Ying Jiang
Boston University
Biological neural networkBiophysicsBiomedical engineeringUltrasoundNeuromodulation (medicine)Photoacoustic effectRaman scatteringMembrane potentialElectrophysiologyChemistryMaterials scienceOptical fiberIn vitroAcoustic waveImage resolutionEnergy conversion efficiencyIn vivoStimulationNeuronSlice preparationBrain stimulationCoupling (electronics)Common emitterOptoelectronicsLaserPhotoacoustic imaging in biomedicineModulationTransducerSonoporationPulse (signal processing)
17Publications
4H-index
60Citations
Publications 16
Newest
#1Linli Shi (BU: Boston University)H-Index: 1
#2Ying Jiang (BU: Boston University)H-Index: 4
Last. Chen Yang (BU: Boston University)H-Index: 69
view all 9 authors...
Neuromodulation at high spatial resolution poses great significance in advancing fundamental knowledge in the field of neuroscience and offering novel clinical treatments. Here, we developed a tapered fiber optoacoustic emitter (TFOE) generating an ultrasound field with a high spatial precision of 39.6 µm, enabling optoacoustic activation of single neurons or subcellular structures, such as axons and dendrites. Temporally, a single acoustic pulse of sub-microsecond converted by the TFOE from a s...
Source
#1Linli Shi (BU: Boston University)H-Index: 1
#2Ying Jiang (BU: Boston University)H-Index: 4
Last. Chen Yang (BU: Boston University)H-Index: 69
view all 4 authors...
Towards non-genetic, precise neural stimulation, we develop a photoacoustic neural stimulation technology. It employs a fiber-based optoacoustic process, in which pulsed light is delivered through an optical fiber into an absorbing layer coated at the tip, resulting in transient heating and generating a localized acoustic wave. We report photoacoustic stimulation in vitro and in vivo through a lab-built fiber based optoacoustic emitter (FOE). Single neuron optoacoustic neural modulation is achie...
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#1Yimin Huang (BU: Boston University)H-Index: 10
#2Ying Jiang (BU: Boston University)H-Index: 4
Last. Chen Yang (BU: Boston University)H-Index: 69
view all 6 authors...
Toward non-genetic non-invasive neural modulation with a submillimeter precision, we report the development and application of photoacoustic nanotransducers (PAN) to neural stimulation in cultured primary neurons and in live brain. Our PAN, based on synthesized semiconducting polymer nanoparticles, efficiently generate localized ultrasound by a photoacoustic process upon absorption of nanosecond pulsed light in the NIR-II window. We showed that PAN binding on the neuron membrane through non-spec...
Source
#1Minghua Zhuge (ZJU: Zhejiang University)H-Index: 5
#2Kai-Chih Huang (BU: Boston University)H-Index: 9
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 11 authors...
High-sensitivity chemical imaging offers a window to decipher the molecular orchestra inside a living system. Based on vibrational fingerprint signatures, coherent Raman scattering microscopy provides a label-free approach to map biomolecules and drug molecules inside a cell. Yet, by near-infrared (NIR) pulse excitation, the sensitivity is limited to millimolar concentration for endogenous biomolecules. Here, the imaging sensitivity of stimulated Raman scattering (SRS) is significantly boosted f...
3 CitationsSource
#1Ying Jiang (BU: Boston University)H-Index: 4
#2Yimin Huang (BU: Boston University)H-Index: 10
Last. Lu Lan (BU: Boston University)H-Index: 12
view all 15 authors...
Summary Neuromodulation is an invaluable approach for the study of neural circuits and clinical treatment of neurological diseases. Here, we report semiconducting polymer nanoparticles based photoacoustic nanotransducers (PANs) for neural stimulation in vitro and in vivo. Our PANs strongly absorb the nanosecond pulsed laser in the near-infrared second window (NIR-II) and generate localized acoustic waves. PANs are shown to be surface modified and selectively bind onto neurons. PAN-mediated activ...
1 CitationsSource
#1Linli Shi (BU: Boston University)H-Index: 1
#2Ying Jiang (BU: Boston University)H-Index: 4
Last. Chen Yang (BU: Boston University)H-Index: 69
view all 9 authors...
As an emerging technology, transcranial focused ultrasound has been demonstrated to successfully evoke motor responses in mice, rabbits, and sensory/motor responses in humans. Yet, the spatial resolution of ultrasound does not allow for high-precision stimulation. Here, we developed a tapered fiber optoacoustic emitter (TFOE) for optoacoustic stimulation of neurons with an unprecedented spatial resolution of 20 microns, enabling selective activation of single neurons or subcellular structures, s...
#1Linli Shi (BU: Boston University)H-Index: 1
#2Ying Jiang (BU: Boston University)H-Index: 4
Last. Chen Yang (BU: Boston University)H-Index: 69
view all 7 authors...
Abstract Focused ultrasound has attracted great attention in minimally invasive therapeutic and mechanism studies. Frequency below 1 MHz is identified preferable for high-efficiency bio-modulation. However, the poor spatial confinement of several millimeters and large device diameter of ∼25 mm of typical sub-MHz ultrasound technology suffered from the diffraction limit, severely hindering its further applications. To address it, a fiber-based optoacoustic emitter (FOE) is developed, serving as a...
4 CitationsSource
#1Lu Lan (BU: Boston University)H-Index: 12
#2Yueming Li (BU: Boston University)H-Index: 1
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 6 authors...
Microwaves, which have a ∼10-cm wavelength, can penetrate deeper into tissue than photons, heralding exciting deep tissue applications such as modulation or imaging via the thermoacoustic effect. Thermoacoustic conversion efficiency is however very low, even with an exogenous contrast agent. We break this low-conversion limit, using a split ring resonator to effectively collect and confine the microwaves into a submillimeter hot spot for ultrasound emission and achieve a conversion efficiency ov...
2 CitationsSource
#1Yimin Huang (BU: Boston University)H-Index: 10
#2Ying Jiang (BU: Boston University)H-Index: 4
Last. Chen Yang (BU: Boston University)H-Index: 69
view all 13 authors...
Neuromodulation is an invaluable approach for study of neural circuits and clinical treatment of neurological diseases. Here, we report semiconducting polymer nanoparticles based photoacoustic nanotransducers (PANs) for neural stimulation. Our PANs strongly absorb light in the near-infrared second window and generate localized acoustic waves. PANs can also be surface-modified to selectively bind onto neurons. PAN-mediated activation of primary neurons in vitro is achieved with ten 3-nanosecond l...
Source
#1Ying Jiang (BU: Boston University)H-Index: 4
#2Hyeon Jeong LeeH-Index: 10
Last. Ji-Xin ChengH-Index: 83
view all 8 authors...
Low-intensity ultrasound is an emerging modality for neuromodulation. Yet, transcranial neuromodulation using low-frequency piezo-based transducers offers poor spatial confinement of excitation volume, often bigger than a few millimeters in diameter. In addition, the bulky size limits their implementation in a wearable setting and prevents integration with other experimental modalities. Here, we report spatially confined optoacoustic neural stimulation through a miniaturized Fiber-Optoacoustic C...
15 CitationsSource