Shabnam Malik
University of Texas at Austin
Clonogenic assayCancerChemistryApoptosisCyclin D1In vitroIn vivoTumor microenvironmentOrmeloxifeneGLUT1Pancreatic tumorPancaMetastasisProstate cancerPancreatic cancerCucurbitacinMMP2Cucurbitacin DCell cycleCancer researchCarcinogenesisCell growthMedicineBiologyCancer cell
23Publications
8H-index
179Citations
Publications 14
Newest
#1Andrew E. Massey (NIH: National Institutes of Health)H-Index: 5
#1Andrew E. Massey (NIH: National Institutes of Health)
Last. Bilal B. Hafeez (University of Texas at Austin)H-Index: 3
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Exosomes are nanoscale vesicles generated by cells for intercellular communication. Due to their composition, significant research has been conducted to transform these particles into specific delivery systems for various disease states. In this review, we discuss the common isolation and loading methods of exosomes, some of the major roles of exosomes in the tumor microenvironment, as well as discuss recent applications of exosomes as drug delivery vessels and the resulting clinical implication...
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#1Mohammed Sikander (University of Texas at Austin)H-Index: 7
#1Mohammed Sikander (University of Texas at Austin)
Last. Meena Jaggi (University of Texas at Austin)H-Index: 1
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COVID-19 is known as one of the deadliest pandemics of the century. The rapid spread of this deadly virus at incredible speed has stunned the planet and poses a challenge to global scientific and medical communities. Patients with COVID-19 are at an increased risk of co-morbidities associated with liver dysfunction and injury. Moreover, hepatotoxicity induced by antiviral therapy is gaining importance and is an area of great concern. Currently, alternatives therapies are being sought to mitigate...
1 CitationsSource
#1Vivek K. Kashyap (UTHSC: University of Tennessee Health Science Center)H-Index: 8
#1Vivek Kumar Kashyap (UTHSC: University of Tennessee Health Science Center)H-Index: 1
Last. Subhash C. Chauhan (UTHSC: University of Tennessee Health Science Center)H-Index: 5
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Abstract In this study, we investigated the therapeutic efficacy of VERU-111 in vitro and in vivo model systems of cervical cancer. VERU-111 treatment inhibited cell proliferation and, clonogenic potential, induce accumulation of p53 and down regulated the expression of HPV E6/E7 expression in cervical cancer cells. In addition, VERU-111 treatment also decreased the expression of phosphorylation of Jak2 (TyR1007/1008) and STAT3 at Tyr705 and Ser727. VERU-111 treatment arrested cell cycle in the ...
3 CitationsSource
#1Mohammed Sikander (UTHSC: University of Tennessee Health Science Center)H-Index: 7
#2Shabnam Malik (UTHSC: University of Tennessee Health Science Center)H-Index: 8
Last. Subhash C. ChauhanH-Index: 49
view all 11 authors...
Pancreatic cancer (PanCa) is one of the leading causes of death from cancer in the United States. The current standard treatment for pancreatic cancer is gemcitabine, but its success is poor due to the emergence of drug resistance. Natural products have been widely investigated as potential candidates in cancer therapies, and cucurbitacin D (Cuc D) has shown excellent anticancer properties in various models. However, there is no report on the therapeutic effect of Cuc D in PanCa. In the present ...
7 CitationsSource
#1Mohammed SikanderH-Index: 7
#2Shabnam MalikH-Index: 8
Last. Meena Jaggi (UT: University of Tennessee)H-Index: 36
view all 13 authors...
Background: Cervical cancer (CxC) is a leading cause of mortality and morbidity among women worldwide. Current chemotherapeutic agents for CxC have shown systemic toxicity in CxC patients. Ormeloxifene (ORM) is a non-toxic and non-steroidal drug with well-defined pharmacokinetic and pharmacodynamic properties in humans. Studies have shown its anti-cancer potential in various pre-clinical mouse models. Here, we have synthesized and characterized a novel analogue of ormeloxifene, Bromo-ormeloxifen...
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#1Mohammed Sikander (UT: University of Tennessee)H-Index: 7
#2Shabnam Malik (UT: University of Tennessee)H-Index: 8
Last. Subhash C. ChauhanH-Index: 49
view all 12 authors...
Prostate cancer (PrCa) metastasis is the major cause of mortality and morbidity among men. Metastatic PrCa cells are typically adopted for aberrant glucose metabolism. Thus, chemophores that reprogram altered glucose metabolic machinery in cancer cells can be useful agent for the repression of PrCa metastasis. Herein, we report that cucurbitacin D (Cuc D) effectively inhibits glucose uptake and lactate production in metastatic PrCa cells via modulating glucose metabolism. This metabolic shift by...
13 CitationsSource
#1Mohammed Sikander (UT: University of Tennessee)H-Index: 7
#2Shabnam Malik (UT: University of Tennessee)H-Index: 8
Last. Subhash C. Chauhan (UT: University of Tennessee)H-Index: 49
view all 7 authors...
Background: Docetaxel (DTX) is an FDA approved drug for the treatment of advanced prostate cancer (PrCa). However, chemo-resistance and toxicity limits its use in clinic. Accumulating evidence suggests that activation of cancer stem cells (CSCs) is one of the mechanisms leading to developing chemo-resistance Therefore, identification of new pharmacophores that can target CSCs may improve the therapeutic efficacy of docetaxel for the treatment of advanced PrCa. Cucurbitacin D is one of the potent...
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#1Sheema Khan (UT: University of Tennessee)H-Index: 4
#2Kyle Doxtater (UT: University of Tennessee)
Last. Meena Jaggi (UT: University of Tennessee)H-Index: 36
view all 10 authors...
Objective: Pancreatic cancer (PanCa) is the third leading cause of cancer-related deaths in the U.S. MUC13, mucin, is aberrantly expressed in PanCa and its overexpression leads to tumorigenic and metastatic behavior of cancer cells. Herein, we investigate the role of MUC13 in tumor microenvironment (TME) that favors PanCa progression/metastasis and drug resistance. Methods: MUC13 expressing (Panc-1) and knockdown PanCa cells (HPAF-II) and pancreatic stromal cells (PSCs), derived from freshly col...
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#1Bilal B. HafeezH-Index: 2
#1Bilal B. HafeezH-Index: 3
Last. Subhash C. ChauhanH-Index: 5
view all 11 authors...
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#1Vivek K. Kashyap (UTHSC: University of Tennessee Health Science Center)H-Index: 8
#2Bilal Bin Hafeez (UTHSC: University of Tennessee Health Science Center)H-Index: 29
Last. Subhash C. Chauhan (UTHSC: University of Tennessee Health Science Center)H-Index: 49
view all 15 authors...
Objective: Cervical cancer is one of the most common and deadly cancers among women worldwide and is associated with persistent Human Papillomavirus (HPV) infection. Human papilloma virus (HPV) expressing E6 and E7 oncoproteins involved in carcinogenesis through their interactions with the p53 and pRB pathways, respectively. Therefore, non-toxic agents that have potential to inhibit the expression of E6 and E7 oncoproteins and their regulated oncogenic signaling pathways could be used in the man...
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