Rebecca B. Wates
University of Kansas
FrizzledCancerAutocrine signallingWnt signaling pathwayMatrix (biology)LRP6MechanotransductionLRP5Peritoneal cavityMetastasisAbdominal distensionMechanobiologyOvarian cancerAscitesCancer researchMedicineBiologyCell biologyCancer cell
Publications 3
#1Yuliya Klymenko (ND: University of Notre Dame)H-Index: 8
#2Rebecca B. Wates (KU: University of Kansas)H-Index: 2
Last. M. Sharon Stack (ND: University of Notre Dame)H-Index: 17
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ABSTRACT Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy. EOC dissemination is predominantly via direct extension of cells and multicellular aggregates (MCAs) into the peritoneal cavity, which adhere to and induce retraction of peritoneal mesothelium and proliferate in the submesothelial matrix to generate metastatic lesions. Metastasis is facilitated by the accumulation of malignant ascites (500 ml to >2 l), resulting in physical discomfort and abdominal distension, ...
9 CitationsSource
#1Yuliya KlymenkoH-Index: 8
#2Rebecca B. WatesH-Index: 2
Last. M. Sharon StackH-Index: 59
view all 9 authors...
#1Marwa Asem (ND: University of Notre Dame)H-Index: 5
#2Steven Buechler (ND: University of Notre Dame)H-Index: 11
Last. M. Stack (ND: University of Notre Dame)H-Index: 3
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Wnt5a is involved in activating several non-canonical WNT signaling pathways, through binding to different members of the Frizzled- and Ror-family receptors. Wnt5a signaling is critical for regulating normal developmental processes, including proliferation, differentiation, migration, adhesion and polarity. However, the aberrant activation or inhibition of Wnt5a signaling is emerging as an important event in cancer progression, exerting both oncogenic and tumor suppressive effects. Recent studie...
104 CitationsSource