to passage 10 (P10-MSCs). Following their senescent phenotype formation, P10-MSCs were subjected to pellet culture in chondrogenic medium. Results from qRT-PCR, h...
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#1Yuzhao Huang (CSU: Central South University)
#2Yuchen He (University of Pittsburgh)H-Index: 1
Last. Hang Lin (University of Pittsburgh)H-Index: 36
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Autologous chondrocyte implantation (ACI) is a procedure used to treat articular cartilage injuries and prevent the onset of post-traumatic osteoarthritis. In vitro expansion of chondrocytes, a necessary step in ACI, results in the generation of senescent cells that adversely affect the quality and quantity of newly formed cartilage. Recently, a senolytic peptide, fork head box O transcription factor 4-D-Retro-Inverso (FOXO4-DRI), was reported to selectively kill the senescent fibroblasts. In th...
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#1Youhui ZhouH-Index: 1
#2Yao ChengH-Index: 26
Last. Yuansheng WangH-Index: 68
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Recent discoveries regarding the anomalous thermo-enhanced luminescence of upconversion nanoparticles (UCNPs) have attracted great interest because of their potentially significant technological importance. Meanwhile, the great debate about the underlying mechanism responsible for this unique luminescence thermal behavior may be equally compelling. To this point, special attention has been paid to the critical interplay between surface species and the energy transfer process (from the sensitizer...
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#1H. Iijima (University of Pittsburgh)
#1Hirotaka Iijima (University of Pittsburgh)H-Index: 1
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Enhanced mechanistic insight into age-related knee osteoarthritis (KOA) is an essential step to promote successful translation of animal research to bedside interventions. To this end, the goal of these studies was to interrogate molecular mechanisms driving age-related KOA in a mouse model and correspond findings to human knee cartilage. Unbiased mass spectrometry proteomics of cartilage tissue revealed PI3K/Akt signaling was the predominant pathway disrupted over time in male, but not female, ...
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#1He Shen (University of Pittsburgh)H-Index: 28
#1He Shen (University of Pittsburgh)H-Index: 6
Last. Rocky S. Tuan (University of Pittsburgh)H-Index: 122
view all 7 authors...
Autologous chondrocyte implantation (ACI) is a regenerative procedure used to treat focal articular cartilage defects in knee joints. However, age has been considered as a limiting factor and ACI is not recommended for patients older than 40-50 years of age. One reason for this may be due to the reduced capacity of aged chondrocytes in generating new cartilage. Currently, the underlying mechanism contributing to aging-associated functional decline in chondrocytes is not clear and no proven appro...
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#1Youhui ZhouH-Index: 1
#2Yao ChengH-Index: 26
Last. Yuansheng WangH-Index: 68
view all 6 authors...
Luminescent materials usually suffer from luminescence thermal quenching because of the aggravation of various nonradiation relaxations with elevated temperatures. However, recent discovery on the abnormal thermally enhanced upconversion luminescence has triggered extensive attention. Although considerable efforts have been spent exploring the underlying mechanism, significant disagreements remain for different proposed mechanisms. In this mini-review, we have briefly summarized recent progress ...
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