Helen Elizabeth Fowles
Hull York Medical School
Mean differenceInternal medicineSurgeryPhysical therapyFEV1/FVC ratioSomatostatinSputumSodium bicarbonateVolunteerInhalationChronic coughBlockadeCitric acidSpirometryOctreotideConfusionATP ReceptorsHypersensitivity syndromeHealthy subjectsLimits of agreementAcute effectSingle stimulusHealthy volunteersHealthy individualsCough reflexAnesthesiaRefluxClinical researchRespiratory systemPurinergic receptorPotencyMedicineCohortGastroenterologyPharmacologyReproducibility
6Publications
2H-index
46Citations
Publications 6
Newest
#1Z.L. Rai (Castle Hill Hospital)H-Index: 1
#2Helen Elizabeth Fowles (Hull York Medical School)H-Index: 2
Last. Alyn H. Morice (Castle Hill Hospital)H-Index: 42
view all 5 authors...
Abstract Introduction Citric acid has been used for over six decades to induce cough; however the mechanism of its pro-tussive effect is still not fully understood. We assessed the response to inhalation of citric acid at varying levels of acidity to determine if the pH of the solution plays a role in the induction of cough. Data was collected from both healthy volunteers and patients with chronic cough. Methods 20 chronic cough patients and 20 healthy volunteers were recruited and underwent thr...
Source
#1Helen Elizabeth Fowles (Hull York Medical School)H-Index: 2
#2Tim Rowland (Castle Hill Hospital)H-Index: 1
Last. Alyn H. Morice (Hull York Medical School)H-Index: 42
view all 4 authors...
Cough hypersensitivity is a mystery that continues to require unravelling http://ow.ly/Fhel30cgA5u
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#1Helen Elizabeth Fowles (Hull York Medical School)H-Index: 2
#2Tim Rowland (Castle Hill Hospital)H-Index: 1
Last. Alyn H. Morice (Hull York Medical School)H-Index: 42
view all 4 authors...
Recent studies have demonstrated that blockade of P2X3 adenosine triphosphate (ATP) receptors may profoundly inhibit chronic cough. We have considered whether inhaled ATP produces a tussive response and whether chronic cough patients are hypersensitive to inhaled ATP compared to healthy volunteers. A standardised inhalational cough challenge was performed with ATP and adenosine monophosphate (AMP). 20 healthy volunteers and 20 chronic cough patients were randomised as to the order of challenges....
Source
#1L Douglas (Hull and East Yorkshire Hospitals NHS Trust)H-Index: 1
#2Helen Elizabeth Fowles (Hull York Medical School)H-Index: 2
Last. Alyn H. Morice (Hull York Medical School)H-Index: 42
view all 5 authors...
Background Cough challenges are utilised in clinical research to help determine efficacy of treatments for cough. Recently adenosine triphosphate (ATP) has gained interest as a potential tussive agent. Previous research suggests such challenges are reproducible in healthy individuals, but little is known about their reproducibility in chronic cough patients, particularly the use of ATP as a tussive agent. This study aims to clarify if ATP is a reproducible tussive agent in chronic cough patients...
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Last. Alyn H. MoriceH-Index: 42
view all 4 authors...
Introduction Citric acid has been used for over 6 decades in cough challenge studies, however despite this, the mechanism of its tussive effect is still not fully understood. We assessed the cough response to citric acid solutions, at different levels of acidity (pH) to determine what role this plays in the induction of cough. Healthy volunteers and chronic cough patients were compared. Methods 20 chronic cough patients and 20 healthy volunteers were recruited and underwent three cough challenge...
Source
#1Helen Elizabeth Fowles (Hull York Medical School)H-Index: 2
#2Alyn H. Morice (Hull York Medical School)H-Index: 42
Last. Kayleigh Arnell (Castle Hill Hospital)
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Introduction: Octreotide; a synthetic analogue of Somatostatin; has been used successfully in palliative patients with excess gastrointestinal secretions. A number of respiratory patients experience cough with excess sputum production. We postulated that octreotide may reduce sputum volume and therefore improve symptoms. Method 8 Patients were initiated on 50mcg octreotide injections. Patients were assessed monthly for efficacy including symptom scores and spirometry. Patients were fitted with a...
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