Hua Nian
Shanghai University
Cell cycle checkpointAcute toxicityGene expressionMolecular biologyGene expression profilingApoptosisOsteoporosisBone mineralInflammationArthritisRheumatoid arthritisApigeninVitex negundoIcariinSpleenType II collagenCell cycleCell growthOvariectomized ratCell division
Publications 3
#1Rui Jing ('SMMU': Second Military Medical University)H-Index: 3
#2Yanfei Ban ('SMMU': Second Military Medical University)H-Index: 1
Last. Cheng-Jian Zheng ('SMMU': Second Military Medical University)H-Index: 22
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Abstract Background The seeds of Vitex negundo, with rich lignans metabolites, have been widely used as a traditional Chinese medicine and Ayurvedic herbal medicine for the treatment of rheumatism and joint inflammation. The total lignans of Vitex negundo seeds (TOV) were suggested to play an important role in the treatment of arthritis. Purpose The aim of the study was designed to investigate the anti-arthritic effects of TOV on collagen-induced arthritis (CIA) in rats as well as its possible m...
14 CitationsSource
#1Jing Cai (NCU: Nanchang University)H-Index: 2
#2Xiang-Li Zhao (SHU: Shanghai University)H-Index: 4
Last. Shu-Hui Zhang (SHU: Shanghai University)H-Index: 1
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Abstract Apigenin, a common plant flavonoid, has been shown to possess anti-tumor properties; however, the underlying molecular mechanisms are still not completely understood. In the present study, we investigated the effects of apigenin on human hepatoma Huh7 cell proliferation, cell cycle distribution, apoptosis, and colony formation in vitro, as well as on the tumorigenicity of Huh7 cells in vivo. To get more insight into the mechanism of apigenin action, we performed genome-wide expression p...
48 CitationsSource
#1Hua Nian (SHU: Shanghai University)H-Index: 3
#2M.-H. MaH-Index: 1
Last. L.-L. Xu (SHU: Shanghai University)H-Index: 1
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Abstract Icariin was evaluated for its antiosteoporotic activity in an ovariectomized rat model of osteoporosis. The rats were divided into sham and OVX groups. The OVX rats were then subdivided into five groups treated with water, nylestriol (1 mg/kg body weight, weekly, orally) or icariin (ICA) (5, 25, and 125 mg/kg body weight, daily, orally) for 12 weeks. In OVX rats, the increases of body weight, serum BGP and ALP were significantly decreased by ICA treatment. In OVX rats, atrophy of uterus...
204 CitationsSource
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