Alfonso Buil
Mental Health Services
GeneGenome-wide association studyInternal medicinePhenotypeSNPGenetic linkageGene expressionSingle-nucleotide polymorphismHeritabilityRegulation of gene expressionExpression quantitative trait lociAlleleGenetic associationGenetic analysisPopulationGeneticsBioinformaticsCandidate geneMedicineQuantitative trait locusLocus (genetics)BiologyGenetic architecture
127Publications
34H-index
5,973Citations
Publications 119
Newest
#1Xueping Liu (Centre for Mental Health)H-Index: 6
#1Xueping Liu (Centre for Mental Health)H-Index: 1
Last. Michael E. Benros (Centre for Mental Health)H-Index: 32
view all 15 authors...
1 CitationsSource
#1Sergio Picart-Armada (UPC: Polytechnic University of Catalonia)H-Index: 5
#2Wesley K. ThompsonH-Index: 68
Last. Alexandre Perera-Lluna (UPC: Polytechnic University of Catalonia)H-Index: 12
view all 4 authors...
MOTIVATION Network diffusion and label propagation are fundamental tools in computational biology, with applications like gene-disease association, protein function prediction and module discovery. More recently, several publications have introduced a permutation analysis after the propagation process, due to concerns that network topology can bias diffusion scores. This opens the question of the statistical properties and the presence of bias of such diffusion processes in each of its applicati...
1 CitationsSource
#2Katrine FalkenbergH-Index: 4
Last. Thomas Hansen (Novo Nordisk Foundation)H-Index: 78
view all 9 authors...
Migraine attacks are delimited, allowing investigation of changes during and outside attack. Gene expression fluctuates according to environmental and endogenous events and therefore, we hypothesized that changes in RNA expression during and outside a spontaneous migraine attack exist which are specific to migraine. Twenty-seven migraine patients were assessed during a spontaneous migraine attack, including headache characteristics and treatment effect. Blood samples were taken during attack, tw...
1 CitationsSource
#1Lene Aarøe (AU: Aarhus University)H-Index: 13
#2Vivek AppaduraiH-Index: 11
Last. Michael Bang Petersen (AU: Aarhus University)H-Index: 33
view all 14 authors...
Although the genetic influence on voter turnout is substantial (typically 40–50%), the underlying mechanisms remain unclear. Across the social sciences, research suggests that ‘resources for politics’ (as indexed notably by educational attainment and intelligence test performance) constitute a central cluster of factors that predict electoral participation. Educational attainment and intelligence test performance are heritable. This suggests that the genotypes that enhance these phenotypes could...
1 CitationsSource
#1Xueping Liu (Centre for Mental Health)H-Index: 6
#2Ron Nudel (CMHS: Mental Health Services)H-Index: 9
Last. Michael E. Benros (Centre for Mental Health)H-Index: 32
view all 15 authors...
Abstract Background Previous studies have indicated the bidirectionality between autoimmune and mental disorders. However, genetic studies underpinning the co-occurrence of the two disorders have been lacking. In this study, we examined the potential genetic contribution to the association between autoimmune and mental disorders and investigated the genetic basis of overall autoimmune disease. Methods We used diagnostic information from patients with seven autoimmune diseases and six mental diso...
6 CitationsSource
Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are highly heritable neurodevelopmental disorders that frequently co-occur. Both rare and common genetic variants are important for ASD and ADHD risk but their combined contribution to clinical heterogeneity is unclear. In a sample of 39 ASD and/or ADHD families we estimated the overall variance explained by known rare copy number variants (CNVs) and polygenic risk score (PRS) from common variants to be 10% in com...
2 CitationsSource
#1Jonas Bybjerg-Grauholm (SSI: Statens Serum Institut)H-Index: 30
#2Carsten Bøcker Pedersen (Lundbeck)H-Index: 69
Last. Preben Bo Mortensen (AU: Aarhus University)H-Index: 133
view all 17 authors...
Abstract The Lundbeck Foundation Integrative Psychiatric Research (iPSYCH) consortium has almost doubled its Danish population-based Case–Cohort sample (iPSYCH2012). The newly updated cohort, named iPSYCH2015, expands the study base with 56,233 samples, to a combined total of 141,265 samples. The cohort is nested within the Danish population born between 1981 and 2008 and is a Case-Cohort design including 50,615 population controls. We added more cases to the existing phenotypes identified with,...
4 CitationsSource
#1Yunpeng WangH-Index: 34
#2Ron Nudel (Lundbeck)H-Index: 9
Last. Thomas Werge (UCPH: University of Copenhagen)H-Index: 77
view all 15 authors...
Circulating inflammatory markers are essential to human health and disease, and they are often dysregulated or malfunctioning in cancers as well as in cardiovascular, metabolic, immunologic and neuropsychiatric disorders. However, the genetic contribution to the physiological variation of levels of circulating inflammatory markers is largely unknown. Here we report the results of a genome-wide genetic study of blood concentration of ten cytokines, including the hitherto unexplored calcium-bindin...
1 CitationsSource
#1Line SkotteH-Index: 14
#2João FadistaH-Index: 26
Last. Bjarke FeenstraH-Index: 41
view all 39 authors...
Febrile seizures represent the most common type of pathological brain activity in young children and are influenced by genetic, environmental, and developmental factors. While usually benign, in a minority of cases, febrile seizures precede later development of epilepsy. Here, we conducted a genome-wide association study of febrile seizures with 7,635 cases and 93,966 controls identifying and replicating seven new loci, all with P < 5 x 10-10. Variants at two loci were functionally related to al...
1 CitationsSource
#1João Fadista (SSI: Statens Serum Institut)H-Index: 26
Last. Bjarke FeenstraH-Index: 41
view all 18 authors...
ABSTRACT Importance Spermine oxidase (SMOX) catalyzes the oxidation of spermine to spermidine. Observational studies have reported SMOX as a source of induced reactive oxygen species associated with cancer, implying that inhibition of SMOX could be a target for chemoprevention. Objective To test the causality of SMOX levels with cancer risk using a Mendelian randomization analysis. Design, Setting, and Participants We performed a GWAS of spermidine/spermine ratio, from blood of 534 infants, to i...
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