Ziyi Li
Jilin University
GeneInternal medicineEndocrinologyCellular differentiationGene expressionMolecular biologyAndrologyChemistryDNA methylationEmbryoSomatic cell nuclear transferHomeobox protein NANOGOocyteSOX2BlastocystMethylationEpigeneticsHistoneReprogrammingBiologyEmbryogenesisCell biology
76Publications
14H-index
552Citations
Publications 80
Newest
#1Yanhui Zhai (JLU: Jilin University)H-Index: 5
#2Meng Zhang (JLU: Jilin University)H-Index: 9
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
view all 9 authors...
Pre-implantation embryos undergo genome-wide DNA demethylation, however certain regions, like imprinted loci remain methylated. However, the mechanisms ensuring demethylation resistance by TRIM28 in epigenetic reprogramming remain poorly understood. Here, TRIM28 was knocked down in oocytes, and its effects on porcine somatic cell nuclear transfer (SCNT) embryo development was examined. Our results showed that SCNT embryos constructed from Trim28 knockdown oocytes had significantly lower cleavage...
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#1Huan Cai (JLU: Jilin University)H-Index: 1
#1Huan Cai (JLU: Jilin University)H-Index: 4
Last. Xueming Zhang (JLU: Jilin University)H-Index: 9
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Germplasm cryopreservation and expansion of gonocytes/prospermatogonia or spermatogonial stem cells (SSCs) are important; however, it's difficult in cattle. Since inhibitors of Mek1/2 and Gsk3β (2i) can enhance pluripotency maintenance, effects of 2i-based medium on the cultivation of bovine prospermatogonia from the cryopreserved tissues were examined. The testicular tissues of newborn bulls were well cryopreserved. High mRNA levels of prospermatogonium/SSC markers (PLZF, GFRα-1) and pluripoten...
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#1Rong Huang (JLU: Jilin University)H-Index: 2
#2Liyan Sui (JLU: Jilin University)H-Index: 2
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
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HDAC11, the sole member of HDAC class IV family, plays vital roles in activating mitosis and apoptosis of tumor cells, but its functions in meiosis are rarely investigated. In the present study, the effect of HDAC11 on meiosis during porcine oocytes maturation was fully studied. The results showed that HDAC11 inhibition by its specific inhibitor JB-3-22 dramatically decreased the porcine oocyte maturation rate by disturbing spindle organization and chromosomes alignment without affecting the cyt...
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#2Hao Sun (CAS: Chinese Academy of Sciences)H-Index: 54
Last. Qi ZhouH-Index: 63
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Low birth efficiency and developmental abnormalities in embryos derived using round spermatid injection (ROSI) limit the clinical application of this method. Further, the underlying molecular mechanisms remain elusive and warrant further in-depth study. In this study, the embryonic day (E) 11.5 mouse fetuses and corresponding placentas derived upon using ROSI, intracytoplasmic sperm injection (ICSI), and natural in vivo fertilized (control) embryos were collected. Transcriptome and DNA methylati...
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#1Daoyu Zhang (JLU: Jilin University)H-Index: 1
#2Xinglan An (JLU: Jilin University)H-Index: 10
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
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Breast cancer is one of the most prevalent and reoccurring cancer types that leads to death in women. Triple-negative breast cancer (TNBC) is difficult to treat due to the lack of therapeutic targets. Many studies have focused on identifying drugs for use as alternative treatments for breast cancer. Thioguanine (6-TG) exerts antitumor effects in cancer. Increasing evidence has demonstrated that ceRNAs are involved in cancer processes. However, the mechanism by which 6-TG regulates lncRNA-miRNA-m...
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#1Meng Zhang (JLU: Jilin University)H-Index: 9
#2Yanhui Zhai (JLU: Jilin University)H-Index: 5
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
view all 5 authors...
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#1Hao Li (JLU: Jilin University)H-Index: 1
#2Xinglan An (JLU: Jilin University)H-Index: 10
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
view all 5 authors...
Previous research has proven that 6-thioguanine (6-TG) inhibits the growth of MCF-7 breast cancer cells. Accumulating evidence indicates that long non-coding (lnc)RNAs are involved in the development of various cancer types as competitive endogenous (ce)RNA molecules. The present study was conducted to investigate the regulatory mechanism underlying the function of lncRNAs as ceRNA molecules in MCF-7 cells and to identify more effective prognostic biomarkers for breast cancer treatment. The expr...
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#1Meng ZhangH-Index: 9
#2Sheng ZhangH-Index: 9
Last. Ziyi LiH-Index: 14
view all 8 authors...
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#1Daoyu Zhang (JLU: Jilin University)H-Index: 1
#2Xinglan An (JLU: Jilin University)H-Index: 10
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
view all 10 authors...
Triple-negative breast cancer (TNBC) is notoriously difficult to treat due to the lack of biological targets and poor sensitivity to conventional therapies. Chemotherapy is the main clinical therapy, but the effective screening strategy for chemotherapy drugs is poorly investigated. Drug repositioning has been the center of attention in recent years attracting numerous studies. Here, we firstly found multiple common features between leukemia and TNBC by analyzing the global transcriptome profile...
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#1Jian Zhang (JLU: Jilin University)H-Index: 165
#2Linlin Hao (JLU: Jilin University)H-Index: 1
Last. Bo Tang (JLU: Jilin University)H-Index: 13
view all 11 authors...
Somatic cell nuclear transfer (SCNT) has been successfully used for cloning in a variety of mammalian species. However, SCNT reprogramming efficiency is relatively low, in part due to incomplete DNA methylation reprogramming of donor cell nuclei. We previously showed that ten-eleven translocation 3 (TET3) is responsible for active DNA demethylation during preimplantation embryonic development in bovines. In this study, we constructed TET3-overexpressing cell lines in vitro and observed that the ...
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