Chunjie Zhao
Shenyang Pharmaceutical University
Therapeutic effectPharmacokineticsIonChemical compositionPesticideMass spectrometryFourier transform ion cyclotron resonanceCarbohydrate metabolismHigh-performance liquid chromatographyBioavailabilityChemistryDecoctionMetabolic pathwaySupercritical fluid extractionRadixIn vivoMetabolomicsHeptachlorFormic acidAcetonitrileMitomycin CUrineTriterpeneAnthraquinonesHepatic fibrosisChemical constituentsChromatographyLipid metabolismLiquid chromatography–mass spectrometryProtein precipitationPharmacology
20Publications
6H-index
80Citations
Publications 20
Newest
#1Ruixue LiuH-Index: 1
#2Yu ChenH-Index: 1
Last. Miao WangH-Index: 9
view all 6 authors...
: The established analytical method for determining the concentration of dantrolene sodium (Da) in rat tissues by HPLC/MS/MS technique was successfully applied to tissue distribution studies of Da in rats. Tissue homogenate samples were pretreated by protein precipitation with pre-cooled methanol. Chromatographic separation was achieved on an Acquity HPLC column (Kromat Universil XB-C18 , 2.1 × 150 mm, 3 μm). Mass spectrometry was conducted with an electrospray ionization interface in negative i...
1 CitationsSource
#1Hongmei Yang (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
Last. Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
view all 6 authors...
Mitomycin C (MMC), naturally synthesized by Streptomyces caespitosus, is a potent antineoplastic antibiotic for the treatment of various solid tumors. However, the defects of conventional MMC injections have greatly limited its clinical application due to its toxic side effects and non-specific interactions. To solve this problem, the PEG2k-Fmoc-Ibuprofen (PEG-FIbu) micellar nanocarrier was synthesized and the MMC-loaded micelles (PEG-FIbu/MMC) were prepared by thin film hydration method and cha...
1 CitationsSource
#1Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
#2Juan Jiang (SPU: Shenyang Pharmaceutical University)H-Index: 2
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
view all 7 authors...
: Posaconazole (PCZ) is a triazole antifungal agent with an extended spectrum of antifungal activity. It is approved for the prophylaxis of invasive fungal infections in patients with neutropenia or in hematopoietic stem cell transplant recipients undergoing high-dose immunosuppressive therapy for graft-vs-host disease, and for the treatment of fungal infections. However, its pharmacological effects are severely limited owing to its poor solubility and low bioavailability. In order to solve thes...
2 CitationsSource
#1Zhibo Guan (SPU: Shenyang Pharmaceutical University)H-Index: 2
#2Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
view all 6 authors...
Abstract Sijunzi decoction, a renowned Chinese prescription has long been utilized to treat gastrointestinal problems. In the context of this research work, the use of Ultra high performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry was made to separate and characterize the components of Sijunzi decoction. The performance of Liquid chromatography was carried out on a C8 column (150 mm × 2.1 mm, 1.8 μm); moreover, the mobile phase were consist...
10 CitationsSource
#1Zhibo Guan (SPU: Shenyang Pharmaceutical University)H-Index: 2
#2Juan Wu (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
view all 8 authors...
Abstract Ethnopharmacological relevance Sijunzi decoction (SJZD) is a well known traditional Chinese prescription used for the treatment of gastrointestinal disorders and immunity enhancement. It has been found to indeed improve life quality of chemotherapy patients and extensive used in clinical conbined with chemotherapeutics for the treatment of cancer. Aim of the study The aim of this study was to investigate the preventive effect of the immunotoxicity of SJZD on mitomycin C (MMC) and the me...
13 CitationsSource
#1Yinan Wang (SPU: Shenyang Pharmaceutical University)H-Index: 7
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
view all 7 authors...
Cortex Fraxini is an important traditional Chinese herbal medicine used for the treatment of gout and hyperuricemia. An efficient and rapid ultra-performance liquid chromatography mass spectrometry method was developed and validated for simultaneous quantitation of six coumarins (aesculin, fraxin, aesculetin, fraxetin, sopoletin and 7-hydroxycoumarin) in normal and hyperuricemic rats plasma after oral administration of Cortex Fraxini. The method could successfully be applied for pharmacokinetics...
6 CitationsSource
#1Jian Wu (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Bo Hong (Qiqihar Medical University)H-Index: 1
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
view all 6 authors...
Based upon the regulations stipulated by the State Food and Drug Administration of China, only the processed, detoxified tubers and roots of Aconitum are allowed to be administered orally, used in clinical decoctions and adopted as raw materials for pharmaceutical manufacturing, so the processing principle of preparation of Radix Aconiti is important for ensuring the Radix Aconiti praeparata quality. A simple approach was described for HPLC-Q-TOF-MS screening and identification of many of the ac...
10 CitationsSource
#1Bo Hong (SPU: Shenyang Pharmaceutical University)H-Index: 2
#2Jin GaoH-Index: 1
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
view all 4 authors...
A new acridone alkaloid, named 9-hydroxynoracronycine (1), together with four known compounds, including coumarins, lignan, and indole alkaloid, was isolated and identified from the roots and rhizomes of Rauvolfia verticillata. The structure of the new compound was determined by spectroscopic means (UV, IR, MS, and NMR). The acridone alkaloid and coumarins were identified as new constituents of Rauvolfia genus. The cytotoxic activities of the new compound were tested against human breast cancer ...
7 CitationsSource
#1Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
#2Guiming HaoH-Index: 2
Last. Yingjie Chen (SPU: Shenyang Pharmaceutical University)H-Index: 2
view all 5 authors...
A method involving depuration of 12 organochlorine pesticides (OCPs) from Radix codonopsis was developed using supercritical fluid extraction (SFE). The pesticides investigated in the study included α-, β-, γ- and δ-benzene hexachloride, PCNB (pentachloro-nitrobenzene), PCA (pentachloroaniline), HEPT (heptachlor), MPCPS (methyl-pentachlorophenyl sulfide), pp′-DDE [1,1-dichloro-2, 2-bis(p-chlorophenyl) ethylene], op′-DDT [1,1,1-trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane], pp′-DDD [1,1-...
15 CitationsSource
#1Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
#2Guiming Hao (SPU: Shenyang Pharmaceutical University)H-Index: 2
Last. Yingjie Chen (SPU: Shenyang Pharmaceutical University)H-Index: 2
view all 4 authors...
A method involving the simultaneous extraction and separation of 12 organochlorine pesticides (OCPs) from Angelicae sinensis was developed using supercritical fluid extraction (SFE). The pesticides in the study were α-, β-, γ- and δ-benzene hexachloride, PCNB (pentachloro- nitrobenzene), PCA (pentachloroaniline), HEPT (heptachlor), MPCPS (methyl-pentachlorophenyl sulfide), pp′-DDE [1,1-dichloro-2,2-bis (p-chlorophenyl) ethylene], op′-DDT [1,1,1,-trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl) et...
11 CitationsSource