Ying Jiang
Boston University
Biological neural networkBiophysicsBiomedical engineeringUltrasoundNeuromodulation (medicine)Photoacoustic effectRaman scatteringMembrane potentialElectrophysiologyChemistryMaterials scienceOptical fiberIn vitroAcoustic waveImage resolutionEnergy conversion efficiencyIn vivoStimulationNeuronSlice preparationBrain stimulationCoupling (electronics)Common emitterOptoelectronicsLaserPhotoacoustic imaging in biomedicineModulationTransducerSonoporationPulse (signal processing)
17Publications
4H-index
60Citations
Publications 17
Newest
#1Hyeon Jeong Lee (ZJU: Zhejiang University)H-Index: 11
#2Ying Jiang (BU: Boston University)H-Index: 4
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 84
view all 3 authors...
Abstract Offering high temporal resolution, voltage imaging is an important and essential technique in neuroscience. Among different optical imaging approaches, the label-free approach remains attractive due to its unique value coming from free of exogenous chromophores. The intrinsic voltage-indicating signals arising from membrane deformation, membrane spectral change, phase shift, light scattering, and membrane hydration haven been reported. First demonstrated 70 years ago, label-free optical...
Source
#1Linli ShiH-Index: 1
#2Ying JiangH-Index: 4
Last. Chen YangH-Index: 74
view all 7 authors...
Focused ultrasound has attracted great attention in minimally invasive therapy, gene delivery, brain stimulation, etc. Frequency below 1 MHz has been identified preferable for high-efficacy drug delivery, gene transfection and neurostimulation due to minimized tissue heating and cell fragmentation. However, the poor spatial resolution of several millimeters and the large device diameter of ~25 mm of current sub-MHz ultrasound technology severely hinders its further applications for effective, pr...
#1Ying JiangH-Index: 4
#2Lu Lan (BU: Boston University)H-Index: 14
Last. Ji-Xin ChengH-Index: 84
view all 7 authors...
Ultrasound has been recently explored as a new modality for neural modulation. However, one of the challenges in ultrasound neural modulation is that delivery of transcranial ultrasound would inevitably go through the skull, and eventually reach the cochlear through bone transduction. Moreover, the presence of skull will compromise ultrasound focus, resulting in poor spatial resolution. Here, we developed a miniaturized Fiber-Optoacoustic Converter (FOC), which has a diameter of 600 μm, and can ...
Source
#1Ying Jiang (BU: Boston University)H-Index: 4
#2Lu Lan (BU: Boston University)H-Index: 14
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 84
view all 7 authors...
Generation of ultrasound using the optoacoustic effect has received increasing attention in the field of imaging and translational medicine. However, none of the current optoacoustic converters has been used for neural modulation. Here, we developed a miniaturized Fiber-Optoacoustic Converter (FOC), which has a diameter of 600 μm, and can convert nano-second laser pulses into acoustic waves through the optoacoustic effect. The ball shaped FOC is composed of one ZnO /epoxy based diffusion layer a...
Source
#1Yimin Huang (BU: Boston University)H-Index: 10
#2Ying Jiang (BU: Boston University)H-Index: 4
Last. Chen Yang (BU: Boston University)H-Index: 74
view all 9 authors...
After injuries, axonal regeneration over long distance is challenging due to lack of orientation guidance. Biocompatible scaffolds have been used to mimic the native organization of axons to guide and facilitate axonal regeneration. Those scaffolds are of great importance in achieving functional connections of the nervous system. We have developed a nanoladder scaffold to guide directional outgrowth and facilitate regeneration of axons. The nanoladders, composed of micron-scale stripes and nanos...
Source
#1Hyeon Jeong Lee (Purdue University)H-Index: 11
#2Delong Zhang (Purdue University)H-Index: 22
Last. Ji-Xin Cheng (Purdue University)H-Index: 84
view all 11 authors...
Detecting membrane potentials is critical for understanding how neuronal networks process information. We report a vibrational spectroscopic signature of neuronal membrane potentials identified through hyperspectral stimulated Raman scattering (SRS) imaging of patched primary neurons. High-speed SRS imaging allowed direct visualization of puff-induced depolarization of multiple neurons in mouse brain slices, confirmed by simultaneous calcium imaging. The observed signature, partially dependent o...
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#1Xiaoli Guo (SJTU: Shanghai Jiao Tong University)H-Index: 8
#2Yongzhi He (SJTU: Shanghai Jiao Tong University)H-Index: 1
Last. Shanbao Tong (SJTU: Shanghai Jiao Tong University)H-Index: 28
view all 7 authors...
The intact crossed pathway via which the contralesional hemisphere responds to the ipsilesional somatosensory input has shown to be affected by unilateral stroke. The aim of this study was to investigate the plasticity of the intact crossed pathway in response to different intensities of stimulation in a rodent photothrombotic stroke model. Using optical intrinsic signal imaging, an overall increase of the contralesional cortical response was observed in the acute phase (≤48 hours) after stroke....
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