Vittorio Emanuele Bianchi
Wake Forest University
AnabolismCardiac function curveInternal medicineEndocrinologyProinflammatory cytokineCardiologyAdipose tissueMortality rateAdipokineInflammationInsulin resistanceAndrogenSleep apneaHeart failureMediterranean dietDiseaseInsulinBody mass indexMetabolic syndromeOverweightAmyotrophic lateral sclerosisAndrogen TherapyIn patientPhysiologyAlzheimer's diseaseObesityWeight lossMalnutritionMedicineEjection fraction
17Publications
8H-index
349Citations
Publications 17
Newest
#2Elena Bresciani (University of Milano-Bicocca)H-Index: 11
Last. Antonio Torsello (University of Milano-Bicocca)H-Index: 36
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Androgens in women, as well as in men, are intrinsic to maintenance of (i) reproductive competency, (ii) cardiac health, (iii) appropriate bone remodeling and mass retention, (iii) muscle tone and mass, and (iv) brain function, in part, through their mitigation of neurodegenerative disease effects. In recognition of the pluripotency of endogenous androgens, exogenous androgens, and selected congeners, have been prescribed off-label for several decades to treat low libido and sexual dysfunction i...
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Nutrition is the primary source of energy production for myocardial contractility and to maintaining cardiac efficiency. Although many studies provided evidence of the benefits of nutritional intervention in chronic heart failure patients (CHF), these effects are not still completely understood. We searched in PubMed and Embase articles related to the following keywords: “chronic heart failure” with “diet,” “nutrition,” “insulin resistance,” and “caloric restriction.” Of the 975 retrieved articl...
3 CitationsSource
#2Laura Rizzi (University of Milano-Bicocca)H-Index: 3
Last. Antonio Torsello (University of Milano-Bicocca)H-Index: 36
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Neurodegenerative diseases, including Alzheimer disease (AD), Parkinson disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), and Huntington disease, are characterized by the loss of neurons as well as neuronal function in multiple regions of the central and peripheral nervous systems. Several studies in animal models have shown that androgens have neuroprotective effects in the brain and stimulate axonal regeneration. The presence of neuronal androgen receptors in the peri...
2 CitationsSource
Summary Background and aims Nutrition exerts a determinant role in maintaining cardiac function, regulating insulin and mitochondrial efficiency, that are essential to support energy production for contractility. In patients with heart failure (HF), myocardial tissue efficiency is reduced because of decreased mitochondrial oxidative capacity. In HF conditions, cardiomyocytes shift toward glucose and a reduction in fatty acid utilization. Calorie restriction induces weight loss in obese patients ...
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Abstract The metabolic sources of energy for myocardial contractility include mainly free fatty acids (FFA) for 95%, and in lesser amounts for 5% from glucose and minimal contributions from other substrates such lactate, ketones, and amino acids. However, myocardial efficiency is influenced by metabolic condition, overload, and ischemia. During cardiac stress, cardiomyocytes increase glucose oxidation and reduce FFA oxidation. In patients with ischemic coronary disease and heart failure, the low...
4 CitationsSource
#2Pomares Fredy Herrera (University of Cartagena)H-Index: 1
Last. Rizzi Laura (University of Milano-Bicocca)H-Index: 1
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ABSTRACTNeurodegenerative diseases are characterized by the progressive functional loss of neurons in the brain, causing cognitive impairment and motoneuron disability. Although multifactorial inte...
24 CitationsSource
: Low plasma testosterone (T) levels correlated with metabolic syndrome, cardiovascular diseases, and increased mortality risk. T exerts a significant effect on the regulation of adipose tissue accumulation, and in the glucose and lipids metabolism. Adipocytes are the primary source of the most important adipokines responsible for inflammation and chronic diseases. This review aims to analyze the possible effect of T on the regulation of the proinflammatory cytokines secretion. A systematic lite...
55 CitationsSource
Summary Background Chronic inflammation is a process sustained by the augmentation of circulating cytokines level and C-reactive protein (CRP). Adipocytes and adipose tissue infiltration with inflammatory cells, are an important source of adipokines production, and their expansion due to overnutrition is responsible for increased in inflammation. The reduction of body fat following both controlled diets or gastric surgery can be favorable in the reduction of pro-inflammatory cytokines. Methods A...
39 CitationsSource
The cardiovascular system is particularly sensitive to androgens, but some controversies exist regarding the effect of testosterone on the heart. While among anabolic abusers, cases of sudden cardiac death have been described, recently it was reported that low serum level of testosterone was correlated with increased risk of cardiovascular diseases (CVD) and mortality rate. This review aims to evaluate the effect of testosterone on myocardial tissue function, coronary artery disease (CAD), and d...
14 CitationsSource
: Metabolic syndrome (MetS) is highly correlated with cardiovascular diseases. Although an excess of body fat is a determinant factor for MetS development, a reduced level of testosterone plays a fundamental role in its regulation. Low testosterone level is highly related to insulin resistance, visceral obesity and MetS. We have searched in Pubmed clinical trial with the password: testosterone and insulin resistance, and testosterone and MetS. We found 19 studies on the correlation between testo...
25 CitationsSource