Yishu Liu
Third Military Medical University
Mural cellH&E stainEndocrinologySurgerySympathetic trunkSympathetic nervous systemVascular endothelial growth factorEvans BlueDiabetic footCD31SympathectomyWound healingAngiogenesisSacrococcygeal RegionSkin Physiological PhenomenaAnesthesiaLumbarMedicineStainingPharmacology
7Publications
3H-index
20Citations
Publications 9
Newest
#1Zhifang Zheng (Southern Medical University)H-Index: 3
#2Yishu Liu (Third Military Medical University)H-Index: 3
Last. Biao Cheng (Third Military Medical University)H-Index: 5
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AbstractDiabetic foot ulcers (DFUs) are a threat to human health and can lead to amputation and even death. Recently neurotensin (NT), an inflammatory modulator in wound healing, was found to be beneficial for diabetic wound healing. As we demonstrated previously, polylactide–polyglycolide (PLGA) and cellulose nanocrystals (CNCs) (PLGA/CNC) nanofiber membranes show good cytocompatibility and facilitate fibroblast adhesion, spreading and proliferation. PLGA/CNC nanofiber membranes are novel mater...
10 CitationsSource
#1Zhifang Zheng (Southern Medical University)H-Index: 3
#2Yishu Liu (Third Military Medical University)H-Index: 3
Last. Biao ChengH-Index: 5
view all 6 authors...
BACKGROUND: The effect of lumbar sympathectomy for the treatment of lower limb ischemia remains a matter of controversy. METHODS: Sprague-Dawley rats were subjected to lumbar sympathectomy, after which Evans blue dye was injected into the hind plantar skin. Extravasation of dye was measured and compared with rats undergoing sham operation. Hind plantar skin was processed for HE staining, immunohistochemistry, and Western blot. RESULTS: In sympathectomized rats, blue stained areas in hind plantar...
4 CitationsSource
#1Zhifang Zheng (Southern Medical University)H-Index: 3
#2Yu Wan (Southern Medical University)H-Index: 1
Last. Biao ChengH-Index: 5
view all 7 authors...
Previous studies focused on the effects of sympathetic denervation with 6-hydroxydopamine (6-OHDA) on nondiabetic wounds, but the effects of 6-OHDA on diabetic wounds have not been previously reported. In this study, treated mice received intraperitoneal 6-OHDA, and control mice received intraperitoneal injections of normal saline. Full-thickness wounds were established on the backs of mice. The wounds were sectioned (four mice per group) for analysis at 2, 5, 7, 10, 14, 17, and 21 days after in...
2 CitationsSource
#1Zhifang Zheng (Southern Medical University)H-Index: 3
#2Yishu Liu (Third Military Medical University)H-Index: 3
Last. Biao Cheng (Third Military Medical University)H-Index: 5
view all 6 authors...
Local sympathetic denervation by surgical sympathectomy is used in the treatment of lower limb ulcers and ischemia, but the restoration of cutaneous sympathetic nerve functions is less clear. This study aims to explore the recovery of cutaneous sympathetic functions after bilateral L2-4 sympathectomy. The skin temperature of the left feet, using a point monitoring thermometer, increased intraoperatively after sympathectomy. The cytoplasm of sympathetic neurons contained tyrosine hydroxylase and ...
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#1Zhifang Zheng (Southern Medical University)H-Index: 3
#2Yishu LiuH-Index: 3
Last. Biao Cheng (Southern Medical University)H-Index: 1
view all 5 authors...
Diabetic foot ulcers (DFUs) are a constant threat to diabetic patients and can lead to amputations and even death. Intralesional administration of propranolol in diabetic wounds has not been reported previously. This study aimed to investigate the efficacy of propranolol cream in diabetic wounds. Fifty-six spontaneously diabetic mice were divided into the propranolol group and the control group. After preparing full-thickness wounds on the back of the mice, 1% propranolol cream was topically app...
7 CitationsSource
#1Zhifang ZhengH-Index: 3
#2Yishu LiuH-Index: 3
Last. Biao ChengH-Index: 1
view all 3 authors...
Sympathetic denervation is associated with many diseases. Most cutaneous external monitoring indicators are non-invasive and used widely in clinical medicine. The external monitoring indicators of sympathetic denervation are reviewed to facilitate the clinical diagnosis of sympathetic diseases and the results of sympathectomy. Useful indicators of sympathetic denervation include sweating, warm skin, increased blood flow, Electrodermal Activity (EDA), pain response, skin integrity, and skin wrink...
1 Citations
#1Zhifang ZhengH-Index: 3
#2Yu WanH-Index: 1
Last. Biao ChengH-Index: 5
view all 7 authors...
BACKGROUND: Sympathetic denervation and impaired angiogenesis cause skin diseases. However, the relationship between the sympathetic nervous system and vascular cell turnover in normal skin remains unclear. OBJECTIVE: To determine the effects of sympathetic denervation on vascular cell turnover in normal skin. METHODS: Rats underwent bilateral L2-4 sympathetic trunk resection (sympathectomy group) or sham operation (control). Hindfoot plantar skin was analyzed 2 weeks and 3 months postoperativel...
1 CitationsSource
#1Zhifang ZhengH-Index: 3
#2Yishu LiuH-Index: 3
Last. Biao ChengH-Index: 1
view all 5 authors...
Pressure Ulcers (PUs) severely impair patient quality of life and account for a high percentage of annual healthcare costs. Lumbar sympathectomy has previously been used for the treatment of chronic leg ulcers. It is still unclear, however, whether lumbar sympathectomy accelerates wound healing in sacrococcygeal skin, a high-risk area for PUs in mostly bedridden patients. Thirty-six Sprague Dawley rats were randomly assigned to the lumbar sympathectomised group, the sham-operated group, and the ...
#1Yishu Liu (Third Military Medical University)H-Index: 3
#2Zhifang ZhengH-Index: 3
Last. Biao Cheng (Southern Medical University)H-Index: 1
view all 3 authors...
To investigate the effect of hydrochloric propranolol cream and its possible mechanism on wound healing in diabetic mice.Eighteen 8-week-old BKS.Cg-Dock7m+/+Leprdb/JNju diabetic mice were randomly divided into control group (n=9) and experimental group (n=9). After full-thickness dermal wounds (0.6?cm in diameter) was made, wounds were treated with cream containing hydrochloric propranolol (experimental group) or not containing hydrochloric propranolol (control group) at 2, 5, 7, 10, 14, and 17 ...
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