Lori B. Chibnik
Harvard University
GeneGenome-wide association studyInternal medicineSingle-nucleotide polymorphismOdds ratioProspective cohort studyDNA methylationCohort studyImmunologyRheumatoid arthritisDiseaseDementiaPopulationCognitive declineAlzheimer's diseaseGeneticsBioinformaticsMedicineCohortBiology
Publications 166
#1Sun Jae Jung (Yonsei University)H-Index: 11
#2Ga Bin Lee (Yonsei University)H-Index: 2
Last. Hyeon Chang Kim (Yonsei University)H-Index: 44
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To examine the association between psychological resilience and cognitive function and investigate the role of acute inflammation as an effect modifier. Total 7535 people from the Cardiovascular and Metabolic Disease Etiology Research Center (CMERC), aged ≥ 50 years and residing in areas near Seoul, South Korea, were included in this cross-sectional analysis. Stressful life events in the past 6 months were gauged by the Life Experience Survey, and current depression symptoms were analyzed with t...
#1Sun Jae Jung (Harvard University)H-Index: 11
#2Ye Jin Jeon (Yonsei University)H-Index: 1
Last. Karestan C. Koenen (Harvard University)H-Index: 105
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OBJECTIVE: We aimed to investigate the mental health impact of COVID-19 on a demographically well-characterized population cohort by gender and previous depression status. METHODS: Among people who participated in a community cohort study between 2013 and 2018 with previous depression measurement, a total of 1928 people without quarantine experience (680 men and 1249 women) were included after responding to an online survey in March 2020. In the 2020 survey, people were queried about daily needs...
#1Mei Cq Houser (Harvard University)H-Index: 1
#2Yuliia Turchyna (Harvard University)H-Index: 1
Last. Masato Maesako (Harvard University)H-Index: 13
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Presenilin (PS)/γ-secretase is an aspartyl protease that processes a wide range of transmembrane proteins such as the amyloid precursor protein (APP) and Notch1, playing essential roles in normal biological events and diseases. However, whether there is a substrate preference for PS/γ-secretase processing in cells is not fully understood. Structural studies of PS/γ-secretase enfolding a fragment of APP or Notch1 showed that the two substrates engage the protease in broadly similar ways, suggesti...
#1Elizabeth G. Atkinson (Harvard University)H-Index: 8
#2Shareefa Dalvie (UCT: University of Cape Town)H-Index: 16
Last. NeuroGAP-Psychosis Study Team (Broad Institute)H-Index: 1
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African populations are the most diverse in the world yet are sorely underrepresented in medical genetics research. Here, we examine the structure of African populations using genetic and comprehensive multigenerational ethnolinguistic data from the Neuropsychiatric Genetics of African Populations-Psychosis study (NeuroGAP-Psychosis) consisting of 900 individuals from Ethiopia, Kenya, South Africa, and Uganda. We find that self-reported language classifications meaningfully tag underlying geneti...
#1Alicia R. Martin (Harvard University)H-Index: 29
#2Elizabeth G. Atkinson (Harvard University)H-Index: 8
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Summary Genetic studies in underrepresented populations identify disproportionate numbers of novel associations. However, most genetic studies use genotyping arrays and sequenced reference panels that best capture variation most common in European ancestry populations. To compare data generation strategies best suited for underrepresented populations, we sequenced the whole genomes of 91 individuals to high coverage as part of the Neuropsychiatric Genetics of African Population-Psychosis (NeuroG...
2 CitationsSource
#1Christopher D. Stephen (Harvard University)H-Index: 12
#2David L. Perez (Harvard University)H-Index: 20
Last. Nutan Sharma (Harvard University)H-Index: 27
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OBJECTIVE Functional dystonia (FD) is a disabling and diagnostically challenging functional movement disorder (FMD). We sought to identify historical predictors of FD vs. other primary dystonias (ODs) and develop a practical prediction algorithm to guide neurologists. METHODS 1475 consecutive new patient medical records were reviewed at an adult/pediatric tertiary-referral dystonia clinic from 2005 to 2017. Ninety-nine met criteria for clinically established FD (85 adults and 14 pediatric), pair...
#1Rebecca B Lawn (Harvard University)H-Index: 5
#1Rebecca B Lawn (Harvard University)
Last. Laura D. Kubzansky (Harvard University)H-Index: 81
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Background: Posttraumatic stress disorder (PTSD) is associated with higher risk of certain chronic diseases, including ovarian cancer, but underlying mechanisms remain unclear. While prior work has linked menopausal hormone therapy (MHT) use with elevated ovarian cancer risk, little research considers PTSD to likelihood of MHT use. We examined whether PTSD was prospectively associated with greater likelihood of initiating MHT use over 26 years. Methods: Using data from the Nurses9 Health Study I...
#1Simon Dujardin (Harvard University)H-Index: 19
#2Caitlin Commins (Harvard University)H-Index: 10
Last. Bradley T. Hyman (Harvard University)H-Index: 184
view all 27 authors...
#1Andrew Ratanatharathorn (Columbia University)H-Index: 15
#2Karestan C. Koenen (Harvard University)H-Index: 105
Last. Andrea L. Roberts (Harvard University)H-Index: 36
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People who experience childhood abuse are at increased risk of mental illness. Twin studies suggest that inherited genetic risk for mental illness may account for some of these associations. Yet, the hypothesis that individuals who have experienced childhood abuse may carry genetic loading for mental illness has never been tested with genetic data. Using polygenic risk scores for six psychiatric disorders-attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar di...
#1Ellis PatrickH-Index: 15
#2Marta Olah (Columbia University)H-Index: 1
Last. Philip L. De JagerH-Index: 107
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Microglial dysfunction has been proposed as one of the many cellular mechanisms that can contribute to the development of Alzheimer's disease (AD). Here, using a transcriptional network map of the human frontal cortex, we identify five modules of co-expressed genes related to microglia and assess their role in the neuropathologic features of AD in 540 subjects from two cohort studies of brain aging. Two of these transcriptional programs-modules 113 and 114-relate to the accumulation of β-amyloid...
2 CitationsSource